TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0830/-:

update plot	correlation	link to info on gene
Rv3109/moaA1	(cc=0.5729)	info on Rv3109/moaA1
Rv1087A/-	(cc=0.5419)	info on Rv1087A/-
Rv3738c/PPE66	(cc=0.5249)	info on Rv3738c/PPE66
Rv2267c/-	(cc=0.5247)	info on Rv2267c/-
Rv0755A/-	(cc=0.5195)	info on Rv0755A/-
Rv2424c/-	(cc=0.5054)	info on Rv2424c/-
Rv2958c/-	(cc=0.4928)	info on Rv2958c/-
Rv2092c/helY	(cc=0.4855)	info on Rv2092c/helY
Rv2957/-	(cc=0.4806)	info on Rv2957/-
Rv1916/aceAb	(cc=0.4798)	info on Rv1916/aceAb

Correlation of Rv0830/- with Rv2957/-

Normalized LFCs for Rv0830/-:
(description and provenance of datasets)

	Rv0830/-	Rv2957/-
Fe_supp_jason_reseq	0.148	0.507
low_pH_jason_reseq	-0.279	-0.46
NO_jason_reseq	0.357	-0.018
B6_jason_reseq	0.739	0.052
MHCII_jason_reseq	0.519	0.319
Isoniazid02	-1.003	-0.784
Rifampicin4	0.417	0.417
Ethambutol3	0.027	0.316
Meropenem3	-0.343	-0.769
Vancomycin16	-0.223	-0.17
Rv2680_day32	0.08	0.675
H37Rv_KO_MarP	0.042	0.492
hypoxia_3wks	-0.435	-0.12
hypoxia_6wks	-0.159	-0.236
glycerol	-0.859	-0.018
cholesterol	-0.552	-0.17
AJ	0.481	0.171
Bibs02	0.367	-0.04
Bibs02c	0.202	0.399
BL6	0.037	0.256
BL6a	0.141	0.131
BXD01	0.167	0.434
BXD010	-0.117	0.519
BXD011	-0.097	0.322
BXD03	-0.453	0.536
BXD04	-0.127	0.994
BXD05	0.288	0.11
BXD06	-0.154	0.465
BXD07	-0.126	0.422
BXD08	0.018	0.268
BXD09	-0.004	0.49
CAST	0.21	0.347
CCcont	-0.295	0.191
DS01	-0.258	-0.123
DS02	0.274	0.221
DS04	-0.103	-0.228
DS0c	0.204	0.358
GP01	0.444	0.782
GP02	1.298	0.576
GP0c	-0.138	0.039
NOD	0.205	0.692
NZO	0.285	-0.402
PWK	0.459	0.395
H37Rv_KO_CtpC	0.477	0.936
H37Rv_KO_CtpD	0.225	0.909
H37Rv_KO_Rv1272	0.56	1.143
H37Rv_KO_SugABC	0.499	0.842
H37Rv_KO_MbtN	-0.078	0.76
Trans05	0.684	1.468
macrophage_unactivated	0.237	0.615
IL1	-0.564	-0.329
Rapamycin	-0.292	-0.307
Tcell	0.274	-0.476
GMCSF	0.185	-0.869
IFNab	-0.19	-0.115
IFNg	-0.211	0.139
IFNg_GMCSF1	-0.066	-0.478
Rv1432_day32	0.023	0.01
Rv1565c_day32	0.242	0.0
secA2_input	-0.204	0.114
delta_Rv3594	-0.341	0.061
delta_Rv3717	-0.507	-0.609
delta_Rv3811	-0.656	0.0
delta_Rv0954	-0.682	-0.561
PonA1	-0.446	-0.38
EccD1_KO	0.967	0.51
EspI_KO	0.034	0.853
PE35_KO	-0.067	1.103
PPE68_KO	0.643	0.745
glycerol2	0.409	0.303
lignocerate	0.269	0.247
oleate	0.668	0.251
phosphatidylcholine	0.655	0.356
acetate	-0.136	-0.318
glucAc	-0.005	-0.209
Rv0950ko	0.28	0.666
Rv1096ko	-0.401	-0.344
Rv3684ko	-0.229	0.131
delta_otsA_trehalose	0.579	-0.462