TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1927/-:

update plot	correlation	link to info on gene
Rv0264c/-	(cc=0.5501)	info on Rv0264c/-
Rv0278c/PE_PGRS3	(cc=0.5241)	info on Rv0278c/PE_PGRS3
Rv2577/-	(cc=0.5225)	info on Rv2577/-
Rv2638/-	(cc=0.5099)	info on Rv2638/-
Rv1425/-	(cc=0.5068)	info on Rv1425/-
Rv0964c/-	(cc=0.5021)	info on Rv0964c/-
Rv0536/galE3	(cc=0.4996)	info on Rv0536/galE3
Rv1999c/-	(cc=0.496)	info on Rv1999c/-
Rv2687c/-	(cc=0.4907)	info on Rv2687c/-
Rv0870c/-	(cc=0.4903)	info on Rv0870c/-

Correlation of Rv1927/- with Rv2577/-

Normalized LFCs for Rv1927/-:
(description and provenance of datasets)

	Rv1927/-	Rv2577/-
Fe_supp_jason_reseq	0.009	0.354
low_pH_jason_reseq	-0.458	-0.816
NO_jason_reseq	0.097	0.218
B6_jason_reseq	0.397	0.078
MHCII_jason_reseq	0.468	0.366
Isoniazid02	-0.154	-1.035
Rifampicin4	0.311	0.439
Ethambutol3	0.044	-0.212
Meropenem3	0.119	-1.344
Vancomycin16	1.053	-0.393
Rv2680_day32	0.472	0.214
H37Rv_KO_MarP	-0.161	0.459
hypoxia_3wks	-0.179	0.056
hypoxia_6wks	-0.599	-0.182
glycerol	0.009	-0.467
cholesterol	-0.09	0.31
AJ	0.429	0.439
Bibs02	0.878	0.229
Bibs02c	0.194	0.409
BL6	-0.219	-0.047
BL6a	-0.319	-0.014
BXD01	-0.359	-0.468
BXD010	0.114	-0.13
BXD011	0.141	0.0
BXD03	-0.554	-0.072
BXD04	-0.408	-0.717
BXD05	-0.504	-0.204
BXD06	-0.039	-0.372
BXD07	-0.661	-0.542
BXD08	-0.826	-0.594
BXD09	-0.294	-0.364
CAST	0.073	-0.234
CCcont	-0.226	-0.239
DS01	0.38	0.137
DS02	0.38	-0.523
DS04	0.024	-0.103
DS0c	0.185	-0.099
GP01	-0.226	-0.418
GP02	1.457	0.896
GP0c	-0.197	0.214
NOD	-0.218	-0.519
NZO	0.561	0.198
PWK	0.774	0.431
H37Rv_KO_CtpC	-0.38	-0.332
H37Rv_KO_CtpD	-0.342	0.216
H37Rv_KO_Rv1272	0.371	-0.275
H37Rv_KO_SugABC	-0.512	-0.71
H37Rv_KO_MbtN	-0.993	-0.105
Trans05	0.318	-0.278
macrophage_unactivated	-0.297	-0.234
IL1	0.282	0.036
Rapamycin	-0.025	0.11
Tcell	0.049	-0.495
GMCSF	-0.38	0.124
IFNab	0.136	-0.184
IFNg	0.275	-0.163
IFNg_GMCSF1	-0.321	-0.478
Rv1432_day32	1.199	0.933
Rv1565c_day32	0.046	-0.182
secA2_input	-0.466	0.064
delta_Rv3594	-0.624	0.125
delta_Rv3717	0.345	-0.248
delta_Rv3811	0.283	-0.66
delta_Rv0954	-0.397	-0.056
PonA1	-0.278	-0.384
EccD1_KO	0.0	0.158
EspI_KO	-0.539	0.314
PE35_KO	0.429	0.368
PPE68_KO	0.035	0.205
glycerol2	1.146	0.745
lignocerate	0.95	1.157
oleate	0.509	0.133
phosphatidylcholine	1.305	0.926
acetate	0.387	0.84
glucAc	1.034	0.863
Rv0950ko	0.109	0.739
Rv1096ko	0.109	0.739
Rv3684ko	-0.102	0.393
delta_otsA_trehalose	-0.202	0.753