TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1679/fadE16:

update plot	correlation	link to info on gene
Rv2758c/vapB21	(cc=0.5093)	info on Rv2758c/vapB21
Rv2060/-	(cc=0.4901)	info on Rv2060/-
Rv0945/-	(cc=0.439)	info on Rv0945/-
Rv2813/-	(cc=0.4334)	info on Rv2813/-
Rv0312/-	(cc=0.4329)	info on Rv0312/-
Rv2151c/ftsQ	(cc=0.4325)	info on Rv2151c/ftsQ
Rv2609c/-	(cc=0.4305)	info on Rv2609c/-
Rv2970A/-	(cc=0.4277)	info on Rv2970A/-
Rv2481c/-	(cc=0.4156)	info on Rv2481c/-
Rv1499/-	(cc=0.4152)	info on Rv1499/-

Correlation of Rv1679/fadE16 with Rv2481c/-

Normalized LFCs for Rv1679/fadE16:
(description and provenance of datasets)

	Rv1679/fadE16	Rv2481c/-
Fe_supp_jason_reseq	0.834	0.434
low_pH_jason_reseq	0.214	-0.092
NO_jason_reseq	-1.118	-0.593
B6_jason_reseq	-0.198	-0.233
MHCII_jason_reseq	-1.309	-0.51
Isoniazid02	0.131	0.351
Rifampicin4	-0.688	0.024
Ethambutol3	-0.524	0.214
Meropenem3	-0.304	0.055
Vancomycin16	0.239	0.703
Rv2680_day32	-1.54	0.682
H37Rv_KO_MarP	-0.528	-0.497
hypoxia_3wks	-0.933	0.08
hypoxia_6wks	0.217	0.921
glycerol	0.78	0.159
cholesterol	-0.308	0.442
AJ	-1.812	0.321
Bibs02	-1.537	-1.599
Bibs02c	-1.297	0.573
BL6	-0.034	1.853
BL6a	-0.23	1.821
BXD01	0.926	0.866
BXD010	1.109	1.509
BXD011	0.391	1.004
BXD03	-0.076	1.65
BXD04	-1.039	0.4
BXD05	0.14	1.885
BXD06	0.566	1.123
BXD07	1.248	1.091
BXD08	-1.039	1.263
BXD09	0.075	1.301
CAST	-0.34	0.659
CCcont	1.019	1.896
DS01	-1.348	-0.161
DS02	-0.391	0.663
DS04	-2.025	-1.81
DS0c	-0.949	0.347
GP01	-1.106	0.995
GP02	-0.752	1.273
GP0c	-1.357	0.217
NOD	-0.89	0.407
NZO	-1.046	-0.049
PWK	-1.532	0.804
H37Rv_KO_CtpC	-2.104	0.701
H37Rv_KO_CtpD	-1.419	-1.316
H37Rv_KO_Rv1272	0.282	1.848
H37Rv_KO_SugABC	-1.382	-1.683
H37Rv_KO_MbtN	-1.155	0.09
Trans05	1.838	1.478
macrophage_unactivated	0.682	0.445
IL1	0.136	0.478
Rapamycin	0.141	0.359
Tcell	2.522	0.342
GMCSF	-0.388	0.19
IFNab	-0.768	0.366
IFNg	0.355	0.182
IFNg_GMCSF1	1.156	0.201
Rv1432_day32	0.0	0.013
Rv1565c_day32	0.0	-0.142
secA2_input	1.166	-0.509
delta_Rv3594	0.312	0.031
delta_Rv3717	0.115	-1.226
delta_Rv3811	0.57	-0.415
delta_Rv0954	-1.649	-0.849
PonA1	-0.712	-0.911
EccD1_KO	-0.546	0.635
EspI_KO	-1.01	0.508
PE35_KO	-0.283	0.691
PPE68_KO	-0.646	0.781
glycerol2	0.963	1.184
lignocerate	1.685	1.4
oleate	-1.469	0.388
phosphatidylcholine	1.3	1.066
acetate	1.383	0.894
glucAc	1.675	0.948
Rv0950ko	1.375	0.434
Rv1096ko	-0.528	-0.163
Rv3684ko	-0.573	0.252
delta_otsA_trehalose	-0.103	0.873