TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0903c/prrA:

update plot	correlation	link to info on gene
Rv0380c/-	(cc=0.5505)	info on Rv0380c/-
Rv1129c/-	(cc=0.4786)	info on Rv1129c/-
Rv0545c/pitA	(cc=0.4679)	info on Rv0545c/pitA
Rv2439c/proB	(cc=0.4565)	info on Rv2439c/proB
Rv1193/fadD36	(cc=0.4434)	info on Rv1193/fadD36
Rv0315/-	(cc=0.4403)	info on Rv0315/-
Rv2495c/bkdC	(cc=0.4368)	info on Rv2495c/bkdC
Rv1079/metB	(cc=0.4362)	info on Rv1079/metB
Rv3387/-	(cc=0.433)	info on Rv3387/-
Rv3178/-	(cc=0.4328)	info on Rv3178/-

Correlation of Rv0903c/prrA with Rv2439c/proB

Normalized LFCs for Rv0903c/prrA:
(description and provenance of datasets)

	Rv0903c/prrA	Rv2439c/proB
Fe_supp_jason_reseq	-1.31	-0.766
low_pH_jason_reseq	-2.807	-0.811
NO_jason_reseq	-0.643	-0.914
B6_jason_reseq	-1.11	-0.538
MHCII_jason_reseq	-1.64	-0.474
Isoniazid02	0.178	0.0
Rifampicin4	1.346	0.0
Ethambutol3	0.676	0.0
Meropenem3	1.173	0.0
Vancomycin16	2.109	0.0
Rv2680_day32	0.249	0.0
H37Rv_KO_MarP	-0.865	-0.684
hypoxia_3wks	0.77	0.0
hypoxia_6wks	0.758	0.0
glycerol	0.0	0.0
cholesterol	-0.509	0.0
AJ	-0.815	0.0
Bibs02	-0.642	0.0
Bibs02c	-0.735	0.0
BL6	-0.439	0.0
BL6a	-0.319	0.0
BXD01	-0.328	0.0
BXD010	0.828	0.0
BXD011	0.475	0.0
BXD03	0.356	0.0
BXD04	2.043	0.0
BXD05	0.57	0.0
BXD06	0.863	0.0
BXD07	0.194	0.0
BXD08	0.096	0.0
BXD09	0.285	0.0
CAST	0.0	0.0
CCcont	0.775	0.0
DS01	-0.38	0.0
DS02	-0.35	0.0
DS04	-0.489	0.194
DS0c	0.0	0.0
GP01	-0.249	0.0
GP02	-0.134	0.0
GP0c	0.733	0.0
NOD	-0.361	0.0
NZO	-0.503	0.0
PWK	-0.689	0.0
H37Rv_KO_CtpC	0.427	0.0
H37Rv_KO_CtpD	-0.445	0.0
H37Rv_KO_Rv1272	0.197	0.0
H37Rv_KO_SugABC	-0.348	0.099
H37Rv_KO_MbtN	-0.362	0.0
Trans05	-0.459	0.0
macrophage_unactivated	-0.413	0.0
IL1	1.412	0.0
Rapamycin	0.543	0.0
Tcell	-0.209	0.0
GMCSF	-1.151	0.0
IFNab	0.184	0.0
IFNg	-0.171	0.0
IFNg_GMCSF1	1.049	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	-0.255	0.0
delta_Rv3594	2.634	0.0
delta_Rv3717	0.0	0.0
delta_Rv3811	0.87	0.87
delta_Rv0954	1.47	0.0
PonA1	0.979	0.0
EccD1_KO	-1.194	0.0
EspI_KO	-0.75	0.0
PE35_KO	-0.496	0.0
PPE68_KO	-0.691	0.0
glycerol2	-0.766	0.0
lignocerate	-0.537	0.0
oleate	-0.625	0.0
phosphatidylcholine	-0.618	0.0
acetate	0.56	0.0
glucAc	-0.957	0.0
Rv0950ko	0.856	0.0
Rv1096ko	1.007	0.416
Rv3684ko	1.411	1.588
delta_otsA_trehalose	-0.122	0.0