TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1597/-:

update plot	correlation	link to info on gene
Rv0893c/-	(cc=0.4394)	info on Rv0893c/-
Rv3469c/mhpE	(cc=0.4028)	info on Rv3469c/mhpE
Rv1676/-	(cc=0.3995)	info on Rv1676/-
Rv2821c/-	(cc=0.3926)	info on Rv2821c/-
Rv3758c/proV	(cc=0.386)	info on Rv3758c/proV
Rv3127/-	(cc=0.3805)	info on Rv3127/-
Rv0495c/-	(cc=0.3782)	info on Rv0495c/-
Rv2769c/PE27	(cc=0.3748)	info on Rv2769c/PE27
Rv1103c/mazE3	(cc=0.3741)	info on Rv1103c/mazE3
Rv2641/cadI	(cc=0.3727)	info on Rv2641/cadI

Correlation of Rv1597/- with Rv3127/-

Normalized LFCs for Rv1597/-:
(description and provenance of datasets)

	Rv1597/-	Rv3127/-
Fe_supp_jason_reseq	0.224	0.524
low_pH_jason_reseq	0.736	0.555
NO_jason_reseq	0.394	0.767
B6_jason_reseq	0.115	-0.517
MHCII_jason_reseq	0.094	0.203
Isoniazid02	0.589	-0.194
Rifampicin4	0.081	0.485
Ethambutol3	-0.178	1.054
Meropenem3	0.737	2.889
Vancomycin16	0.305	0.573
Rv2680_day32	0.675	0.383
H37Rv_KO_MarP	0.817	1.082
hypoxia_3wks	0.12	-0.694
hypoxia_6wks	0.14	0.727
glycerol	0.805	-1.009
cholesterol	0.036	-0.338
AJ	-0.328	-0.424
Bibs02	1.02	-1.658
Bibs02c	-0.08	-0.908
BL6	1.072	1.453
BL6a	-0.491	-1.201
BXD01	0.11	0.552
BXD010	0.315	0.678
BXD011	-0.041	0.575
BXD03	0.146	-0.149
BXD04	0.297	0.214
BXD05	0.05	-0.423
BXD06	0.174	-0.277
BXD07	0.165	-0.287
BXD08	0.391	-0.177
BXD09	0.324	-0.656
CAST	-0.41	-0.791
CCcont	0.467	0.772
DS01	0.626	0.722
DS02	0.258	0.525
DS04	0.887	-0.169
DS0c	0.738	0.698
GP01	0.336	-0.801
GP02	0.621	0.637
GP0c	0.551	0.721
NOD	-1.009	-0.195
NZO	-0.156	-0.173
PWK	-0.566	0.232
H37Rv_KO_CtpC	0.366	0.192
H37Rv_KO_CtpD	0.472	0.387
H37Rv_KO_Rv1272	1.026	1.464
H37Rv_KO_SugABC	-0.327	-0.529
H37Rv_KO_MbtN	0.323	0.621
Trans05	0.36	1.161
macrophage_unactivated	-0.704	0.776
IL1	-0.273	-0.308
Rapamycin	-0.341	-0.666
Tcell	-0.218	0.417
GMCSF	-0.309	-0.372
IFNab	-0.614	-0.209
IFNg	-0.329	-0.684
IFNg_GMCSF1	-0.408	-0.933
Rv1432_day32	0.708	0.939
Rv1565c_day32	0.655	0.553
secA2_input	-0.985	-0.418
delta_Rv3594	-0.096	-0.332
delta_Rv3717	0.403	-0.206
delta_Rv3811	0.381	0.239
delta_Rv0954	0.441	-0.584
PonA1	0.631	-1.829
EccD1_KO	0.467	-0.865
EspI_KO	0.1	-0.53
PE35_KO	0.298	-0.064
PPE68_KO	-0.698	0.138
glycerol2	0.434	1.545
lignocerate	0.654	2.115
oleate	-0.149	-0.614
phosphatidylcholine	0.723	1.437
acetate	0.46	1.278
glucAc	0.612	1.483
Rv0950ko	0.19	-0.338
Rv1096ko	-0.283	-0.19
Rv3684ko	-0.884	-0.589
delta_otsA_trehalose	0.585	0.36