TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0740/-:

update plot	correlation	link to info on gene
Rv2644c/-	(cc=0.5214)	info on Rv2644c/-
Rv1574/-	(cc=0.5195)	info on Rv1574/-
Rv0584/-	(cc=0.4592)	info on Rv0584/-
Rv2848c/cobB	(cc=0.4519)	info on Rv2848c/cobB
Rv3175/-	(cc=0.4435)	info on Rv3175/-
Rv0926c/-	(cc=0.4291)	info on Rv0926c/-
Rv0902c/prrB	(cc=0.427)	info on Rv0902c/prrB
Rv0601c/-	(cc=0.4226)	info on Rv0601c/-
Rv0204c/-	(cc=0.418)	info on Rv0204c/-
Rv2901c/-	(cc=0.4103)	info on Rv2901c/-

Correlation of Rv0740/- with Rv0601c/-

Normalized LFCs for Rv0740/-:
(description and provenance of datasets)

	Rv0740/-	Rv0601c/-
Fe_supp_jason_reseq	0.069	1.601
low_pH_jason_reseq	1.802	0.898
NO_jason_reseq	0.774	2.024
B6_jason_reseq	1.02	2.532
MHCII_jason_reseq	0.233	1.891
Isoniazid02	0.989	1.088
Rifampicin4	0.087	0.777
Ethambutol3	1.16	-0.185
Meropenem3	0.688	0.068
Vancomycin16	0.17	1.395
Rv2680_day32	-1.013	1.998
H37Rv_KO_MarP	-0.027	0.718
hypoxia_3wks	-1.854	-0.06
hypoxia_6wks	-1.063	1.222
glycerol	-1.09	0.456
cholesterol	-0.158	0.256
AJ	-0.345	-0.351
Bibs02	-0.901	0.368
Bibs02c	-0.203	1.217
BL6	0.712	-2.428
BL6a	0.089	0.835
BXD01	0.428	-1.118
BXD010	-0.781	-0.776
BXD011	0.235	-0.583
BXD03	0.197	-0.95
BXD04	0.826	-0.816
BXD05	0.525	0.0
BXD06	0.031	-0.081
BXD07	0.557	-0.557
BXD08	0.465	-1.717
BXD09	-0.218	-0.086
CAST	0.566	0.641
CCcont	0.195	-0.617
DS01	0.296	0.548
DS02	0.147	0.126
DS04	0.358	2.599
DS0c	0.347	0.314
GP01	-1.157	-1.827
GP02	-0.877	-2.143
GP0c	-0.753	-1.094
NOD	0.039	2.018
NZO	-1.503	-0.737
PWK	-0.215	-0.789
H37Rv_KO_CtpC	-1.662	-1.118
H37Rv_KO_CtpD	0.264	-2.459
H37Rv_KO_Rv1272	-0.317	-2.492
H37Rv_KO_SugABC	-0.969	-1.877
H37Rv_KO_MbtN	-0.706	-2.414
Trans05	-0.284	-0.111
macrophage_unactivated	1.925	2.541
IL1	0.406	1.373
Rapamycin	1.178	1.921
Tcell	-0.147	0.31
GMCSF	0.689	0.644
IFNab	0.29	0.774
IFNg	1.267	0.425
IFNg_GMCSF1	3.02	2.555
Rv1432_day32	-0.222	0.0
Rv1565c_day32	-1.579	-1.267
secA2_input	-1.105	0.543
delta_Rv3594	-1.444	-0.802
delta_Rv3717	-0.789	0.274
delta_Rv3811	-1.022	0.726
delta_Rv0954	0.15	0.098
PonA1	-0.668	0.792
EccD1_KO	-0.141	0.97
EspI_KO	0.0	0.183
PE35_KO	0.216	-1.843
PPE68_KO	0.186	-0.534
glycerol2	-0.129	-0.581
lignocerate	0.0	0.751
oleate	-1.602	-2.579
phosphatidylcholine	-0.384	0.161
acetate	0.69	1.077
glucAc	0.868	0.806
Rv0950ko	-0.292	0.175
Rv1096ko	0.407	0.657
Rv3684ko	-0.183	-0.298
delta_otsA_trehalose	-0.138	0.084