TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1597/-:

update plot	correlation	link to info on gene
Rv0893c/-	(cc=0.4394)	info on Rv0893c/-
Rv3469c/mhpE	(cc=0.4028)	info on Rv3469c/mhpE
Rv1676/-	(cc=0.3995)	info on Rv1676/-
Rv2821c/-	(cc=0.3926)	info on Rv2821c/-
Rv3758c/proV	(cc=0.386)	info on Rv3758c/proV
Rv3127/-	(cc=0.3805)	info on Rv3127/-
Rv0495c/-	(cc=0.3782)	info on Rv0495c/-
Rv2769c/PE27	(cc=0.3748)	info on Rv2769c/PE27
Rv1103c/mazE3	(cc=0.3741)	info on Rv1103c/mazE3
Rv2641/cadI	(cc=0.3727)	info on Rv2641/cadI

Correlation of Rv1597/- with Rv2769c/PE27

Normalized LFCs for Rv1597/-:
(description and provenance of datasets)

	Rv1597/-	Rv2769c/PE27
Fe_supp_jason_reseq	0.224	-0.159
low_pH_jason_reseq	0.736	0.306
NO_jason_reseq	0.394	0.48
B6_jason_reseq	0.115	-0.168
MHCII_jason_reseq	0.094	0.118
Isoniazid02	0.589	0.7
Rifampicin4	0.081	0.739
Ethambutol3	-0.178	0.258
Meropenem3	0.737	2.507
Vancomycin16	0.305	0.531
Rv2680_day32	0.675	-0.134
H37Rv_KO_MarP	0.817	0.051
hypoxia_3wks	0.12	-0.136
hypoxia_6wks	0.14	-0.084
glycerol	0.805	0.019
cholesterol	0.036	-0.445
AJ	-0.328	1.082
Bibs02	1.02	0.413
Bibs02c	-0.08	0.049
BL6	1.072	0.584
BL6a	-0.491	-0.133
BXD01	0.11	0.836
BXD010	0.315	0.387
BXD011	-0.041	0.193
BXD03	0.146	-0.139
BXD04	0.297	-0.326
BXD05	0.05	0.583
BXD06	0.174	0.214
BXD07	0.165	-0.052
BXD08	0.391	0.368
BXD09	0.324	0.312
CAST	-0.41	0.225
CCcont	0.467	0.021
DS01	0.626	0.378
DS02	0.258	0.789
DS04	0.887	0.364
DS0c	0.738	0.809
GP01	0.336	0.273
GP02	0.621	0.288
GP0c	0.551	0.419
NOD	-1.009	-0.926
NZO	-0.156	0.637
PWK	-0.566	0.183
H37Rv_KO_CtpC	0.366	-0.201
H37Rv_KO_CtpD	0.472	-0.312
H37Rv_KO_Rv1272	1.026	0.711
H37Rv_KO_SugABC	-0.327	-1.33
H37Rv_KO_MbtN	0.323	0.148
Trans05	0.36	0.448
macrophage_unactivated	-0.704	-0.354
IL1	-0.273	0.018
Rapamycin	-0.341	-0.439
Tcell	-0.218	0.303
GMCSF	-0.309	-0.459
IFNab	-0.614	-0.281
IFNg	-0.329	0.192
IFNg_GMCSF1	-0.408	-0.924
Rv1432_day32	0.708	-0.139
Rv1565c_day32	0.655	0.196
secA2_input	-0.985	-0.235
delta_Rv3594	-0.096	0.493
delta_Rv3717	0.403	0.138
delta_Rv3811	0.381	-0.054
delta_Rv0954	0.441	0.581
PonA1	0.631	0.641
EccD1_KO	0.467	0.151
EspI_KO	0.1	0.556
PE35_KO	0.298	0.198
PPE68_KO	-0.698	0.147
glycerol2	0.434	0.329
lignocerate	0.654	0.497
oleate	-0.149	0.544
phosphatidylcholine	0.723	0.674
acetate	0.46	0.053
glucAc	0.612	-0.105
Rv0950ko	0.19	0.76
Rv1096ko	-0.283	0.32
Rv3684ko	-0.884	0.023
delta_otsA_trehalose	0.585	-0.69