TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0944/-:

update plot	correlation	link to info on gene
Rv2833c/ugpB	(cc=0.4935)	info on Rv2833c/ugpB
Rv3528c/-	(cc=0.4688)	info on Rv3528c/-
Rv3576/lppH	(cc=0.4545)	info on Rv3576/lppH
Rv0480c/-	(cc=0.4318)	info on Rv0480c/-
Rv0927c/-	(cc=0.3999)	info on Rv0927c/-
Rv1473A/-	(cc=0.3975)	info on Rv1473A/-
Rv2161c/-	(cc=0.3939)	info on Rv2161c/-
Rv0055/rpsR1	(cc=0.3927)	info on Rv0055/rpsR1
Rv2668/-	(cc=0.3777)	info on Rv2668/-
Rv3123/-	(cc=0.3772)	info on Rv3123/-

Correlation of Rv0944/- with Rv3576/lppH

Normalized LFCs for Rv0944/-:
(description and provenance of datasets)

	Rv0944/-	Rv3576/lppH
Fe_supp_jason_reseq	-0.706	-0.753
low_pH_jason_reseq	-0.811	0.35
NO_jason_reseq	0.475	0.029
B6_jason_reseq	-0.843	-0.579
MHCII_jason_reseq	1.757	0.829
Isoniazid02	0.474	-0.544
Rifampicin4	1.11	-0.319
Ethambutol3	0.564	-0.775
Meropenem3	0.779	-0.581
Vancomycin16	1.231	-0.342
Rv2680_day32	-0.351	-0.152
H37Rv_KO_MarP	0.368	-0.037
hypoxia_3wks	-0.73	-0.419
hypoxia_6wks	0.445	-0.129
glycerol	1.185	0.149
cholesterol	0.465	0.164
AJ	1.081	0.19
Bibs02	0.387	-0.23
Bibs02c	0.483	0.682
BL6	1.849	-0.245
BL6a	1.253	0.354
BXD01	1.82	0.075
BXD010	0.101	-0.137
BXD011	0.398	0.114
BXD03	1.526	0.622
BXD04	1.187	0.101
BXD05	-0.337	0.604
BXD06	0.967	0.546
BXD07	0.686	0.316
BXD08	1.104	0.312
BXD09	0.814	0.148
CAST	-0.511	0.077
CCcont	1.548	0.309
DS01	0.082	0.0
DS02	0.66	-0.173
DS04	0.689	-0.703
DS0c	0.31	0.539
GP01	0.099	0.527
GP02	0.223	-0.43
GP0c	-1.839	-0.534
NOD	-0.192	0.254
NZO	-0.787	0.225
PWK	-0.297	-0.085
H37Rv_KO_CtpC	1.567	0.146
H37Rv_KO_CtpD	-1.485	-1.868
H37Rv_KO_Rv1272	1.079	1.39
H37Rv_KO_SugABC	0.718	1.149
H37Rv_KO_MbtN	-1.136	0.052
Trans05	1.133	0.873
macrophage_unactivated	0.978	0.669
IL1	0.119	0.0
Rapamycin	0.092	0.061
Tcell	1.193	-0.065
GMCSF	0.333	0.053
IFNab	-0.593	0.692
IFNg	0.238	-0.334
IFNg_GMCSF1	-0.955	-1.131
Rv1432_day32	-1.027	-0.087
Rv1565c_day32	-1.164	-0.802
secA2_input	0.119	0.357
delta_Rv3594	0.347	-0.049
delta_Rv3717	-0.995	-1.354
delta_Rv3811	-0.665	-0.654
delta_Rv0954	0.43	-0.478
PonA1	-0.675	-0.321
EccD1_KO	-0.73	-1.276
EspI_KO	0.781	-0.739
PE35_KO	0.995	-0.376
PPE68_KO	0.214	-0.598
glycerol2	-0.02	0.018
lignocerate	0.701	0.075
oleate	-0.601	0.052
phosphatidylcholine	0.525	0.472
acetate	0.121	-0.151
glucAc	0.547	-0.067
Rv0950ko	0.458	0.633
Rv1096ko	0.875	0.142
Rv3684ko	1.431	0.724
delta_otsA_trehalose	-1.777	-0.15