TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1597/-:

update plot	correlation	link to info on gene
Rv0893c/-	(cc=0.4394)	info on Rv0893c/-
Rv3469c/mhpE	(cc=0.4028)	info on Rv3469c/mhpE
Rv1676/-	(cc=0.3995)	info on Rv1676/-
Rv2821c/-	(cc=0.3926)	info on Rv2821c/-
Rv3758c/proV	(cc=0.386)	info on Rv3758c/proV
Rv3127/-	(cc=0.3805)	info on Rv3127/-
Rv0495c/-	(cc=0.3782)	info on Rv0495c/-
Rv2769c/PE27	(cc=0.3748)	info on Rv2769c/PE27
Rv1103c/mazE3	(cc=0.3741)	info on Rv1103c/mazE3
Rv2641/cadI	(cc=0.3727)	info on Rv2641/cadI

Correlation of Rv1597/- with Rv3758c/proV

Normalized LFCs for Rv1597/-:
(description and provenance of datasets)

	Rv1597/-	Rv3758c/proV
Fe_supp_jason_reseq	0.224	0.096
low_pH_jason_reseq	0.736	-0.393
NO_jason_reseq	0.394	0.312
B6_jason_reseq	0.115	0.084
MHCII_jason_reseq	0.094	-0.766
Isoniazid02	0.589	0.023
Rifampicin4	0.081	-0.376
Ethambutol3	-0.178	0.117
Meropenem3	0.737	0.188
Vancomycin16	0.305	1.263
Rv2680_day32	0.675	0.617
H37Rv_KO_MarP	0.817	0.711
hypoxia_3wks	0.12	0.056
hypoxia_6wks	0.14	0.198
glycerol	0.805	0.671
cholesterol	0.036	0.178
AJ	-0.328	0.108
Bibs02	1.02	0.544
Bibs02c	-0.08	0.677
BL6	1.072	0.634
BL6a	-0.491	-0.023
BXD01	0.11	0.241
BXD010	0.315	0.502
BXD011	-0.041	-0.178
BXD03	0.146	-0.364
BXD04	0.297	-0.867
BXD05	0.05	0.047
BXD06	0.174	-0.065
BXD07	0.165	0.048
BXD08	0.391	0.542
BXD09	0.324	-0.235
CAST	-0.41	-0.14
CCcont	0.467	0.391
DS01	0.626	0.216
DS02	0.258	0.444
DS04	0.887	0.76
DS0c	0.738	0.919
GP01	0.336	1.102
GP02	0.621	-0.083
GP0c	0.551	0.541
NOD	-1.009	-0.605
NZO	-0.156	-0.631
PWK	-0.566	0.283
H37Rv_KO_CtpC	0.366	-0.019
H37Rv_KO_CtpD	0.472	1.574
H37Rv_KO_Rv1272	1.026	0.553
H37Rv_KO_SugABC	-0.327	0.111
H37Rv_KO_MbtN	0.323	0.942
Trans05	0.36	0.228
macrophage_unactivated	-0.704	-0.098
IL1	-0.273	-0.967
Rapamycin	-0.341	-0.344
Tcell	-0.218	-1.062
GMCSF	-0.309	-0.082
IFNab	-0.614	-0.596
IFNg	-0.329	-0.433
IFNg_GMCSF1	-0.408	-0.198
Rv1432_day32	0.708	-0.679
Rv1565c_day32	0.655	-0.122
secA2_input	-0.985	0.26
delta_Rv3594	-0.096	0.407
delta_Rv3717	0.403	0.079
delta_Rv3811	0.381	0.271
delta_Rv0954	0.441	-0.152
PonA1	0.631	0.055
EccD1_KO	0.467	0.069
EspI_KO	0.1	-0.933
PE35_KO	0.298	0.061
PPE68_KO	-0.698	-0.205
glycerol2	0.434	0.212
lignocerate	0.654	0.133
oleate	-0.149	0.14
phosphatidylcholine	0.723	-0.015
acetate	0.46	0.268
glucAc	0.612	-0.024
Rv0950ko	0.19	0.199
Rv1096ko	-0.283	0.576
Rv3684ko	-0.884	0.046
delta_otsA_trehalose	0.585	0.803