TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0970/-:

update plot	correlation	link to info on gene
Rv0301/vapC2	(cc=0.4223)	info on Rv0301/vapC2
Rv3683/-	(cc=0.4098)	info on Rv3683/-
Rv3912/-	(cc=0.4087)	info on Rv3912/-
Rv2734/-	(cc=0.4037)	info on Rv2734/-
Rv1164/narI	(cc=0.3962)	info on Rv1164/narI
Rv1435c/-	(cc=0.3839)	info on Rv1435c/-
Rv2568c/-	(cc=0.3709)	info on Rv2568c/-
Rv2873/mpt83	(cc=0.3615)	info on Rv2873/mpt83
Rv2529/-	(cc=0.3591)	info on Rv2529/-
Rv1759c/wag22	(cc=0.3566)	info on Rv1759c/wag22

Correlation of Rv0970/- with Rv1435c/-

Normalized LFCs for Rv0970/-:
(description and provenance of datasets)

	Rv0970/-	Rv1435c/-
Fe_supp_jason_reseq	0.017	-1.814
low_pH_jason_reseq	-0.462	-1.447
NO_jason_reseq	0.407	0.389
B6_jason_reseq	-0.723	-1.602
MHCII_jason_reseq	-0.935	-0.561
Isoniazid02	-0.383	-0.33
Rifampicin4	-0.712	-4.151
Ethambutol3	0.738	-0.098
Meropenem3	1.487	0.392
Vancomycin16	-0.663	-4.067
Rv2680_day32	0.402	0.354
H37Rv_KO_MarP	0.237	-0.46
hypoxia_3wks	0.291	-2.293
hypoxia_6wks	-0.938	-2.266
glycerol	-0.519	0.796
cholesterol	0.585	0.752
AJ	0.437	0.941
Bibs02	0.332	0.91
Bibs02c	-0.094	0.524
BL6	-0.22	0.716
BL6a	0.409	0.851
BXD01	-0.373	0.068
BXD010	0.555	0.045
BXD011	0.784	-0.247
BXD03	-0.03	0.137
BXD04	-0.391	0.105
BXD05	0.15	-0.381
BXD06	0.421	-0.176
BXD07	-0.256	-0.183
BXD08	0.306	-0.687
BXD09	-0.471	0.57
CAST	0.18	0.792
CCcont	-0.289	0.743
DS01	-0.457	2.007
DS02	-0.2	2.043
DS04	-0.711	0.833
DS0c	1.053	1.328
GP01	1.114	1.244
GP02	0.568	2.058
GP0c	0.337	0.233
NOD	-0.687	-0.636
NZO	-0.266	1.241
PWK	0.308	-0.144
H37Rv_KO_CtpC	0.255	0.735
H37Rv_KO_CtpD	-0.057	-0.167
H37Rv_KO_Rv1272	0.366	1.66
H37Rv_KO_SugABC	0.969	0.587
H37Rv_KO_MbtN	0.066	0.018
Trans05	1.066	0.787
macrophage_unactivated	-0.06	0.328
IL1	0.027	0.967
Rapamycin	-0.206	0.559
Tcell	0.15	0.0
GMCSF	-0.074	0.378
IFNab	0.193	0.493
IFNg	0.468	0.684
IFNg_GMCSF1	0.525	0.914
Rv1432_day32	-0.966	-0.299
Rv1565c_day32	-1.21	-0.967
secA2_input	0.182	0.186
delta_Rv3594	-0.265	-0.381
delta_Rv3717	-0.345	-0.044
delta_Rv3811	-0.369	-0.474
delta_Rv0954	0.121	-0.123
PonA1	-0.271	-0.352
EccD1_KO	0.089	-0.858
EspI_KO	-0.385	-0.183
PE35_KO	-0.277	-0.073
PPE68_KO	-0.211	0.384
glycerol2	-0.527	0.706
lignocerate	0.106	1.846
oleate	0.043	-0.669
phosphatidylcholine	-0.13	1.013
acetate	0.098	1.662
glucAc	1.209	1.034
Rv0950ko	0.76	1.315
Rv1096ko	0.461	-0.449
Rv3684ko	0.904	-0.278
delta_otsA_trehalose	0.0	0.116