TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0557/mgtA:

update plot	correlation	link to info on gene
Rv0375c/-	(cc=0.4927)	info on Rv0375c/-
Rv2384/mbtA	(cc=0.4529)	info on Rv2384/mbtA
Rv2998/-	(cc=0.4462)	info on Rv2998/-
Rv3636/-	(cc=0.4454)	info on Rv3636/-
Rv3334/-	(cc=0.4376)	info on Rv3334/-
Rv1060/-	(cc=0.4357)	info on Rv1060/-
Rv2484c/-	(cc=0.4303)	info on Rv2484c/-
Rv0869c/moaA2	(cc=0.4292)	info on Rv0869c/moaA2
Rv0274/-	(cc=0.4018)	info on Rv0274/-
Rv0044c/-	(cc=0.3889)	info on Rv0044c/-

Correlation of Rv0557/mgtA with Rv0044c/-

Normalized LFCs for Rv0557/mgtA:
(description and provenance of datasets)

	Rv0557/mgtA	Rv0044c/-
Fe_supp_jason_reseq	0.0	0.218
low_pH_jason_reseq	0.341	0.04
NO_jason_reseq	-0.488	-0.47
B6_jason_reseq	0.532	0.346
MHCII_jason_reseq	-0.232	0.656
Isoniazid02	0.65	0.141
Rifampicin4	0.173	0.742
Ethambutol3	0.423	0.804
Meropenem3	-0.254	1.108
Vancomycin16	1.313	0.825
Rv2680_day32	-2.937	-1.564
H37Rv_KO_MarP	0.94	0.405
hypoxia_3wks	0.207	-0.032
hypoxia_6wks	-0.474	0.165
glycerol	0.275	0.218
cholesterol	0.478	-0.154
AJ	-0.237	-0.217
Bibs02	-1.462	0.293
Bibs02c	-0.579	0.377
BL6	0.58	0.419
BL6a	-0.611	-0.098
BXD01	-0.065	-0.228
BXD010	-0.315	-0.171
BXD011	-0.571	-0.513
BXD03	-0.606	-0.247
BXD04	0.341	0.242
BXD05	0.064	0.222
BXD06	-0.456	-0.161
BXD07	0.482	-0.233
BXD08	0.093	-0.091
BXD09	-0.181	-0.16
CAST	0.881	0.082
CCcont	-0.785	-0.159
DS01	-0.371	0.496
DS02	0.432	0.446
DS04	0.676	0.069
DS0c	0.152	0.57
GP01	-0.049	0.236
GP02	-0.916	-0.35
GP0c	-0.489	-0.113
NOD	0.158	0.093
NZO	-0.552	0.172
PWK	-0.148	0.294
H37Rv_KO_CtpC	-0.611	0.365
H37Rv_KO_CtpD	-1.689	0.222
H37Rv_KO_Rv1272	1.105	0.065
H37Rv_KO_SugABC	-0.408	-0.611
H37Rv_KO_MbtN	-1.289	-1.208
Trans05	-1.862	-0.82
macrophage_unactivated	1.405	0.028
IL1	-0.641	0.199
Rapamycin	0.577	0.255
Tcell	0.495	0.218
GMCSF	-0.333	-0.483
IFNab	-0.248	0.275
IFNg	0.208	0.535
IFNg_GMCSF1	1.112	0.858
Rv1432_day32	0.0	-0.312
Rv1565c_day32	-0.381	0.0
secA2_input	-0.521	-0.534
delta_Rv3594	-1.75	0.02
delta_Rv3717	-0.941	0.352
delta_Rv3811	-1.029	-0.494
delta_Rv0954	0.129	0.376
PonA1	-0.799	0.347
EccD1_KO	0.0	-0.358
EspI_KO	0.55	-0.462
PE35_KO	0.0	-0.473
PPE68_KO	1.161	-0.416
glycerol2	-0.311	0.758
lignocerate	-1.161	0.0
oleate	0.213	0.693
phosphatidylcholine	-0.391	0.137
acetate	-1.297	-0.329
glucAc	-2.417	-0.151
Rv0950ko	0.0	0.103
Rv1096ko	1.65	0.235
Rv3684ko	1.536	0.327
delta_otsA_trehalose	-0.807	1.412