TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0069c/sdaA:

update plot	correlation	link to info on gene
Rv0338c/-	(cc=0.7502)	info on Rv0338c/-
Rv0320/-	(cc=0.5463)	info on Rv0320/-
Rv0191/-	(cc=0.4888)	info on Rv0191/-
Rv0373c/-	(cc=0.4568)	info on Rv0373c/-
Rv2189c/-	(cc=0.4479)	info on Rv2189c/-
Rv2715/-	(cc=0.4477)	info on Rv2715/-
Rv3068c/pgmA	(cc=0.4325)	info on Rv3068c/pgmA
Rv2394/ggtB	(cc=0.4302)	info on Rv2394/ggtB
Rv1317c/alkA	(cc=0.4268)	info on Rv1317c/alkA
Rv2073c/-	(cc=0.4251)	info on Rv2073c/-

Correlation of Rv0069c/sdaA with Rv2394/ggtB

Normalized LFCs for Rv0069c/sdaA:
(description and provenance of datasets)

	Rv0069c/sdaA	Rv2394/ggtB
Fe_supp_jason_reseq	0.205	-1.01
low_pH_jason_reseq	-1.367	-0.616
NO_jason_reseq	-1.265	-0.047
B6_jason_reseq	-0.208	-0.383
MHCII_jason_reseq	0.127	-0.607
Isoniazid02	-0.049	0.581
Rifampicin4	-0.233	0.764
Ethambutol3	0.627	2.847
Meropenem3	0.278	1.294
Vancomycin16	0.836	0.565
Rv2680_day32	-0.372	-1.556
H37Rv_KO_MarP	0.217	0.212
hypoxia_3wks	-0.319	0.211
hypoxia_6wks	-0.299	0.111
glycerol	2.392	0.219
cholesterol	6.0	3.29
AJ	0.187	0.356
Bibs02	-0.592	0.34
Bibs02c	0.196	0.053
BL6	0.084	-0.117
BL6a	0.307	0.135
BXD01	-0.154	0.016
BXD010	-0.171	-0.418
BXD011	0.68	0.523
BXD03	-0.631	0.259
BXD04	-0.425	0.454
BXD05	-0.223	0.115
BXD06	-0.038	-0.153
BXD07	-0.207	0.337
BXD08	0.329	0.344
BXD09	0.076	-0.14
CAST	-0.976	0.058
CCcont	0.176	-0.214
DS01	-0.279	0.229
DS02	-0.325	0.121
DS04	-1.036	1.04
DS0c	0.363	0.198
GP01	0.265	0.043
GP02	-0.138	0.164
GP0c	0.639	0.096
NOD	-1.596	0.179
NZO	-1.472	0.496
PWK	0.183	0.323
H37Rv_KO_CtpC	0.213	-0.011
H37Rv_KO_CtpD	-1.75	0.689
H37Rv_KO_Rv1272	-0.72	0.044
H37Rv_KO_SugABC	0.94	0.608
H37Rv_KO_MbtN	1.301	0.599
Trans05	-0.5	0.389
macrophage_unactivated	0.18	0.366
IL1	0.383	0.4
Rapamycin	0.807	-0.387
Tcell	0.42	0.287
GMCSF	-0.264	-0.19
IFNab	1.167	-0.348
IFNg	0.249	-0.166
IFNg_GMCSF1	-0.512	-0.295
Rv1432_day32	0.415	-0.128
Rv1565c_day32	-0.355	-0.019
secA2_input	1.656	-0.26
delta_Rv3594	-0.783	-0.444
delta_Rv3717	-0.2	-0.927
delta_Rv3811	0.299	-0.338
delta_Rv0954	0.399	0.736
PonA1	0.943	0.509
EccD1_KO	0.802	0.763
EspI_KO	-0.645	-0.031
PE35_KO	0.055	0.761
PPE68_KO	0.781	0.682
glycerol2	0.171	0.59
lignocerate	0.183	-0.108
oleate	-0.264	0.713
phosphatidylcholine	-0.067	0.363
acetate	-0.191	-0.404
glucAc	-0.249	-0.315
Rv0950ko	0.582	-0.211
Rv1096ko	0.582	-0.434
Rv3684ko	-0.069	-0.164
delta_otsA_trehalose	0.027	1.096