TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2904c/rplS:

update plot	correlation	link to info on gene
Rv2965c/kdtB	(cc=0.6413)	info on Rv2965c/kdtB
Rv2603c/-	(cc=0.6369)	info on Rv2603c/-
Rv0651/rplJ	(cc=0.6333)	info on Rv0651/rplJ
Rv1636/TB15.3	(cc=0.6254)	info on Rv1636/TB15.3
Rv2135c/-	(cc=0.6217)	info on Rv2135c/-
Rv0736/rslA	(cc=0.5603)	info on Rv0736/rslA
Rv1457c/-	(cc=0.5588)	info on Rv1457c/-
Rv3245c/mtrB	(cc=0.5418)	info on Rv3245c/mtrB
Rv1275/lprC	(cc=0.4768)	info on Rv1275/lprC
Rv2358/smtB	(cc=0.4717)	info on Rv2358/smtB

Correlation of Rv2904c/rplS with Rv1457c/-

Normalized LFCs for Rv2904c/rplS:
(description and provenance of datasets)

	Rv2904c/rplS	Rv1457c/-
Fe_supp_jason_reseq	2.262	0.415
low_pH_jason_reseq	0.0	0.44
NO_jason_reseq	0.69	0.0
B6_jason_reseq	0.0	0.0
MHCII_jason_reseq	0.0	0.0
Isoniazid02	-0.201	0.0
Rifampicin4	0.341	0.374
Ethambutol3	1.44	0.931
Meropenem3	-0.165	0.315
Vancomycin16	0.0	0.0
Rv2680_day32	0.0	-0.131
H37Rv_KO_MarP	-0.586	1.249
hypoxia_3wks	0.0	0.0
hypoxia_6wks	0.0	0.0
glycerol	0.0	0.0
cholesterol	0.0	0.0
AJ	0.0	0.0
Bibs02	0.0	0.0
Bibs02c	0.0	0.0
BL6	0.0	0.0
BL6a	0.0	0.0
BXD01	0.0	0.0
BXD010	0.0	0.0
BXD011	0.0	0.0
BXD03	0.0	0.0
BXD04	0.0	0.0
BXD05	0.0	0.0
BXD06	0.0	0.0
BXD07	0.0	0.0
BXD08	0.0	0.0
BXD09	0.0	0.0
CAST	0.0	0.0
CCcont	1.082	0.0
DS01	0.0	0.0
DS02	0.0	0.0
DS04	0.194	0.37
DS0c	0.0	0.0
GP01	0.0	0.0
GP02	0.0	0.0
GP0c	0.0	0.0
NOD	0.0	0.0
NZO	0.0	0.199
PWK	0.0	0.0
H37Rv_KO_CtpC	0.162	0.0
H37Rv_KO_CtpD	0.127	0.127
H37Rv_KO_Rv1272	0.0	0.0
H37Rv_KO_SugABC	0.099	0.0
H37Rv_KO_MbtN	0.196	0.0
Trans05	0.0	0.0
macrophage_unactivated	0.0	0.0
IL1	-0.409	0.0
Rapamycin	-0.424	0.0
Tcell	-0.45	0.0
GMCSF	0.0	0.0
IFNab	0.0	0.0
IFNg	-0.369	0.0
IFNg_GMCSF1	-0.434	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	3.389	2.821
delta_Rv3594	-0.459	-0.193
delta_Rv3717	-0.243	-0.159
delta_Rv3811	-0.617	0.0
delta_Rv0954	0.22	0.65
PonA1	-0.346	-0.145
EccD1_KO	0.954	-0.793
EspI_KO	0.433	0.0
PE35_KO	-0.767	-0.703
PPE68_KO	1.133	0.0
glycerol2	0.0	0.0
lignocerate	0.0	0.0
oleate	0.0	0.0
phosphatidylcholine	0.0	0.0
acetate	0.0	0.806
glucAc	0.0	0.0
Rv0950ko	0.874	0.0
Rv1096ko	-0.697	0.0
Rv3684ko	0.337	-0.861
delta_otsA_trehalose	0.654	0.564