TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0944/-:

update plot	correlation	link to info on gene
Rv2833c/ugpB	(cc=0.4935)	info on Rv2833c/ugpB
Rv3528c/-	(cc=0.4688)	info on Rv3528c/-
Rv3576/lppH	(cc=0.4545)	info on Rv3576/lppH
Rv0480c/-	(cc=0.4318)	info on Rv0480c/-
Rv0927c/-	(cc=0.3999)	info on Rv0927c/-
Rv1473A/-	(cc=0.3975)	info on Rv1473A/-
Rv2161c/-	(cc=0.3939)	info on Rv2161c/-
Rv0055/rpsR1	(cc=0.3927)	info on Rv0055/rpsR1
Rv2668/-	(cc=0.3777)	info on Rv2668/-
Rv3123/-	(cc=0.3772)	info on Rv3123/-

Correlation of Rv0944/- with Rv3123/-

Normalized LFCs for Rv0944/-:
(description and provenance of datasets)

	Rv0944/-	Rv3123/-
Fe_supp_jason_reseq	-0.706	0.284
low_pH_jason_reseq	-0.811	-0.109
NO_jason_reseq	0.475	-0.15
B6_jason_reseq	-0.843	-0.259
MHCII_jason_reseq	1.757	-0.627
Isoniazid02	0.474	0.333
Rifampicin4	1.11	1.132
Ethambutol3	0.564	0.17
Meropenem3	0.779	4.053
Vancomycin16	1.231	0.732
Rv2680_day32	-0.351	1.147
H37Rv_KO_MarP	0.368	-0.219
hypoxia_3wks	-0.73	-0.829
hypoxia_6wks	0.445	-0.353
glycerol	1.185	1.181
cholesterol	0.465	-0.312
AJ	1.081	-0.013
Bibs02	0.387	0.011
Bibs02c	0.483	-2.029
BL6	1.849	0.095
BL6a	1.253	0.383
BXD01	1.82	0.583
BXD010	0.101	0.559
BXD011	0.398	0.984
BXD03	1.526	0.489
BXD04	1.187	0.803
BXD05	-0.337	-0.641
BXD06	0.967	1.313
BXD07	0.686	1.024
BXD08	1.104	0.801
BXD09	0.814	0.768
CAST	-0.511	-0.749
CCcont	1.548	0.686
DS01	0.082	-0.163
DS02	0.66	0.214
DS04	0.689	1.696
DS0c	0.31	0.431
GP01	0.099	-0.529
GP02	0.223	-0.77
GP0c	-1.839	-0.792
NOD	-0.192	0.067
NZO	-0.787	-1.049
PWK	-0.297	-0.861
H37Rv_KO_CtpC	1.567	0.727
H37Rv_KO_CtpD	-1.485	-2.311
H37Rv_KO_Rv1272	1.079	-0.144
H37Rv_KO_SugABC	0.718	0.37
H37Rv_KO_MbtN	-1.136	-1.375
Trans05	1.133	-2.431
macrophage_unactivated	0.978	-1.398
IL1	0.119	0.774
Rapamycin	0.092	-1.013
Tcell	1.193	0.521
GMCSF	0.333	0.058
IFNab	-0.593	-0.931
IFNg	0.238	-0.227
IFNg_GMCSF1	-0.955	-0.641
Rv1432_day32	-1.027	-0.434
Rv1565c_day32	-1.164	-0.85
secA2_input	0.119	1.049
delta_Rv3594	0.347	-1.224
delta_Rv3717	-0.995	-1.124
delta_Rv3811	-0.665	-1.697
delta_Rv0954	0.43	-0.293
PonA1	-0.675	-4.213
EccD1_KO	-0.73	0.184
EspI_KO	0.781	0.619
PE35_KO	0.995	-1.143
PPE68_KO	0.214	-0.819
glycerol2	-0.02	0.974
lignocerate	0.701	0.132
oleate	-0.601	0.048
phosphatidylcholine	0.525	0.332
acetate	0.121	-0.454
glucAc	0.547	-0.179
Rv0950ko	0.458	0.772
Rv1096ko	0.875	1.336
Rv3684ko	1.431	0.773
delta_otsA_trehalose	-1.777	1.302