TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1597/-:

update plot	correlation	link to info on gene
Rv0893c/-	(cc=0.4394)	info on Rv0893c/-
Rv3469c/mhpE	(cc=0.4028)	info on Rv3469c/mhpE
Rv1676/-	(cc=0.3995)	info on Rv1676/-
Rv2821c/-	(cc=0.3926)	info on Rv2821c/-
Rv3758c/proV	(cc=0.386)	info on Rv3758c/proV
Rv3127/-	(cc=0.3805)	info on Rv3127/-
Rv0495c/-	(cc=0.3782)	info on Rv0495c/-
Rv2769c/PE27	(cc=0.3748)	info on Rv2769c/PE27
Rv1103c/mazE3	(cc=0.3741)	info on Rv1103c/mazE3
Rv2641/cadI	(cc=0.3727)	info on Rv2641/cadI

Correlation of Rv1597/- with Rv1103c/mazE3

Normalized LFCs for Rv1597/-:
(description and provenance of datasets)

	Rv1597/-	Rv1103c/mazE3
Fe_supp_jason_reseq	0.224	-0.594
low_pH_jason_reseq	0.736	-0.902
NO_jason_reseq	0.394	0.213
B6_jason_reseq	0.115	0.133
MHCII_jason_reseq	0.094	0.223
Isoniazid02	0.589	-0.067
Rifampicin4	0.081	0.152
Ethambutol3	-0.178	-0.213
Meropenem3	0.737	0.217
Vancomycin16	0.305	-0.138
Rv2680_day32	0.675	0.746
H37Rv_KO_MarP	0.817	-0.294
hypoxia_3wks	0.12	-0.136
hypoxia_6wks	0.14	0.898
glycerol	0.805	-0.328
cholesterol	0.036	-0.873
AJ	-0.328	-0.212
Bibs02	1.02	0.29
Bibs02c	-0.08	-0.191
BL6	1.072	0.168
BL6a	-0.491	-0.281
BXD01	0.11	-0.334
BXD010	0.315	-0.512
BXD011	-0.041	-0.171
BXD03	0.146	0.198
BXD04	0.297	0.787
BXD05	0.05	-0.005
BXD06	0.174	-0.366
BXD07	0.165	-0.348
BXD08	0.391	-0.95
BXD09	0.324	0.239
CAST	-0.41	0.224
CCcont	0.467	0.286
DS01	0.626	-0.084
DS02	0.258	-0.199
DS04	0.887	1.228
DS0c	0.738	0.09
GP01	0.336	-0.405
GP02	0.621	0.599
GP0c	0.551	0.347
NOD	-1.009	-1.311
NZO	-0.156	-0.064
PWK	-0.566	0.502
H37Rv_KO_CtpC	0.366	-0.271
H37Rv_KO_CtpD	0.472	0.638
H37Rv_KO_Rv1272	1.026	0.458
H37Rv_KO_SugABC	-0.327	1.39
H37Rv_KO_MbtN	0.323	0.508
Trans05	0.36	0.503
macrophage_unactivated	-0.704	-0.253
IL1	-0.273	0.332
Rapamycin	-0.341	0.644
Tcell	-0.218	-0.515
GMCSF	-0.309	-1.112
IFNab	-0.614	-0.55
IFNg	-0.329	0.016
IFNg_GMCSF1	-0.408	-0.456
Rv1432_day32	0.708	1.095
Rv1565c_day32	0.655	0.689
secA2_input	-0.985	0.188
delta_Rv3594	-0.096	0.797
delta_Rv3717	0.403	0.968
delta_Rv3811	0.381	0.949
delta_Rv0954	0.441	1.762
PonA1	0.631	0.792
EccD1_KO	0.467	-0.201
EspI_KO	0.1	0.61
PE35_KO	0.298	-0.913
PPE68_KO	-0.698	-0.675
glycerol2	0.434	1.767
lignocerate	0.654	2.366
oleate	-0.149	-0.605
phosphatidylcholine	0.723	1.831
acetate	0.46	2.031
glucAc	0.612	2.196
Rv0950ko	0.19	0.271
Rv1096ko	-0.283	0.0
Rv3684ko	-0.884	-0.54
delta_otsA_trehalose	0.585	-0.098