TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2994/-:

update plot	correlation	link to info on gene
Rv1318c/-	(cc=0.5048)	info on Rv1318c/-
Rv2701c/suhB	(cc=0.4907)	info on Rv2701c/suhB
Rv0036c/-	(cc=0.4744)	info on Rv0036c/-
Rv2771c/-	(cc=0.471)	info on Rv2771c/-
Rv3714c/-	(cc=0.4678)	info on Rv3714c/-
Rv3444c/esxT	(cc=0.4664)	info on Rv3444c/esxT
Rv3733c/-	(cc=0.4664)	info on Rv3733c/-
Rv2319c/-	(cc=0.4652)	info on Rv2319c/-
Rv0372c/-	(cc=0.464)	info on Rv0372c/-
Rv0395/-	(cc=0.4579)	info on Rv0395/-

Correlation of Rv2994/- with Rv3714c/-

Normalized LFCs for Rv2994/-:
(description and provenance of datasets)

	Rv2994/-	Rv3714c/-
Fe_supp_jason_reseq	-0.358	-0.398
low_pH_jason_reseq	-0.865	-0.363
NO_jason_reseq	-0.074	0.011
B6_jason_reseq	0.503	0.719
MHCII_jason_reseq	0.585	1.035
Isoniazid02	0.192	0.778
Rifampicin4	0.72	-0.011
Ethambutol3	0.413	0.55
Meropenem3	0.207	-0.108
Vancomycin16	0.531	1.387
Rv2680_day32	-0.56	0.488
H37Rv_KO_MarP	0.099	0.169
hypoxia_3wks	0.335	0.49
hypoxia_6wks	0.695	1.184
glycerol	-0.278	-1.508
cholesterol	-0.106	-0.909
AJ	0.131	0.202
Bibs02	-0.012	-0.147
Bibs02c	0.45	0.108
BL6	0.603	-0.168
BL6a	0.363	-0.013
BXD01	-0.321	0.43
BXD010	-0.158	0.139
BXD011	0.293	0.21
BXD03	-0.026	0.323
BXD04	-0.42	0.597
BXD05	0.398	-0.14
BXD06	0.009	0.267
BXD07	0.144	0.08
BXD08	0.222	0.297
BXD09	-0.009	0.279
CAST	0.143	0.607
CCcont	-0.494	-0.643
DS01	0.419	0.433
DS02	-0.284	0.651
DS04	-0.142	1.023
DS0c	0.5	0.638
GP01	0.516	-0.144
GP02	0.412	0.641
GP0c	-0.141	-0.46
NOD	0.208	1.111
NZO	-0.16	0.526
PWK	0.182	0.367
H37Rv_KO_CtpC	-0.064	-0.288
H37Rv_KO_CtpD	-0.251	0.055
H37Rv_KO_Rv1272	-0.968	-1.053
H37Rv_KO_SugABC	1.032	-0.819
H37Rv_KO_MbtN	-1.404	-0.526
Trans05	-0.209	-0.625
macrophage_unactivated	-0.445	0.095
IL1	-0.047	0.0
Rapamycin	-0.457	-0.19
Tcell	-0.782	0.935
GMCSF	0.821	0.079
IFNab	-0.221	-0.333
IFNg	-0.353	-0.029
IFNg_GMCSF1	-0.415	-0.072
Rv1432_day32	1.036	1.288
Rv1565c_day32	0.294	0.158
secA2_input	0.614	0.769
delta_Rv3594	0.167	-0.971
delta_Rv3717	0.118	-0.799
delta_Rv3811	-0.123	-1.387
delta_Rv0954	-0.021	-1.0
PonA1	-0.575	-0.336
EccD1_KO	-0.109	-0.697
EspI_KO	0.046	-0.371
PE35_KO	-0.61	-0.446
PPE68_KO	-0.106	-0.403
glycerol2	-0.626	-0.661
lignocerate	-0.772	-0.621
oleate	-0.4	-0.793
phosphatidylcholine	-0.437	-0.793
acetate	-0.874	-1.614
glucAc	-1.191	-0.741
Rv0950ko	0.048	0.724
Rv1096ko	0.832	0.552
Rv3684ko	0.452	0.196
delta_otsA_trehalose	1.026	0.411