TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2849c/cobO:

update plot	correlation	link to info on gene
Rv0096/PPE1	(cc=0.5343)	info on Rv0096/PPE1
Rv0926c/-	(cc=0.5293)	info on Rv0926c/-
Rv1473A/-	(cc=0.4935)	info on Rv1473A/-
Rv3867/espH	(cc=0.4797)	info on Rv3867/espH
Rv2734/-	(cc=0.4602)	info on Rv2734/-
Rv1404/-	(cc=0.4452)	info on Rv1404/-
Rv0380c/-	(cc=0.4373)	info on Rv0380c/-
Rv1234/-	(cc=0.4354)	info on Rv1234/-
Rv1972/-	(cc=0.4352)	info on Rv1972/-
Rv0500A/-	(cc=0.4255)	info on Rv0500A/-

Correlation of Rv2849c/cobO with Rv1473A/-

Normalized LFCs for Rv2849c/cobO:
(description and provenance of datasets)

	Rv2849c/cobO	Rv1473A/-
Fe_supp_jason_reseq	0.496	-0.897
low_pH_jason_reseq	0.666	0.291
NO_jason_reseq	0.559	0.719
B6_jason_reseq	-0.613	0.16
MHCII_jason_reseq	-0.393	0.385
Isoniazid02	0.588	0.048
Rifampicin4	0.636	-0.953
Ethambutol3	-0.097	-0.727
Meropenem3	0.189	-0.541
Vancomycin16	0.982	-0.255
Rv2680_day32	-1.007	-0.036
H37Rv_KO_MarP	0.182	-0.103
hypoxia_3wks	0.279	-0.933
hypoxia_6wks	-1.251	0.269
glycerol	-0.459	-0.884
cholesterol	-0.503	0.169
AJ	-0.698	0.64
Bibs02	-0.578	1.286
Bibs02c	-1.085	-1.005
BL6	0.391	2.39
BL6a	-0.023	1.435
BXD01	-0.092	1.282
BXD010	1.328	1.92
BXD011	0.886	1.366
BXD03	1.947	1.353
BXD04	-0.057	1.198
BXD05	1.372	1.913
BXD06	1.034	1.464
BXD07	0.443	1.64
BXD08	0.752	2.033
BXD09	1.233	1.338
CAST	-0.799	0.537
CCcont	-0.238	1.931
DS01	0.053	-0.755
DS02	-0.654	-1.191
DS04	-0.8	-0.656
DS0c	-0.894	-0.693
GP01	-0.672	-0.715
GP02	-0.792	0.658
GP0c	-0.091	-1.093
NOD	-2.792	-1.03
NZO	-2.407	-0.832
PWK	-0.843	-0.054
H37Rv_KO_CtpC	1.092	1.565
H37Rv_KO_CtpD	-1.725	-1.187
H37Rv_KO_Rv1272	0.236	0.584
H37Rv_KO_SugABC	0.374	1.846
H37Rv_KO_MbtN	0.122	-1.155
Trans05	-0.833	0.136
macrophage_unactivated	-0.085	0.193
IL1	0.454	0.258
Rapamycin	1.218	0.721
Tcell	-0.059	0.218
GMCSF	1.824	0.948
IFNab	-0.193	0.511
IFNg	1.221	1.531
IFNg_GMCSF1	1.753	1.326
Rv1432_day32	-0.961	0.343
Rv1565c_day32	-2.96	0.256
secA2_input	0.784	-0.423
delta_Rv3594	0.597	0.231
delta_Rv3717	0.756	0.865
delta_Rv3811	0.097	-0.675
delta_Rv0954	0.978	1.348
PonA1	-1.098	-1.749
EccD1_KO	-0.569	0.237
EspI_KO	1.255	0.856
PE35_KO	1.003	0.648
PPE68_KO	0.234	2.892
glycerol2	-2.14	-0.671
lignocerate	-0.669	0.52
oleate	-2.355	-0.339
phosphatidylcholine	-0.738	-0.057
acetate	-0.642	0.244
glucAc	1.965	0.466
Rv0950ko	0.28	1.031
Rv1096ko	0.914	0.495
Rv3684ko	0.118	-0.082
delta_otsA_trehalose	-0.197	-0.332