TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3758c/proV:

update plot	correlation	link to info on gene
Rv1087/PE_PGRS21	(cc=0.4767)	info on Rv1087/PE_PGRS21
Rv1044/-	(cc=0.4633)	info on Rv1044/-
Rv2841c/nusA	(cc=0.4231)	info on Rv2841c/nusA
Rv2873/mpt83	(cc=0.4213)	info on Rv2873/mpt83
Rv1948c/-	(cc=0.409)	info on Rv1948c/-
Rv2850c/-	(cc=0.4029)	info on Rv2850c/-
Rv3417c/groEL1	(cc=0.3974)	info on Rv3417c/groEL1
Rv1091/PE_PGRS22	(cc=0.3933)	info on Rv1091/PE_PGRS22
Rv1676/-	(cc=0.3922)	info on Rv1676/-
Rv1597/-	(cc=0.386)	info on Rv1597/-

Correlation of Rv3758c/proV with Rv3417c/groEL1

Normalized LFCs for Rv3758c/proV:
(description and provenance of datasets)

	Rv3758c/proV	Rv3417c/groEL1
Fe_supp_jason_reseq	0.096	1.528
low_pH_jason_reseq	-0.393	0.0
NO_jason_reseq	0.312	0.16
B6_jason_reseq	0.084	0.133
MHCII_jason_reseq	-0.766	0.631
Isoniazid02	0.023	0.585
Rifampicin4	-0.376	0.523
Ethambutol3	0.117	0.946
Meropenem3	0.188	0.839
Vancomycin16	1.263	0.936
Rv2680_day32	0.617	0.632
H37Rv_KO_MarP	0.711	0.432
hypoxia_3wks	0.056	1.156
hypoxia_6wks	0.198	-0.867
glycerol	0.671	1.24
cholesterol	0.178	0.68
AJ	0.108	1.76
Bibs02	0.544	0.183
Bibs02c	0.677	1.325
BL6	0.634	-0.091
BL6a	-0.023	1.291
BXD01	0.241	0.582
BXD010	0.502	0.762
BXD011	-0.178	0.383
BXD03	-0.364	0.604
BXD04	-0.867	0.465
BXD05	0.047	-0.314
BXD06	-0.065	0.627
BXD07	0.048	-0.1
BXD08	0.542	0.292
BXD09	-0.235	0.916
CAST	-0.14	-0.082
CCcont	0.391	1.662
DS01	0.216	2.091
DS02	0.444	2.113
DS04	0.76	1.228
DS0c	0.919	1.534
GP01	1.102	0.188
GP02	-0.083	0.479
GP0c	0.541	0.17
NOD	-0.605	1.38
NZO	-0.631	1.706
PWK	0.283	0.831
H37Rv_KO_CtpC	-0.019	-1.294
H37Rv_KO_CtpD	1.574	2.216
H37Rv_KO_Rv1272	0.553	1.29
H37Rv_KO_SugABC	0.111	1.777
H37Rv_KO_MbtN	0.942	0.196
Trans05	0.228	-1.041
macrophage_unactivated	-0.098	-0.328
IL1	-0.967	-3.275
Rapamycin	-0.344	-1.307
Tcell	-1.062	-2.74
GMCSF	-0.082	-1.125
IFNab	-0.596	0.828
IFNg	-0.433	-1.021
IFNg_GMCSF1	-0.198	-0.804
Rv1432_day32	-0.679	-0.391
Rv1565c_day32	-0.122	1.655
secA2_input	0.26	0.283
delta_Rv3594	0.407	0.45
delta_Rv3717	0.079	0.058
delta_Rv3811	0.271	0.409
delta_Rv0954	-0.152	1.085
PonA1	0.055	-0.027
EccD1_KO	0.069	0.0
EspI_KO	-0.933	-0.528
PE35_KO	0.061	0.295
PPE68_KO	-0.205	0.323
glycerol2	0.212	-0.262
lignocerate	0.133	-1.173
oleate	0.14	0.155
phosphatidylcholine	-0.015	-1.183
acetate	0.268	-0.871
glucAc	-0.024	-1.156
Rv0950ko	0.199	-0.145
Rv1096ko	0.576	0.093
Rv3684ko	0.046	-0.052
delta_otsA_trehalose	0.803	0.861