TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0771/-:

update plot	correlation	link to info on gene
Rv0306/-	(cc=0.5274)	info on Rv0306/-
Rv3032/-	(cc=0.5215)	info on Rv3032/-
Rv1208/gpgS	(cc=0.5165)	info on Rv1208/gpgS
Rv2424c/-	(cc=0.4995)	info on Rv2424c/-
Rv0084/hycD	(cc=0.4796)	info on Rv0084/hycD
Rv2306B/-	(cc=0.4762)	info on Rv2306B/-
Rv2980/-	(cc=0.4756)	info on Rv2980/-
Rv3055/-	(cc=0.4717)	info on Rv3055/-
Rv1153c/omt	(cc=0.4498)	info on Rv1153c/omt
Rv3548c/-	(cc=0.4462)	info on Rv3548c/-

Correlation of Rv0771/- with Rv1153c/omt

Normalized LFCs for Rv0771/-:
(description and provenance of datasets)

	Rv0771/-	Rv1153c/omt
Fe_supp_jason_reseq	0.077	-1.021
low_pH_jason_reseq	0.266	-0.504
NO_jason_reseq	-0.517	0.158
B6_jason_reseq	0.257	-0.436
MHCII_jason_reseq	0.977	-0.542
Isoniazid02	0.259	-0.739
Rifampicin4	0.046	0.154
Ethambutol3	-0.562	-0.81
Meropenem3	-0.242	-0.902
Vancomycin16	1.398	-0.462
Rv2680_day32	-0.281	0.007
H37Rv_KO_MarP	0.436	0.051
hypoxia_3wks	0.275	-0.223
hypoxia_6wks	0.47	-0.196
glycerol	-1.498	-0.08
cholesterol	-1.152	-0.343
AJ	0.746	0.012
Bibs02	0.634	0.277
Bibs02c	-0.456	-0.382
BL6	1.053	-0.823
BL6a	-0.105	-0.1
BXD01	0.581	-0.093
BXD010	0.338	0.092
BXD011	0.284	0.025
BXD03	-0.239	0.256
BXD04	0.714	0.303
BXD05	0.142	0.249
BXD06	0.192	0.202
BXD07	0.428	0.345
BXD08	0.775	0.207
BXD09	0.116	0.132
CAST	-0.43	-0.023
CCcont	0.616	-0.468
DS01	-0.347	-0.39
DS02	-0.769	-0.167
DS04	0.221	0.121
DS0c	0.074	0.223
GP01	0.178	-0.265
GP02	-0.948	-0.459
GP0c	-0.284	-0.707
NOD	0.076	0.291
NZO	0.539	0.497
PWK	0.854	0.489
H37Rv_KO_CtpC	-0.115	0.124
H37Rv_KO_CtpD	-1.731	0.018
H37Rv_KO_Rv1272	0.012	-0.17
H37Rv_KO_SugABC	0.05	0.137
H37Rv_KO_MbtN	-1.027	-0.47
Trans05	0.149	-0.179
macrophage_unactivated	-0.129	-0.382
IL1	-0.851	-0.074
Rapamycin	0.353	-0.371
Tcell	-0.935	-0.121
GMCSF	0.106	-0.459
IFNab	-0.218	-0.094
IFNg	-0.834	-0.166
IFNg_GMCSF1	-0.031	0.038
Rv1432_day32	-0.083	0.13
Rv1565c_day32	0.523	0.043
secA2_input	0.0	0.255
delta_Rv3594	0.991	-0.274
delta_Rv3717	-0.17	-0.701
delta_Rv3811	-0.272	-0.784
delta_Rv0954	-0.509	-0.788
PonA1	0.0	-0.679
EccD1_KO	1.345	0.74
EspI_KO	2.227	0.545
PE35_KO	1.878	0.963
PPE68_KO	2.665	0.928
glycerol2	0.814	0.345
lignocerate	0.816	0.493
oleate	0.713	0.096
phosphatidylcholine	1.035	0.7
acetate	0.776	0.191
glucAc	0.539	0.051
Rv0950ko	-0.106	-0.392
Rv1096ko	1.381	0.335
Rv3684ko	0.056	0.282
delta_otsA_trehalose	0.687	1.595