TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0674/-:

update plot	correlation	link to info on gene
Rv1453/-	(cc=0.5891)	info on Rv1453/-
Rv0901/-	(cc=0.5708)	info on Rv0901/-
Rv0218/-	(cc=0.5667)	info on Rv0218/-
Rv3637/-	(cc=0.5633)	info on Rv3637/-
Rv3401/-	(cc=0.563)	info on Rv3401/-
Rv1181/pks4	(cc=0.5386)	info on Rv1181/pks4
Rv0233/nrdB	(cc=0.5312)	info on Rv0233/nrdB
Rv2915c/-	(cc=0.5309)	info on Rv2915c/-
Rv2867c/-	(cc=0.5286)	info on Rv2867c/-
Rv2974c/-	(cc=0.5188)	info on Rv2974c/-

Correlation of Rv0674/- with Rv2974c/-

Normalized LFCs for Rv0674/-:
(description and provenance of datasets)

	Rv0674/-	Rv2974c/-
Fe_supp_jason_reseq	-0.863	0.166
low_pH_jason_reseq	-0.915	-1.497
NO_jason_reseq	0.194	-0.071
B6_jason_reseq	1.023	0.326
MHCII_jason_reseq	1.392	0.09
Isoniazid02	-0.108	0.186
Rifampicin4	0.712	1.134
Ethambutol3	1.031	0.683
Meropenem3	0.642	1.423
Vancomycin16	0.698	0.422
Rv2680_day32	0.0	0.458
H37Rv_KO_MarP	-0.145	-0.337
hypoxia_3wks	0.459	0.0
hypoxia_6wks	-1.625	-0.539
glycerol	0.878	1.258
cholesterol	0.694	0.797
AJ	0.077	0.477
Bibs02	1.025	0.723
Bibs02c	-0.302	-0.676
BL6	-1.479	-0.419
BL6a	-1.964	-0.933
BXD01	-1.54	-0.53
BXD010	-0.459	-0.032
BXD011	-0.88	-0.472
BXD03	-0.094	-0.304
BXD04	-1.339	-0.108
BXD05	-1.457	-0.466
BXD06	-0.543	-0.739
BXD07	-1.373	-0.37
BXD08	-1.105	0.355
BXD09	-0.719	-0.662
CAST	-0.938	0.344
CCcont	-1.481	-0.118
DS01	0.974	0.676
DS02	0.635	0.756
DS04	1.27	0.71
DS0c	0.943	0.781
GP01	-1.167	-0.682
GP02	-0.984	0.343
GP0c	-1.537	-0.044
NOD	-0.6	-0.197
NZO	0.192	0.146
PWK	-0.136	-0.067
H37Rv_KO_CtpC	-1.92	0.157
H37Rv_KO_CtpD	-1.497	0.933
H37Rv_KO_Rv1272	-1.172	-0.456
H37Rv_KO_SugABC	-1.073	0.644
H37Rv_KO_MbtN	-1.116	-0.299
Trans05	-1.296	-0.176
macrophage_unactivated	-2.058	-1.016
IL1	-1.361	-0.647
Rapamycin	0.0	-0.669
Tcell	-1.906	-0.71
GMCSF	-2.308	-0.665
IFNab	-1.575	-0.088
IFNg	-0.497	-1.008
IFNg_GMCSF1	-1.637	-0.632
Rv1432_day32	0.0	0.79
Rv1565c_day32	-0.305	-0.12
secA2_input	-0.258	0.063
delta_Rv3594	-2.385	0.116
delta_Rv3717	-2.796	0.109
delta_Rv3811	-0.947	-0.173
delta_Rv0954	-1.828	-0.103
PonA1	-0.931	0.217
EccD1_KO	-0.898	-0.033
EspI_KO	0.14	-0.06
PE35_KO	-0.796	-0.411
PPE68_KO	-1.491	-0.56
glycerol2	-1.188	-0.412
lignocerate	-1.033	-0.102
oleate	-1.202	-0.198
phosphatidylcholine	-0.994	0.098
acetate	-1.41	0.228
glucAc	-0.877	-0.191
Rv0950ko	-1.631	0.075
Rv1096ko	0.133	0.495
Rv3684ko	-0.982	0.609
delta_otsA_trehalose	0.564	-0.574