TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0674/-:

update plot	correlation	link to info on gene
Rv1453/-	(cc=0.5891)	info on Rv1453/-
Rv0901/-	(cc=0.5708)	info on Rv0901/-
Rv0218/-	(cc=0.5667)	info on Rv0218/-
Rv3637/-	(cc=0.5633)	info on Rv3637/-
Rv3401/-	(cc=0.563)	info on Rv3401/-
Rv1181/pks4	(cc=0.5386)	info on Rv1181/pks4
Rv0233/nrdB	(cc=0.5312)	info on Rv0233/nrdB
Rv2915c/-	(cc=0.5309)	info on Rv2915c/-
Rv2867c/-	(cc=0.5286)	info on Rv2867c/-
Rv2974c/-	(cc=0.5188)	info on Rv2974c/-

Correlation of Rv0674/- with Rv0218/-

Normalized LFCs for Rv0674/-:
(description and provenance of datasets)

	Rv0674/-	Rv0218/-
Fe_supp_jason_reseq	-0.863	0.434
low_pH_jason_reseq	-0.915	-0.201
NO_jason_reseq	0.194	0.0
B6_jason_reseq	1.023	0.84
MHCII_jason_reseq	1.392	1.098
Isoniazid02	-0.108	1.369
Rifampicin4	0.712	0.582
Ethambutol3	1.031	0.991
Meropenem3	0.642	0.0
Vancomycin16	0.698	0.658
Rv2680_day32	0.0	-0.208
H37Rv_KO_MarP	-0.145	0.203
hypoxia_3wks	0.459	0.251
hypoxia_6wks	-1.625	0.106
glycerol	0.878	1.104
cholesterol	0.694	0.912
AJ	0.077	0.734
Bibs02	1.025	0.09
Bibs02c	-0.302	0.537
BL6	-1.479	-0.272
BL6a	-1.964	0.043
BXD01	-1.54	-0.43
BXD010	-0.459	-0.722
BXD011	-0.88	0.009
BXD03	-0.094	-0.419
BXD04	-1.339	-0.445
BXD05	-1.457	0.322
BXD06	-0.543	-0.467
BXD07	-1.373	-0.416
BXD08	-1.105	-0.4
BXD09	-0.719	-0.343
CAST	-0.938	0.385
CCcont	-1.481	-0.716
DS01	0.974	0.245
DS02	0.635	0.792
DS04	1.27	0.95
DS0c	0.943	0.641
GP01	-1.167	-1.051
GP02	-0.984	0.232
GP0c	-1.537	-0.537
NOD	-0.6	0.747
NZO	0.192	-0.15
PWK	-0.136	0.735
H37Rv_KO_CtpC	-1.92	-0.473
H37Rv_KO_CtpD	-1.497	-0.762
H37Rv_KO_Rv1272	-1.172	0.484
H37Rv_KO_SugABC	-1.073	0.485
H37Rv_KO_MbtN	-1.116	-0.703
Trans05	-1.296	-0.485
macrophage_unactivated	-2.058	-1.209
IL1	-1.361	-0.11
Rapamycin	0.0	-0.592
Tcell	-1.906	-0.811
GMCSF	-2.308	-0.296
IFNab	-1.575	-0.499
IFNg	-0.497	0.187
IFNg_GMCSF1	-1.637	-0.075
Rv1432_day32	0.0	0.439
Rv1565c_day32	-0.305	1.077
secA2_input	-0.258	-0.421
delta_Rv3594	-2.385	-0.272
delta_Rv3717	-2.796	-0.152
delta_Rv3811	-0.947	-0.18
delta_Rv0954	-1.828	0.469
PonA1	-0.931	0.372
EccD1_KO	-0.898	-0.365
EspI_KO	0.14	-0.228
PE35_KO	-0.796	0.193
PPE68_KO	-1.491	-0.221
glycerol2	-1.188	-0.433
lignocerate	-1.033	-0.61
oleate	-1.202	0.231
phosphatidylcholine	-0.994	-0.364
acetate	-1.41	-0.653
glucAc	-0.877	-0.818
Rv0950ko	-1.631	0.0
Rv1096ko	0.133	-0.271
Rv3684ko	-0.982	-0.295
delta_otsA_trehalose	0.564	-0.376