TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1597/-:

update plot	correlation	link to info on gene
Rv0893c/-	(cc=0.4394)	info on Rv0893c/-
Rv3469c/mhpE	(cc=0.4028)	info on Rv3469c/mhpE
Rv1676/-	(cc=0.3995)	info on Rv1676/-
Rv2821c/-	(cc=0.3926)	info on Rv2821c/-
Rv3758c/proV	(cc=0.386)	info on Rv3758c/proV
Rv3127/-	(cc=0.3805)	info on Rv3127/-
Rv0495c/-	(cc=0.3782)	info on Rv0495c/-
Rv2769c/PE27	(cc=0.3748)	info on Rv2769c/PE27
Rv1103c/mazE3	(cc=0.3741)	info on Rv1103c/mazE3
Rv2641/cadI	(cc=0.3727)	info on Rv2641/cadI

Correlation of Rv1597/- with Rv0893c/-

Normalized LFCs for Rv1597/-:
(description and provenance of datasets)

	Rv1597/-	Rv0893c/-
Fe_supp_jason_reseq	0.224	-1.626
low_pH_jason_reseq	0.736	0.448
NO_jason_reseq	0.394	0.953
B6_jason_reseq	0.115	-0.449
MHCII_jason_reseq	0.094	0.189
Isoniazid02	0.589	0.0
Rifampicin4	0.081	0.0
Ethambutol3	-0.178	-0.281
Meropenem3	0.737	-0.435
Vancomycin16	0.305	0.528
Rv2680_day32	0.675	0.337
H37Rv_KO_MarP	0.817	0.26
hypoxia_3wks	0.12	0.183
hypoxia_6wks	0.14	0.691
glycerol	0.805	0.66
cholesterol	0.036	0.358
AJ	-0.328	0.232
Bibs02	1.02	2.078
Bibs02c	-0.08	0.684
BL6	1.072	0.0
BL6a	-0.491	0.544
BXD01	0.11	-0.361
BXD010	0.315	0.513
BXD011	-0.041	0.315
BXD03	0.146	0.664
BXD04	0.297	0.66
BXD05	0.05	1.397
BXD06	0.174	0.401
BXD07	0.165	0.182
BXD08	0.391	-0.431
BXD09	0.324	0.268
CAST	-0.41	0.078
CCcont	0.467	-0.053
DS01	0.626	1.947
DS02	0.258	1.613
DS04	0.887	1.192
DS0c	0.738	1.332
GP01	0.336	-0.715
GP02	0.621	-0.159
GP0c	0.551	0.694
NOD	-1.009	-0.08
NZO	-0.156	0.068
PWK	-0.566	-0.216
H37Rv_KO_CtpC	0.366	1.028
H37Rv_KO_CtpD	0.472	1.658
H37Rv_KO_Rv1272	1.026	1.093
H37Rv_KO_SugABC	-0.327	0.751
H37Rv_KO_MbtN	0.323	-0.24
Trans05	0.36	-0.363
macrophage_unactivated	-0.704	-0.275
IL1	-0.273	-0.258
Rapamycin	-0.341	-0.703
Tcell	-0.218	-0.433
GMCSF	-0.309	-0.605
IFNab	-0.614	0.0
IFNg	-0.329	-0.484
IFNg_GMCSF1	-0.408	-0.88
Rv1432_day32	0.708	0.0
Rv1565c_day32	0.655	0.234
secA2_input	-0.985	-0.787
delta_Rv3594	-0.096	0.616
delta_Rv3717	0.403	-0.185
delta_Rv3811	0.381	0.321
delta_Rv0954	0.441	-0.328
PonA1	0.631	-0.293
EccD1_KO	0.467	0.263
EspI_KO	0.1	0.117
PE35_KO	0.298	0.455
PPE68_KO	-0.698	-0.272
glycerol2	0.434	0.559
lignocerate	0.654	0.913
oleate	-0.149	-0.411
phosphatidylcholine	0.723	0.559
acetate	0.46	0.743
glucAc	0.612	0.605
Rv0950ko	0.19	-0.899
Rv1096ko	-0.283	-0.633
Rv3684ko	-0.884	-1.074
delta_otsA_trehalose	0.585	-0.491