TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1679/fadE16:

update plot	correlation	link to info on gene
Rv2758c/vapB21	(cc=0.5093)	info on Rv2758c/vapB21
Rv2060/-	(cc=0.4901)	info on Rv2060/-
Rv0945/-	(cc=0.439)	info on Rv0945/-
Rv2813/-	(cc=0.4334)	info on Rv2813/-
Rv0312/-	(cc=0.4329)	info on Rv0312/-
Rv2151c/ftsQ	(cc=0.4325)	info on Rv2151c/ftsQ
Rv2609c/-	(cc=0.4305)	info on Rv2609c/-
Rv2970A/-	(cc=0.4277)	info on Rv2970A/-
Rv2481c/-	(cc=0.4156)	info on Rv2481c/-
Rv1499/-	(cc=0.4152)	info on Rv1499/-

Correlation of Rv1679/fadE16 with Rv2970A/-

Normalized LFCs for Rv1679/fadE16:
(description and provenance of datasets)

	Rv1679/fadE16	Rv2970A/-
Fe_supp_jason_reseq	0.834	1.023
low_pH_jason_reseq	0.214	0.835
NO_jason_reseq	-1.118	-0.572
B6_jason_reseq	-0.198	0.598
MHCII_jason_reseq	-1.309	-1.115
Isoniazid02	0.131	2.002
Rifampicin4	-0.688	0.409
Ethambutol3	-0.524	5.696
Meropenem3	-0.304	0.444
Vancomycin16	0.239	0.846
Rv2680_day32	-1.54	0.715
H37Rv_KO_MarP	-0.528	0.968
hypoxia_3wks	-0.933	-0.778
hypoxia_6wks	0.217	0.766
glycerol	0.78	-0.389
cholesterol	-0.308	0.184
AJ	-1.812	-1.704
Bibs02	-1.537	-1.269
Bibs02c	-1.297	0.303
BL6	-0.034	3.312
BL6a	-0.23	2.184
BXD01	0.926	2.485
BXD010	1.109	1.936
BXD011	0.391	2.424
BXD03	-0.076	2.181
BXD04	-1.039	1.689
BXD05	0.14	3.209
BXD06	0.566	2.483
BXD07	1.248	2.987
BXD08	-1.039	1.885
BXD09	0.075	2.328
CAST	-0.34	0.699
CCcont	1.019	2.221
DS01	-1.348	0.527
DS02	-0.391	-0.866
DS04	-2.025	-1.196
DS0c	-0.949	-0.735
GP01	-1.106	-1.621
GP02	-0.752	-1.116
GP0c	-1.357	-0.156
NOD	-0.89	1.051
NZO	-1.046	-0.62
PWK	-1.532	0.118
H37Rv_KO_CtpC	-2.104	0.293
H37Rv_KO_CtpD	-1.419	0.051
H37Rv_KO_Rv1272	0.282	0.802
H37Rv_KO_SugABC	-1.382	-0.749
H37Rv_KO_MbtN	-1.155	1.533
Trans05	1.838	0.0
macrophage_unactivated	0.682	1.414
IL1	0.136	1.706
Rapamycin	0.141	0.482
Tcell	2.522	0.577
GMCSF	-0.388	0.304
IFNab	-0.768	1.684
IFNg	0.355	0.318
IFNg_GMCSF1	1.156	0.657
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	-0.599
secA2_input	1.166	2.779
delta_Rv3594	0.312	-0.672
delta_Rv3717	0.115	-0.248
delta_Rv3811	0.57	-0.822
delta_Rv0954	-1.649	-2.417
PonA1	-0.712	0.0
EccD1_KO	-0.546	0.099
EspI_KO	-1.01	-0.89
PE35_KO	-0.283	0.058
PPE68_KO	-0.646	-0.032
glycerol2	0.963	0.835
lignocerate	1.685	2.012
oleate	-1.469	0.434
phosphatidylcholine	1.3	1.303
acetate	1.383	1.652
glucAc	1.675	1.092
Rv0950ko	1.375	0.823
Rv1096ko	-0.528	-0.106
Rv3684ko	-0.573	-1.323
delta_otsA_trehalose	-0.103	-1.271