TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1597/-:

update plot	correlation	link to info on gene
Rv0893c/-	(cc=0.4394)	info on Rv0893c/-
Rv3469c/mhpE	(cc=0.4028)	info on Rv3469c/mhpE
Rv1676/-	(cc=0.3995)	info on Rv1676/-
Rv2821c/-	(cc=0.3926)	info on Rv2821c/-
Rv3758c/proV	(cc=0.386)	info on Rv3758c/proV
Rv3127/-	(cc=0.3805)	info on Rv3127/-
Rv0495c/-	(cc=0.3782)	info on Rv0495c/-
Rv2769c/PE27	(cc=0.3748)	info on Rv2769c/PE27
Rv1103c/mazE3	(cc=0.3741)	info on Rv1103c/mazE3
Rv2641/cadI	(cc=0.3727)	info on Rv2641/cadI

Correlation of Rv1597/- with Rv3469c/mhpE

Normalized LFCs for Rv1597/-:
(description and provenance of datasets)

	Rv1597/-	Rv3469c/mhpE
Fe_supp_jason_reseq	0.224	0.638
low_pH_jason_reseq	0.736	0.147
NO_jason_reseq	0.394	0.475
B6_jason_reseq	0.115	-0.681
MHCII_jason_reseq	0.094	-0.486
Isoniazid02	0.589	-0.239
Rifampicin4	0.081	0.317
Ethambutol3	-0.178	-0.277
Meropenem3	0.737	0.401
Vancomycin16	0.305	0.443
Rv2680_day32	0.675	0.177
H37Rv_KO_MarP	0.817	0.412
hypoxia_3wks	0.12	0.183
hypoxia_6wks	0.14	-0.647
glycerol	0.805	0.146
cholesterol	0.036	0.01
AJ	-0.328	-0.459
Bibs02	1.02	-0.518
Bibs02c	-0.08	0.267
BL6	1.072	-0.159
BL6a	-0.491	0.253
BXD01	0.11	0.122
BXD010	0.315	0.029
BXD011	-0.041	-0.412
BXD03	0.146	-0.745
BXD04	0.297	0.29
BXD05	0.05	-0.279
BXD06	0.174	-0.487
BXD07	0.165	-0.365
BXD08	0.391	0.068
BXD09	0.324	-0.357
CAST	-0.41	0.582
CCcont	0.467	-0.117
DS01	0.626	0.394
DS02	0.258	-0.296
DS04	0.887	0.707
DS0c	0.738	0.66
GP01	0.336	0.492
GP02	0.621	1.149
GP0c	0.551	0.305
NOD	-1.009	-0.444
NZO	-0.156	-0.75
PWK	-0.566	-0.354
H37Rv_KO_CtpC	0.366	0.372
H37Rv_KO_CtpD	0.472	0.626
H37Rv_KO_Rv1272	1.026	0.406
H37Rv_KO_SugABC	-0.327	-1.316
H37Rv_KO_MbtN	0.323	-0.636
Trans05	0.36	1.122
macrophage_unactivated	-0.704	-0.663
IL1	-0.273	-1.94
Rapamycin	-0.341	-0.961
Tcell	-0.218	-0.639
GMCSF	-0.309	-0.481
IFNab	-0.614	-1.379
IFNg	-0.329	-1.451
IFNg_GMCSF1	-0.408	-0.277
Rv1432_day32	0.708	0.918
Rv1565c_day32	0.655	-0.704
secA2_input	-0.985	-0.066
delta_Rv3594	-0.096	0.61
delta_Rv3717	0.403	-0.696
delta_Rv3811	0.381	-0.397
delta_Rv0954	0.441	0.129
PonA1	0.631	-0.416
EccD1_KO	0.467	0.625
EspI_KO	0.1	0.339
PE35_KO	0.298	0.394
PPE68_KO	-0.698	0.634
glycerol2	0.434	1.254
lignocerate	0.654	1.344
oleate	-0.149	1.063
phosphatidylcholine	0.723	1.16
acetate	0.46	0.485
glucAc	0.612	0.463
Rv0950ko	0.19	0.021
Rv1096ko	-0.283	-0.169
Rv3684ko	-0.884	-0.138
delta_otsA_trehalose	0.585	-0.244