TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0502/-:

update plot	correlation	link to info on gene
Rv2185c/TB16.3	(cc=0.8023)	info on Rv2185c/TB16.3
Rv0501/galE2	(cc=0.7955)	info on Rv0501/galE2
Rv0642c/mmaA4	(cc=0.7774)	info on Rv0642c/mmaA4
Rv3050c/-	(cc=0.7399)	info on Rv3050c/-
Rv1780/-	(cc=0.7318)	info on Rv1780/-
Rv1058/fadD14	(cc=0.7215)	info on Rv1058/fadD14
Rv2184c/-	(cc=0.715)	info on Rv2184c/-
Rv1335/cysO	(cc=0.7142)	info on Rv1335/cysO
Rv2569c/-	(cc=0.7071)	info on Rv2569c/-
Rv0644c/mmaA2	(cc=0.7025)	info on Rv0644c/mmaA2

Correlation of Rv0502/- with Rv1780/-

Normalized LFCs for Rv0502/-:
(description and provenance of datasets)

	Rv0502/-	Rv1780/-
Fe_supp_jason_reseq	0.696	-1.778
low_pH_jason_reseq	1.318	-0.34
NO_jason_reseq	1.78	-2.084
B6_jason_reseq	-0.709	-3.549
MHCII_jason_reseq	0.086	-0.977
Isoniazid02	-0.332	2.506
Rifampicin4	0.623	-0.639
Ethambutol3	0.023	1.978
Meropenem3	0.289	0.727
Vancomycin16	-0.767	-0.491
Rv2680_day32	0.065	1.835
H37Rv_KO_MarP	0.608	-0.267
hypoxia_3wks	2.544	1.288
hypoxia_6wks	1.639	3.454
glycerol	1.066	2.188
cholesterol	0.715	2.714
AJ	0.904	-0.768
Bibs02	0.199	1.197
Bibs02c	0.059	1.17
BL6	1.258	1.216
BL6a	2.429	1.807
BXD01	2.883	2.028
BXD010	2.113	1.29
BXD011	2.075	3.362
BXD03	1.244	1.659
BXD04	2.334	2.619
BXD05	2.061	1.815
BXD06	2.32	3.056
BXD07	2.325	1.865
BXD08	1.898	1.959
BXD09	2.995	2.253
CAST	-0.771	-1.922
CCcont	2.029	0.954
DS01	0.489	0.435
DS02	0.55	-1.03
DS04	1.216	0.232
DS0c	0.823	0.74
GP01	1.933	2.552
GP02	1.699	2.909
GP0c	1.132	2.635
NOD	-0.236	-1.01
NZO	0.267	-0.123
PWK	-1.037	-1.451
H37Rv_KO_CtpC	0.198	1.377
H37Rv_KO_CtpD	1.721	-0.826
H37Rv_KO_Rv1272	2.664	1.908
H37Rv_KO_SugABC	1.635	2.077
H37Rv_KO_MbtN	2.769	3.96
Trans05	3.129	2.432
macrophage_unactivated	1.49	-0.189
IL1	-1.797	-1.264
Rapamycin	-0.166	-0.85
Tcell	1.411	2.444
GMCSF	-0.23	-1.009
IFNab	0.623	0.641
IFNg	-0.676	-1.732
IFNg_GMCSF1	-0.38	-3.126
Rv1432_day32	2.034	2.211
Rv1565c_day32	-1.219	1.35
secA2_input	-0.471	-1.45
delta_Rv3594	0.74	1.334
delta_Rv3717	1.886	2.956
delta_Rv3811	1.108	1.866
delta_Rv0954	-1.868	-1.335
PonA1	-1.487	-2.652
EccD1_KO	-1.075	-2.993
EspI_KO	-0.613	-2.21
PE35_KO	-1.654	-2.634
PPE68_KO	-1.494	-2.102
glycerol2	0.551	0.483
lignocerate	-0.111	0.36
oleate	0.801	0.034
phosphatidylcholine	-0.419	0.653
acetate	0.284	-0.374
glucAc	0.006	-0.518
Rv0950ko	-1.01	-2.783
Rv1096ko	-1.439	-3.685
Rv3684ko	-1.061	-2.731
delta_otsA_trehalose	-0.207	-1.034