TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3758c/proV:

update plot	correlation	link to info on gene
Rv1087/PE_PGRS21	(cc=0.4767)	info on Rv1087/PE_PGRS21
Rv1044/-	(cc=0.4633)	info on Rv1044/-
Rv2841c/nusA	(cc=0.4231)	info on Rv2841c/nusA
Rv2873/mpt83	(cc=0.4213)	info on Rv2873/mpt83
Rv1948c/-	(cc=0.409)	info on Rv1948c/-
Rv2850c/-	(cc=0.4029)	info on Rv2850c/-
Rv3417c/groEL1	(cc=0.3974)	info on Rv3417c/groEL1
Rv1091/PE_PGRS22	(cc=0.3933)	info on Rv1091/PE_PGRS22
Rv1676/-	(cc=0.3922)	info on Rv1676/-
Rv1597/-	(cc=0.386)	info on Rv1597/-

Correlation of Rv3758c/proV with Rv1597/-

Normalized LFCs for Rv3758c/proV:
(description and provenance of datasets)

	Rv3758c/proV	Rv1597/-
Fe_supp_jason_reseq	0.096	0.224
low_pH_jason_reseq	-0.393	0.736
NO_jason_reseq	0.312	0.394
B6_jason_reseq	0.084	0.115
MHCII_jason_reseq	-0.766	0.094
Isoniazid02	0.023	0.589
Rifampicin4	-0.376	0.081
Ethambutol3	0.117	-0.178
Meropenem3	0.188	0.737
Vancomycin16	1.263	0.305
Rv2680_day32	0.617	0.675
H37Rv_KO_MarP	0.711	0.817
hypoxia_3wks	0.056	0.12
hypoxia_6wks	0.198	0.14
glycerol	0.671	0.805
cholesterol	0.178	0.036
AJ	0.108	-0.328
Bibs02	0.544	1.02
Bibs02c	0.677	-0.08
BL6	0.634	1.072
BL6a	-0.023	-0.491
BXD01	0.241	0.11
BXD010	0.502	0.315
BXD011	-0.178	-0.041
BXD03	-0.364	0.146
BXD04	-0.867	0.297
BXD05	0.047	0.05
BXD06	-0.065	0.174
BXD07	0.048	0.165
BXD08	0.542	0.391
BXD09	-0.235	0.324
CAST	-0.14	-0.41
CCcont	0.391	0.467
DS01	0.216	0.626
DS02	0.444	0.258
DS04	0.76	0.887
DS0c	0.919	0.738
GP01	1.102	0.336
GP02	-0.083	0.621
GP0c	0.541	0.551
NOD	-0.605	-1.009
NZO	-0.631	-0.156
PWK	0.283	-0.566
H37Rv_KO_CtpC	-0.019	0.366
H37Rv_KO_CtpD	1.574	0.472
H37Rv_KO_Rv1272	0.553	1.026
H37Rv_KO_SugABC	0.111	-0.327
H37Rv_KO_MbtN	0.942	0.323
Trans05	0.228	0.36
macrophage_unactivated	-0.098	-0.704
IL1	-0.967	-0.273
Rapamycin	-0.344	-0.341
Tcell	-1.062	-0.218
GMCSF	-0.082	-0.309
IFNab	-0.596	-0.614
IFNg	-0.433	-0.329
IFNg_GMCSF1	-0.198	-0.408
Rv1432_day32	-0.679	0.708
Rv1565c_day32	-0.122	0.655
secA2_input	0.26	-0.985
delta_Rv3594	0.407	-0.096
delta_Rv3717	0.079	0.403
delta_Rv3811	0.271	0.381
delta_Rv0954	-0.152	0.441
PonA1	0.055	0.631
EccD1_KO	0.069	0.467
EspI_KO	-0.933	0.1
PE35_KO	0.061	0.298
PPE68_KO	-0.205	-0.698
glycerol2	0.212	0.434
lignocerate	0.133	0.654
oleate	0.14	-0.149
phosphatidylcholine	-0.015	0.723
acetate	0.268	0.46
glucAc	-0.024	0.612
Rv0950ko	0.199	0.19
Rv1096ko	0.576	-0.283
Rv3684ko	0.046	-0.884
delta_otsA_trehalose	0.803	0.585