TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0036c/-:

update plot	correlation	link to info on gene
Rv1992c/ctpG	(cc=0.5606)	info on Rv1992c/ctpG
Rv2831/echA16	(cc=0.5496)	info on Rv2831/echA16
Rv2811/-	(cc=0.5483)	info on Rv2811/-
Rv1839c/vapB13	(cc=0.522)	info on Rv1839c/vapB13
Rv0133/-	(cc=0.5195)	info on Rv0133/-
Rv1936/-	(cc=0.5057)	info on Rv1936/-
Rv1773c/-	(cc=0.5039)	info on Rv1773c/-
Rv2174/mptA	(cc=0.4965)	info on Rv2174/mptA
Rv2913c/-	(cc=0.4864)	info on Rv2913c/-
Rv2917/-	(cc=0.4797)	info on Rv2917/-

Correlation of Rv0036c/- with Rv2917/-

Normalized LFCs for Rv0036c/-:
(description and provenance of datasets)

	Rv0036c/-	Rv2917/-
Fe_supp_jason_reseq	-0.346	-0.085
low_pH_jason_reseq	-1.297	-0.395
NO_jason_reseq	0.202	-0.181
B6_jason_reseq	0.25	1.063
MHCII_jason_reseq	0.134	0.894
Isoniazid02	0.652	0.57
Rifampicin4	0.717	0.089
Ethambutol3	1.378	0.99
Meropenem3	0.537	1.087
Vancomycin16	0.873	0.231
Rv2680_day32	-3.314	-0.055
H37Rv_KO_MarP	0.148	0.051
hypoxia_3wks	0.463	0.323
hypoxia_6wks	-0.969	0.169
glycerol	1.205	0.623
cholesterol	0.106	0.27
AJ	0.304	0.061
Bibs02	0.229	0.49
Bibs02c	0.653	0.652
BL6	-1.378	-0.73
BL6a	-0.296	-0.009
BXD01	-1.055	-0.198
BXD010	-1.216	-1.009
BXD011	0.465	-0.867
BXD03	-1.212	-0.669
BXD04	-0.4	-0.998
BXD05	-0.13	-0.538
BXD06	-0.199	-0.516
BXD07	-0.133	-0.675
BXD08	-0.436	-0.558
BXD09	-0.657	-1.094
CAST	-0.901	0.496
CCcont	-1.863	-0.884
DS01	0.375	0.601
DS02	0.403	0.085
DS04	-0.18	0.928
DS0c	-0.38	0.338
GP01	1.587	0.068
GP02	0.505	0.161
GP0c	0.469	-0.041
NOD	-0.633	0.376
NZO	-0.22	0.273
PWK	0.47	0.618
H37Rv_KO_CtpC	-0.298	-0.166
H37Rv_KO_CtpD	-0.256	-0.952
H37Rv_KO_Rv1272	-0.716	0.148
H37Rv_KO_SugABC	0.088	0.876
H37Rv_KO_MbtN	0.111	-0.392
Trans05	0.164	-0.065
macrophage_unactivated	-0.3	-0.063
IL1	-0.599	-0.792
Rapamycin	0.681	0.061
Tcell	-1.111	-0.238
GMCSF	0.945	0.0
IFNab	0.033	-0.317
IFNg	-0.834	0.027
IFNg_GMCSF1	0.493	0.063
Rv1432_day32	0.379	0.112
Rv1565c_day32	0.479	-0.174
secA2_input	0.459	-0.501
delta_Rv3594	0.33	0.395
delta_Rv3717	0.886	0.792
delta_Rv3811	-0.159	0.327
delta_Rv0954	1.416	0.684
PonA1	0.263	0.854
EccD1_KO	-0.082	0.753
EspI_KO	-1.112	0.436
PE35_KO	0.365	0.123
PPE68_KO	0.49	0.202
glycerol2	-0.376	-0.091
lignocerate	-1.436	-0.387
oleate	-0.451	0.379
phosphatidylcholine	-0.784	0.16
acetate	-2.018	-0.416
glucAc	-2.881	-0.97
Rv0950ko	0.075	-0.163
Rv1096ko	-0.178	0.793
Rv3684ko	0.285	0.272
delta_otsA_trehalose	0.786	0.718