TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0944/-:

update plot	correlation	link to info on gene
Rv2833c/ugpB	(cc=0.4935)	info on Rv2833c/ugpB
Rv3528c/-	(cc=0.4688)	info on Rv3528c/-
Rv3576/lppH	(cc=0.4545)	info on Rv3576/lppH
Rv0480c/-	(cc=0.4318)	info on Rv0480c/-
Rv0927c/-	(cc=0.3999)	info on Rv0927c/-
Rv1473A/-	(cc=0.3975)	info on Rv1473A/-
Rv2161c/-	(cc=0.3939)	info on Rv2161c/-
Rv0055/rpsR1	(cc=0.3927)	info on Rv0055/rpsR1
Rv2668/-	(cc=0.3777)	info on Rv2668/-
Rv3123/-	(cc=0.3772)	info on Rv3123/-

Correlation of Rv0944/- with Rv0927c/-

Normalized LFCs for Rv0944/-:
(description and provenance of datasets)

	Rv0944/-	Rv0927c/-
Fe_supp_jason_reseq	-0.706	0.519
low_pH_jason_reseq	-0.811	0.624
NO_jason_reseq	0.475	2.006
B6_jason_reseq	-0.843	0.264
MHCII_jason_reseq	1.757	0.547
Isoniazid02	0.474	0.505
Rifampicin4	1.11	0.745
Ethambutol3	0.564	-0.022
Meropenem3	0.779	2.216
Vancomycin16	1.231	0.844
Rv2680_day32	-0.351	0.215
H37Rv_KO_MarP	0.368	0.155
hypoxia_3wks	-0.73	0.518
hypoxia_6wks	0.445	1.629
glycerol	1.185	1.246
cholesterol	0.465	0.589
AJ	1.081	0.691
Bibs02	0.387	-0.032
Bibs02c	0.483	1.072
BL6	1.849	0.961
BL6a	1.253	1.135
BXD01	1.82	0.825
BXD010	0.101	0.445
BXD011	0.398	0.897
BXD03	1.526	-0.636
BXD04	1.187	-0.133
BXD05	-0.337	1.703
BXD06	0.967	0.203
BXD07	0.686	0.424
BXD08	1.104	0.446
BXD09	0.814	0.753
CAST	-0.511	0.637
CCcont	1.548	0.663
DS01	0.082	1.102
DS02	0.66	1.232
DS04	0.689	1.715
DS0c	0.31	0.013
GP01	0.099	1.32
GP02	0.223	-0.809
GP0c	-1.839	-0.232
NOD	-0.192	0.026
NZO	-0.787	-0.48
PWK	-0.297	-0.149
H37Rv_KO_CtpC	1.567	0.498
H37Rv_KO_CtpD	-1.485	-0.883
H37Rv_KO_Rv1272	1.079	0.831
H37Rv_KO_SugABC	0.718	1.148
H37Rv_KO_MbtN	-1.136	-1.677
Trans05	1.133	0.12
macrophage_unactivated	0.978	-0.429
IL1	0.119	-0.626
Rapamycin	0.092	-0.196
Tcell	1.193	0.71
GMCSF	0.333	-0.602
IFNab	-0.593	-0.97
IFNg	0.238	-0.144
IFNg_GMCSF1	-0.955	-1.401
Rv1432_day32	-1.027	0.395
Rv1565c_day32	-1.164	0.065
secA2_input	0.119	1.03
delta_Rv3594	0.347	-0.528
delta_Rv3717	-0.995	-1.92
delta_Rv3811	-0.665	-2.898
delta_Rv0954	0.43	-1.118
PonA1	-0.675	-0.607
EccD1_KO	-0.73	1.457
EspI_KO	0.781	1.018
PE35_KO	0.995	2.894
PPE68_KO	0.214	1.923
glycerol2	-0.02	0.824
lignocerate	0.701	0.913
oleate	-0.601	0.544
phosphatidylcholine	0.525	0.919
acetate	0.121	0.108
glucAc	0.547	0.608
Rv0950ko	0.458	-0.971
Rv1096ko	0.875	0.109
Rv3684ko	1.431	-0.337
delta_otsA_trehalose	-1.777	-1.28