TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2849c/cobO:

update plot	correlation	link to info on gene
Rv0096/PPE1	(cc=0.5343)	info on Rv0096/PPE1
Rv0926c/-	(cc=0.5293)	info on Rv0926c/-
Rv1473A/-	(cc=0.4935)	info on Rv1473A/-
Rv3867/espH	(cc=0.4797)	info on Rv3867/espH
Rv2734/-	(cc=0.4602)	info on Rv2734/-
Rv1404/-	(cc=0.4452)	info on Rv1404/-
Rv0380c/-	(cc=0.4373)	info on Rv0380c/-
Rv1234/-	(cc=0.4354)	info on Rv1234/-
Rv1972/-	(cc=0.4352)	info on Rv1972/-
Rv0500A/-	(cc=0.4255)	info on Rv0500A/-

Correlation of Rv2849c/cobO with Rv0926c/-

Normalized LFCs for Rv2849c/cobO:
(description and provenance of datasets)

	Rv2849c/cobO	Rv0926c/-
Fe_supp_jason_reseq	0.496	0.06
low_pH_jason_reseq	0.666	0.519
NO_jason_reseq	0.559	0.05
B6_jason_reseq	-0.613	-0.357
MHCII_jason_reseq	-0.393	0.709
Isoniazid02	0.588	0.895
Rifampicin4	0.636	0.761
Ethambutol3	-0.097	0.927
Meropenem3	0.189	0.022
Vancomycin16	0.982	0.414
Rv2680_day32	-1.007	-1.629
H37Rv_KO_MarP	0.182	0.12
hypoxia_3wks	0.279	-0.104
hypoxia_6wks	-1.251	-1.303
glycerol	-0.459	0.63
cholesterol	-0.503	0.111
AJ	-0.698	-0.629
Bibs02	-0.578	-0.391
Bibs02c	-1.085	-0.899
BL6	0.391	0.28
BL6a	-0.023	0.274
BXD01	-0.092	0.015
BXD010	1.328	0.814
BXD011	0.886	0.753
BXD03	1.947	0.79
BXD04	-0.057	0.552
BXD05	1.372	0.443
BXD06	1.034	0.634
BXD07	0.443	0.638
BXD08	0.752	0.298
BXD09	1.233	0.414
CAST	-0.799	0.474
CCcont	-0.238	0.621
DS01	0.053	-0.224
DS02	-0.654	-0.347
DS04	-0.8	-0.388
DS0c	-0.894	-0.493
GP01	-0.672	-1.476
GP02	-0.792	-0.641
GP0c	-0.091	-0.451
NOD	-2.792	-0.132
NZO	-2.407	0.131
PWK	-0.843	0.108
H37Rv_KO_CtpC	1.092	0.918
H37Rv_KO_CtpD	-1.725	-0.015
H37Rv_KO_Rv1272	0.236	0.25
H37Rv_KO_SugABC	0.374	0.672
H37Rv_KO_MbtN	0.122	-0.657
Trans05	-0.833	0.862
macrophage_unactivated	-0.085	0.35
IL1	0.454	0.353
Rapamycin	1.218	0.838
Tcell	-0.059	-0.088
GMCSF	1.824	1.278
IFNab	-0.193	0.623
IFNg	1.221	1.243
IFNg_GMCSF1	1.753	1.81
Rv1432_day32	-0.961	0.0
Rv1565c_day32	-2.96	-0.112
secA2_input	0.784	0.556
delta_Rv3594	0.597	0.359
delta_Rv3717	0.756	-0.272
delta_Rv3811	0.097	0.0
delta_Rv0954	0.978	0.457
PonA1	-1.098	-0.431
EccD1_KO	-0.569	-0.724
EspI_KO	1.255	0.242
PE35_KO	1.003	-0.403
PPE68_KO	0.234	-0.442
glycerol2	-2.14	0.113
lignocerate	-0.669	-0.196
oleate	-2.355	-0.364
phosphatidylcholine	-0.738	-0.204
acetate	-0.642	-0.023
glucAc	1.965	0.056
Rv0950ko	0.28	1.067
Rv1096ko	0.914	0.754
Rv3684ko	0.118	0.684
delta_otsA_trehalose	-0.197	-0.311