Rv1457c (-)

Current annotations:
- TBCAP: (community-based annotations - see table at bottom of page)
- TBDB: DrrB family ABC transporter efflux protein
- REFSEQ: unidentified antibiotic-transport integral membrane ABC transporter
- PATRIC: ABC-type multidrug transport system permease component
- TUBERCULIST: Probable unidentified antibiotic-transport integral membrane ABC transporter
- NCBI: Probable unidentified antibiotic-transport integral membrane ABC transporter
- updated information (H37Rv4):
  - gene name: -
  - function:
  - reference:
Type: Essential
Start: 1642537
End: 1643322
Operon:

Trans-membrane region:
Role: II.C.5 - Other membrane proteins
GO terms:
- GO:1900753 - doxorubicin transport (Uniprot)
- GO:0055085 - transmembrane transport (Uniprot)
- GO:0046677 - response to antibiotic (Uniprot)
- GO:0043215 - daunorubicin transport (Uniprot)
- GO:0043190 - ATP-binding cassette (ABC) transporter complex (Uniprot)
- GO:0042891 - antibiotic transport (Uniprot)
- GO:0040007 - growth (Uniprot)
- GO:0016021 - integral component of membrane (Uniprot)
- GO:0016020 - membrane (Uniprot)
Reaction(s) (based on iSM810 metabolic model):
Gene Expression Profile (Transcriptional Responses to Drugs; Boshoff et al, 2004)
Gene Modules extracted from cluster analysis of 249 transcriptomic datasets using ICA
Orthologs among selected mycobacteria
Protein structure:
Search for Homologs in PDB
Top 10 Homologs in PDB (as of Nov 2020): (none with >35% aa id)
Links to additional information on Rv1457c:
- TBDB (updated)
- Phyre2 structure prediction, model: final.casp.pdb (from Mao et al, 2013)
- UniProt
- AlphaFold model
- Vulnerability = -1.406 (from Jeremy Rock's lab)
- KEGG - nucleotide and amino acid sequences of gene
- Mycobrowser
- PATRIC
- BioCyc
- Systems Biology

Amino Acid Sequence

VTQTNRPAFPAGTFSPDPRPNAVPLMLAAQFSLELKLLLRNGEQLLLTMFIPITLLVGLTLLPMGSFGHNRAATFVPVIMALAVISTAFTGQAIAVAFDR
RYGALKRLGATPLPVWGIIAGKSLAVVAVVFLQAIILGAIGFALGWRPALTALTLGAGIIALGTAGFAALGLLLGGTLRAEIVLAVANLMWFVFAGFGAL
TLESNVIPTAFKWVARVTPSGALTEALSQAMTVSVDWFGIVVLAVWGALAALAALRWFRFT

(Nucleotide sequence available on KEGG)

Additional Information

ESSENTIALITY

MtbTnDB - interactive tool for exploring a database of published TnSeq datasets for Mtb

TnSeqCorr - genes with correlated TnSeq profiles across >100 conditions *new*

Classification	Condition	Strain	Method	Reference	Notes
Uncertain	Sodium Oleate	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.965200; 8 non-insertions in a row out of 8 sites
Essential	Lignoceric Acid	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.995550; 8 non-insertions in a row out of 8 sites
Essential	Phosphatidylcholine	H37RvMA	Gumbel	Subhalaxmi Nambi	Probability of Essentiality: 0.995600; 8 non-insertions in a row out of 8 sites
Essential	minimal media + 0.1% glycerol	H37RvMA	Gumbel	Griffin et al. (2011)	Probability of Essentiality: 0.992800; 8 non-insertions in a row out of 8 sites
Essential	minimal media + 0.01% cholesterol	H37RvMA	Gumbel	Griffin et al. (2011)	Probability of Essentiality: 0.992000; 8 non-insertions in a row out of 8 sites
Essential	7H10-glycerol	H37RvMA	TraSH	Sassetti et al. (2003a)
Essential	C57BL/6J mice (8 weeks)	H37RvMA	TraSH	Sassetti et al. (2003b)	Hybridization Ratio: 0.2
Growth-Defect	7H09/7H10 + rich media	H37RvMA	MotifHMM	DeJesus et al. (2017)	Fully saturated (14 reps).

TnSeq Data No data currently available.

No TnSeq data currently available for this Target.

RNASeq Data No data currently available.

No RNA-Seq data currently available for this Target.

Metabolomic Profiles No data currently available.

No Metabolomic data currently available for this Target.

Proteomic Data No data currently available.

No Proteomic data currently available for this Target.

Regulatory Relationships from Systems Biology

BioCyc

Gene interactions based on ChIPSeq and Transcription Factor Over-Expression (TFOE) (Systems Biology)

NOTE: Green edges represent the connected genes being classified as differentially essential as a result of the middle gene being knocked out. These interactions are inferred based on RNASeq.

Interactions based on ChIPSeq data

Binds To:
- No bindings to other targets were found.
Bound By:
- Rv0023 (-)

Interactions based on ChIPSeq data (Minch et al. 2014)

Binds To:
- No bindings to other targets were found.
Bound By:
- Rv0967 (csoR) (Direct binding)
- Rv1816 (-) (Upstream of operon)

Interactions based on TFOE data (Rustad et al. 2014)

Upregulates:
- Does not upregulate other genes.
Upregulated by:
- Not upregulated by other genes.
Downregulates:
- Does not downregulate other genes.
Downregulated by:
- Rv0023 (-)

TBCAP

Tubculosis Community Annotation Project (

Slayden et al., 2013

Rv1457c (-)

Property	Value	Creator	Evidence	PMID	Comment
Interaction	PhysicalInteraction Rv1458c	ashwinigbhat	TAS		Operon (Functional linkage) authors,S. Berg,D. Kaur,M. Jackson,PJ. Brennan The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. Glycobiology 2007
Interaction	PhysicalInteraction Rv1458c	ashwinigbhat	TAS		Operon (Functional linkage) authors,J. Liu,A. Mushegian Three monophyletic superfamilies account for the majority of the known glycosyltransferases. Protein Sci. 2003
Interaction	PhysicalInteraction Rv1458c	ashwinigbhat	TAS		Operon (Functional linkage) AK. Mishra, LJ. Alderwick et al. Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant. Mol. Microbiol. 2008
Interaction	PhysicalInteraction Rv1458c	priti.priety	TAS		Operon (Functional linkage) authors,S. Berg,D. Kaur,M. Jackson,PJ. Brennan The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. Glycobiology 2007
Interaction	PhysicalInteraction Rv1458c	ashwinigbhat	TAS		Operon (Functional linkage) authors,S. Berg,D. Kaur,M. Jackson,PJ. Brennan The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. Glycobiology 2007
Interaction	PhysicalInteraction Rv1459c	ashwinigbhat	TAS		Operon (Functional linkage) authors,S. Berg,D. Kaur,M. Jackson,PJ. Brennan The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. Glycobiology 2007
Interaction	PhysicalInteraction Rv1458c	priti.priety	TAS		Operon (Functional linkage) authors,J. Liu,A. Mushegian Three monophyletic superfamilies account for the majority of the known glycosyltransferases. Protein Sci. 2003
Interaction	PhysicalInteraction Rv1458c	priti.priety	TAS		Operon (Functional linkage) AK. Mishra, LJ. Alderwick et al. Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant. Mol. Microbiol. 2008
Interaction	PhysicalInteraction Rv1459c	ashwinigbhat	TAS		Operon (Functional linkage) authors,J. Liu,A. Mushegian Three monophyletic superfamilies account for the majority of the known glycosyltransferases. Protein Sci. 2003
Citation	Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant. AK. Mishra, LJ. Alderwick et al. Mol. Microbiol. 2008	ashwinigbhat	TAS	18452585	Operon (Functional linkage)
Interaction	PhysicalInteraction Rv1456c	ashwinigbhat	TAS		Operon (Functional linkage) AK. Mishra, LJ. Alderwick et al. Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant. Mol. Microbiol. 2008
Interaction	PhysicalInteraction Rv1458c	ashwinigbhat	TAS		Operon (Functional linkage) AK. Mishra, LJ. Alderwick et al. Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant. Mol. Microbiol. 2008
Interaction	PhysicalInteraction Rv1459c	ashwinigbhat	TAS		Operon (Functional linkage) AK. Mishra, LJ. Alderwick et al. Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant. Mol. Microbiol. 2008
Citation	The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. authors,S. Berg,D. Kaur,M. Jackson,PJ. Brennan Glycobiology 2007	ashwinigbhat	TAS	17261566	Operon (Functional linkage)
Interaction	PhysicalInteraction Rv1456c	ashwinigbhat	TAS		Operon (Functional linkage) authors,S. Berg,D. Kaur,M. Jackson,PJ. Brennan The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. Glycobiology 2007
Interaction	PhysicalInteraction Rv1459c	priti.priety	TAS		Operon (Functional linkage) AK. Mishra, LJ. Alderwick et al. Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant. Mol. Microbiol. 2008
Citation	The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. authors,S. Berg,D. Kaur,M. Jackson,PJ. Brennan Glycobiology 2007	priti.priety	TAS	17261566	Operon (Functional linkage)
Interaction	PhysicalInteraction Rv1456c	priti.priety	TAS		Operon (Functional linkage) authors,S. Berg,D. Kaur,M. Jackson,PJ. Brennan The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. Glycobiology 2007
Interaction	PhysicalInteraction Rv1458c	priti.priety	TAS		Operon (Functional linkage) authors,S. Berg,D. Kaur,M. Jackson,PJ. Brennan The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. Glycobiology 2007
Interaction	PhysicalInteraction Rv1459c	priti.priety	TAS		Operon (Functional linkage) authors,S. Berg,D. Kaur,M. Jackson,PJ. Brennan The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. Glycobiology 2007
Citation	Three monophyletic superfamilies account for the majority of the known glycosyltransferases. authors,J. Liu,A. Mushegian Protein Sci. 2003	ashwinigbhat	TAS	12824488	Operon (Functional linkage)
Interaction	PhysicalInteraction Rv1456c	ashwinigbhat	TAS		Operon (Functional linkage) authors,J. Liu,A. Mushegian Three monophyletic superfamilies account for the majority of the known glycosyltransferases. Protein Sci. 2003
Interaction	PhysicalInteraction Rv1458c	ashwinigbhat	TAS		Operon (Functional linkage) authors,J. Liu,A. Mushegian Three monophyletic superfamilies account for the majority of the known glycosyltransferases. Protein Sci. 2003
Citation	Three monophyletic superfamilies account for the majority of the known glycosyltransferases. authors,J. Liu,A. Mushegian Protein Sci. 2003	priti.priety	TAS	12824488	Operon (Functional linkage)
Interaction	PhysicalInteraction Rv1456c	priti.priety	TAS		Operon (Functional linkage) authors,J. Liu,A. Mushegian Three monophyletic superfamilies account for the majority of the known glycosyltransferases. Protein Sci. 2003
Interaction	PhysicalInteraction Rv1458c	priti.priety	TAS		Operon (Functional linkage) authors,J. Liu,A. Mushegian Three monophyletic superfamilies account for the majority of the known glycosyltransferases. Protein Sci. 2003
Interaction	PhysicalInteraction Rv1459c	priti.priety	TAS		Operon (Functional linkage) authors,J. Liu,A. Mushegian Three monophyletic superfamilies account for the majority of the known glycosyltransferases. Protein Sci. 2003
Citation	Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant. AK. Mishra, LJ. Alderwick et al. Mol. Microbiol. 2008	priti.priety	TAS	18452585	Operon (Functional linkage)
Interaction	PhysicalInteraction Rv1456c	priti.priety	TAS		Operon (Functional linkage) AK. Mishra, LJ. Alderwick et al. Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant. Mol. Microbiol. 2008
Interaction	PhysicalInteraction Rv1458c	priti.priety	TAS		Operon (Functional linkage) AK. Mishra, LJ. Alderwick et al. Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant. Mol. Microbiol. 2008
Interaction	PhysicalInteraction Rv1456c	hibeeluck	TAS		Operon (Functional linkage) authors,M. Braibant,P. Gilot,J. Content The ATP binding cassette (ABC) transport systems of Mycobacterium tuberculosis. FEMS Microbiol. Rev. 2000
Interaction	PhysicalInteraction Rv1456c	hibeeluck	TAS		Operon (Functional linkage) authors,D. Kaur,ME. Guerin,H. Skovierov,PJ. Brennan,M. Jackson Chapter 2: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis. Adv. Appl. Microbiol. 2009
Interaction	PhysicalInteraction Rv1456c	hibeeluck	TAS		Operon (Functional linkage) C. Sala, A. Haouz et al. Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis. Mol. Microbiol. 2009
Interaction	PhysicalInteraction Rv1456c	hibeeluck	TAS		Operon (Functional linkage) AK. Mishra, LJ. Alderwick et al. Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant. Mol. Microbiol. 2008
Interaction	RegulatedBy Rv3911	yamir.moreno	IEP		Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. S. Raman, X. Puyang et al. Mycobacterium tuberculosis SigM positively regulates Esx secreted protein and nonribosomal peptide synthetase genes and down regulates virulence-associated surface lipid synthesis. J. Bacteriol. 2006
Interaction	RegulatedBy Rv0491	yamir.moreno	IEP		Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments.. T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003

Property

Value

Creator

Evidence

PMID

Comment

Interaction

PhysicalInteraction Rv1458c

ashwinigbhat

TAS

Operon (Functional linkage)
authors,S. Berg,D. Kaur,M. Jackson,PJ. Brennan The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. Glycobiology 2007

Interaction

PhysicalInteraction Rv1458c

ashwinigbhat

TAS

Operon (Functional linkage)
authors,J. Liu,A. Mushegian Three monophyletic superfamilies account for the majority of the known glycosyltransferases. Protein Sci. 2003

Interaction

PhysicalInteraction Rv1458c

ashwinigbhat

TAS

Operon (Functional linkage)
AK. Mishra, LJ. Alderwick et al. Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant. Mol. Microbiol. 2008

Interaction

PhysicalInteraction Rv1458c

priti.priety

TAS

Interaction

PhysicalInteraction Rv1458c

ashwinigbhat

TAS

Interaction

PhysicalInteraction Rv1459c

ashwinigbhat

TAS

Interaction

PhysicalInteraction Rv1458c

priti.priety

TAS

Operon (Functional linkage)
authors,J. Liu,A. Mushegian Three monophyletic superfamilies account for the majority of the known glycosyltransferases. Protein Sci. 2003

Interaction

PhysicalInteraction Rv1458c

priti.priety

TAS

Interaction

PhysicalInteraction Rv1459c

ashwinigbhat

TAS

Operon (Functional linkage)
authors,J. Liu,A. Mushegian Three monophyletic superfamilies account for the majority of the known glycosyltransferases. Protein Sci. 2003

Citation

Identification of a novel alpha(1-->6) mannopyranosyltransferase MptB from Corynebacterium glutamicum by deletion of a conserved gene, NCgl1505, affords a lipomannan- and lipoarabinomannan-deficient mutant. AK. Mishra, LJ. Alderwick et al. Mol. Microbiol. 2008

ashwinigbhat

TAS

18452585

Operon (Functional linkage)

Interaction

PhysicalInteraction Rv1456c

ashwinigbhat

TAS

Interaction

PhysicalInteraction Rv1458c

ashwinigbhat

TAS

Interaction

PhysicalInteraction Rv1459c

ashwinigbhat

TAS

Citation

The glycosyltransferases of Mycobacterium tuberculosis - roles in the synthesis of arabinogalactan, lipoarabinomannan, and other glycoconjugates. authors,S. Berg,D. Kaur,M. Jackson,PJ. Brennan Glycobiology 2007

ashwinigbhat

TAS

17261566

Operon (Functional linkage)

Interaction

PhysicalInteraction Rv1456c

ashwinigbhat

TAS

Interaction

PhysicalInteraction Rv1459c

priti.priety

TAS

Citation

priti.priety

TAS

17261566

Operon (Functional linkage)

Interaction

PhysicalInteraction Rv1456c

priti.priety

TAS

Interaction

PhysicalInteraction Rv1458c

priti.priety

TAS

Interaction

PhysicalInteraction Rv1459c

priti.priety

TAS

Citation

Three monophyletic superfamilies account for the majority of the known glycosyltransferases. authors,J. Liu,A. Mushegian Protein Sci. 2003

ashwinigbhat

TAS

12824488

Operon (Functional linkage)

Interaction

PhysicalInteraction Rv1456c

ashwinigbhat

TAS

Operon (Functional linkage)
authors,J. Liu,A. Mushegian Three monophyletic superfamilies account for the majority of the known glycosyltransferases. Protein Sci. 2003

Interaction

PhysicalInteraction Rv1458c

ashwinigbhat

TAS

Operon (Functional linkage)
authors,J. Liu,A. Mushegian Three monophyletic superfamilies account for the majority of the known glycosyltransferases. Protein Sci. 2003

Citation

Three monophyletic superfamilies account for the majority of the known glycosyltransferases. authors,J. Liu,A. Mushegian Protein Sci. 2003

priti.priety

TAS

12824488

Operon (Functional linkage)

Interaction

PhysicalInteraction Rv1456c

priti.priety

TAS

Operon (Functional linkage)
authors,J. Liu,A. Mushegian Three monophyletic superfamilies account for the majority of the known glycosyltransferases. Protein Sci. 2003

Interaction

PhysicalInteraction Rv1458c

priti.priety

TAS

Operon (Functional linkage)
authors,J. Liu,A. Mushegian Three monophyletic superfamilies account for the majority of the known glycosyltransferases. Protein Sci. 2003

Interaction

PhysicalInteraction Rv1459c

priti.priety

TAS

Operon (Functional linkage)
authors,J. Liu,A. Mushegian Three monophyletic superfamilies account for the majority of the known glycosyltransferases. Protein Sci. 2003

Citation

priti.priety

TAS

18452585

Operon (Functional linkage)

Interaction

PhysicalInteraction Rv1456c

priti.priety

TAS

Interaction

PhysicalInteraction Rv1458c

priti.priety

TAS

Interaction

PhysicalInteraction Rv1456c

hibeeluck

TAS

Operon (Functional linkage)
authors,M. Braibant,P. Gilot,J. Content The ATP binding cassette (ABC) transport systems of Mycobacterium tuberculosis. FEMS Microbiol. Rev. 2000

Interaction

PhysicalInteraction Rv1456c

hibeeluck

TAS

Operon (Functional linkage)
authors,D. Kaur,ME. Guerin,H. Skovierov,PJ. Brennan,M. Jackson Chapter 2: Biogenesis of the cell wall and other glycoconjugates of Mycobacterium tuberculosis. Adv. Appl. Microbiol. 2009

Interaction

PhysicalInteraction Rv1456c

hibeeluck

TAS

Operon (Functional linkage)
C. Sala, A. Haouz et al. Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis. Mol. Microbiol. 2009

Interaction

PhysicalInteraction Rv1456c

hibeeluck

TAS

Interaction

RegulatedBy Rv3911

yamir.moreno

IEP

Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
S. Raman, X. Puyang et al. Mycobacterium tuberculosis SigM positively regulates Esx secreted protein and nonribosomal peptide synthetase genes and down regulates virulence-associated surface lipid synthesis. J. Bacteriol. 2006

Interaction

RegulatedBy Rv0491

yamir.moreno

IEP

Microarrays. mRNA levels of regulated element measured and compared between wild-type and trans-element mutation (knockout, over expression etc.) performed by using microarray (or macroarray) experiments..
T. Parish, DA. Smith et al. The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology (Reading, Engl.) 2003

Comments