TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0740/-:

update plot	correlation	link to info on gene
Rv2644c/-	(cc=0.5214)	info on Rv2644c/-
Rv1574/-	(cc=0.5195)	info on Rv1574/-
Rv0584/-	(cc=0.4592)	info on Rv0584/-
Rv2848c/cobB	(cc=0.4519)	info on Rv2848c/cobB
Rv3175/-	(cc=0.4435)	info on Rv3175/-
Rv0926c/-	(cc=0.4291)	info on Rv0926c/-
Rv0902c/prrB	(cc=0.427)	info on Rv0902c/prrB
Rv0601c/-	(cc=0.4226)	info on Rv0601c/-
Rv0204c/-	(cc=0.418)	info on Rv0204c/-
Rv2901c/-	(cc=0.4103)	info on Rv2901c/-

Correlation of Rv0740/- with Rv2848c/cobB

Normalized LFCs for Rv0740/-:
(description and provenance of datasets)

	Rv0740/-	Rv2848c/cobB
Fe_supp_jason_reseq	0.069	0.66
low_pH_jason_reseq	1.802	-0.212
NO_jason_reseq	0.774	0.071
B6_jason_reseq	1.02	0.274
MHCII_jason_reseq	0.233	0.558
Isoniazid02	0.989	1.521
Rifampicin4	0.087	0.72
Ethambutol3	1.16	1.454
Meropenem3	0.688	0.187
Vancomycin16	0.17	0.706
Rv2680_day32	-1.013	-0.633
H37Rv_KO_MarP	-0.027	-0.161
hypoxia_3wks	-1.854	0.263
hypoxia_6wks	-1.063	-0.035
glycerol	-1.09	0.426
cholesterol	-0.158	0.385
AJ	-0.345	0.521
Bibs02	-0.901	0.534
Bibs02c	-0.203	0.303
BL6	0.712	0.39
BL6a	0.089	-0.034
BXD01	0.428	-0.805
BXD010	-0.781	-1.385
BXD011	0.235	-0.787
BXD03	0.197	-0.372
BXD04	0.826	-0.708
BXD05	0.525	-0.832
BXD06	0.031	-0.705
BXD07	0.557	-1.089
BXD08	0.465	-0.251
BXD09	-0.218	-1.055
CAST	0.566	0.02
CCcont	0.195	-0.497
DS01	0.296	0.58
DS02	0.147	0.799
DS04	0.358	0.748
DS0c	0.347	0.487
GP01	-1.157	-0.741
GP02	-0.877	-0.257
GP0c	-0.753	-0.167
NOD	0.039	-0.334
NZO	-1.503	0.212
PWK	-0.215	0.342
H37Rv_KO_CtpC	-1.662	-0.324
H37Rv_KO_CtpD	0.264	-0.067
H37Rv_KO_Rv1272	-0.317	-0.372
H37Rv_KO_SugABC	-0.969	-1.675
H37Rv_KO_MbtN	-0.706	-1.399
Trans05	-0.284	-0.419
macrophage_unactivated	1.925	2.071
IL1	0.406	2.948
Rapamycin	1.178	2.627
Tcell	-0.147	-4.822
GMCSF	0.689	2.986
IFNab	0.29	3.223
IFNg	1.267	2.881
IFNg_GMCSF1	3.02	4.342
Rv1432_day32	-0.222	-0.257
Rv1565c_day32	-1.579	0.134
secA2_input	-1.105	1.061
delta_Rv3594	-1.444	-0.199
delta_Rv3717	-0.789	-0.273
delta_Rv3811	-1.022	-1.05
delta_Rv0954	0.15	-0.696
PonA1	-0.668	0.17
EccD1_KO	-0.141	-0.122
EspI_KO	0.0	0.103
PE35_KO	0.216	0.863
PPE68_KO	0.186	0.39
glycerol2	-0.129	0.475
lignocerate	0.0	0.66
oleate	-1.602	0.2
phosphatidylcholine	-0.384	0.675
acetate	0.69	1.714
glucAc	0.868	0.59
Rv0950ko	-0.292	-0.199
Rv1096ko	0.407	0.507
Rv3684ko	-0.183	-1.068
delta_otsA_trehalose	-0.138	0.322