TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0740/-:

update plot	correlation	link to info on gene
Rv2644c/-	(cc=0.5214)	info on Rv2644c/-
Rv1574/-	(cc=0.5195)	info on Rv1574/-
Rv0584/-	(cc=0.4592)	info on Rv0584/-
Rv2848c/cobB	(cc=0.4519)	info on Rv2848c/cobB
Rv3175/-	(cc=0.4435)	info on Rv3175/-
Rv0926c/-	(cc=0.4291)	info on Rv0926c/-
Rv0902c/prrB	(cc=0.427)	info on Rv0902c/prrB
Rv0601c/-	(cc=0.4226)	info on Rv0601c/-
Rv0204c/-	(cc=0.418)	info on Rv0204c/-
Rv2901c/-	(cc=0.4103)	info on Rv2901c/-

Correlation of Rv0740/- with Rv1574/-

Normalized LFCs for Rv0740/-:
(description and provenance of datasets)

	Rv0740/-	Rv1574/-
Fe_supp_jason_reseq	0.069	1.146
low_pH_jason_reseq	1.802	0.785
NO_jason_reseq	0.774	-0.465
B6_jason_reseq	1.02	1.2
MHCII_jason_reseq	0.233	0.378
Isoniazid02	0.989	0.351
Rifampicin4	0.087	0.341
Ethambutol3	1.16	0.293
Meropenem3	0.688	3.363
Vancomycin16	0.17	0.639
Rv2680_day32	-1.013	-1.997
H37Rv_KO_MarP	-0.027	-2.994
hypoxia_3wks	-1.854	0.0
hypoxia_6wks	-1.063	0.77
glycerol	-1.09	-1.024
cholesterol	-0.158	-0.475
AJ	-0.345	1.585
Bibs02	-0.901	0.725
Bibs02c	-0.203	-0.467
BL6	0.712	2.01
BL6a	0.089	0.227
BXD01	0.428	1.367
BXD010	-0.781	1.662
BXD011	0.235	-0.418
BXD03	0.197	0.249
BXD04	0.826	2.507
BXD05	0.525	-0.369
BXD06	0.031	0.765
BXD07	0.557	0.728
BXD08	0.465	1.454
BXD09	-0.218	0.109
CAST	0.566	0.913
CCcont	0.195	1.886
DS01	0.296	0.092
DS02	0.147	1.297
DS04	0.358	0.357
DS0c	0.347	-1.248
GP01	-1.157	-0.986
GP02	-0.877	-0.831
GP0c	-0.753	-1.299
NOD	0.039	0.257
NZO	-1.503	-1.011
PWK	-0.215	-0.644
H37Rv_KO_CtpC	-1.662	-1.623
H37Rv_KO_CtpD	0.264	-0.729
H37Rv_KO_Rv1272	-0.317	1.674
H37Rv_KO_SugABC	-0.969	-0.89
H37Rv_KO_MbtN	-0.706	0.38
Trans05	-0.284	0.718
macrophage_unactivated	1.925	1.174
IL1	0.406	1.198
Rapamycin	1.178	1.142
Tcell	-0.147	0.398
GMCSF	0.689	1.312
IFNab	0.29	1.318
IFNg	1.267	-0.355
IFNg_GMCSF1	3.02	2.181
Rv1432_day32	-0.222	0.18
Rv1565c_day32	-1.579	-3.216
secA2_input	-1.105	-4.156
delta_Rv3594	-1.444	-2.169
delta_Rv3717	-0.789	-4.501
delta_Rv3811	-1.022	-4.497
delta_Rv0954	0.15	-2.702
PonA1	-0.668	-2.581
EccD1_KO	-0.141	0.881
EspI_KO	0.0	1.477
PE35_KO	0.216	1.832
PPE68_KO	0.186	2.4
glycerol2	-0.129	2.221
lignocerate	0.0	2.297
oleate	-1.602	-1.704
phosphatidylcholine	-0.384	2.004
acetate	0.69	3.401
glucAc	0.868	2.883
Rv0950ko	-0.292	-0.392
Rv1096ko	0.407	-1.405
Rv3684ko	-0.183	1.398
delta_otsA_trehalose	-0.138	0.0