TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv0036c/-:

update plot	correlation	link to info on gene
Rv1992c/ctpG	(cc=0.5606)	info on Rv1992c/ctpG
Rv2831/echA16	(cc=0.5496)	info on Rv2831/echA16
Rv2811/-	(cc=0.5483)	info on Rv2811/-
Rv1839c/vapB13	(cc=0.522)	info on Rv1839c/vapB13
Rv0133/-	(cc=0.5195)	info on Rv0133/-
Rv1936/-	(cc=0.5057)	info on Rv1936/-
Rv1773c/-	(cc=0.5039)	info on Rv1773c/-
Rv2174/mptA	(cc=0.4965)	info on Rv2174/mptA
Rv2913c/-	(cc=0.4864)	info on Rv2913c/-
Rv2917/-	(cc=0.4797)	info on Rv2917/-

Correlation of Rv0036c/- with Rv0133/-

Normalized LFCs for Rv0036c/-:
(description and provenance of datasets)

	Rv0036c/-	Rv0133/-
Fe_supp_jason_reseq	-0.346	-0.493
low_pH_jason_reseq	-1.297	-1.347
NO_jason_reseq	0.202	0.186
B6_jason_reseq	0.25	-0.893
MHCII_jason_reseq	0.134	-0.131
Isoniazid02	0.652	0.079
Rifampicin4	0.717	0.271
Ethambutol3	1.378	0.106
Meropenem3	0.537	0.049
Vancomycin16	0.873	0.019
Rv2680_day32	-3.314	-2.344
H37Rv_KO_MarP	0.148	0.025
hypoxia_3wks	0.463	-0.167
hypoxia_6wks	-0.969	-0.495
glycerol	1.205	0.309
cholesterol	0.106	0.255
AJ	0.304	0.269
Bibs02	0.229	-0.683
Bibs02c	0.653	-0.203
BL6	-1.378	-0.925
BL6a	-0.296	-0.641
BXD01	-1.055	-0.334
BXD010	-1.216	-0.618
BXD011	0.465	-0.919
BXD03	-1.212	0.102
BXD04	-0.4	-1.277
BXD05	-0.13	-1.169
BXD06	-0.199	-1.062
BXD07	-0.133	-0.749
BXD08	-0.436	-1.405
BXD09	-0.657	-0.753
CAST	-0.901	-0.47
CCcont	-1.863	-2.318
DS01	0.375	-0.293
DS02	0.403	-0.978
DS04	-0.18	0.069
DS0c	-0.38	-0.729
GP01	1.587	-0.395
GP02	0.505	0.048
GP0c	0.469	-0.192
NOD	-0.633	-1.01
NZO	-0.22	0.361
PWK	0.47	-0.065
H37Rv_KO_CtpC	-0.298	-0.76
H37Rv_KO_CtpD	-0.256	0.702
H37Rv_KO_Rv1272	-0.716	-0.742
H37Rv_KO_SugABC	0.088	0.621
H37Rv_KO_MbtN	0.111	-1.933
Trans05	0.164	-0.844
macrophage_unactivated	-0.3	-0.963
IL1	-0.599	-1.183
Rapamycin	0.681	-0.862
Tcell	-1.111	-0.834
GMCSF	0.945	-0.351
IFNab	0.033	-0.922
IFNg	-0.834	-0.053
IFNg_GMCSF1	0.493	1.405
Rv1432_day32	0.379	0.112
Rv1565c_day32	0.479	-0.126
secA2_input	0.459	0.437
delta_Rv3594	0.33	-0.13
delta_Rv3717	0.886	-0.045
delta_Rv3811	-0.159	0.0
delta_Rv0954	1.416	0.634
PonA1	0.263	0.997
EccD1_KO	-0.082	-0.069
EspI_KO	-1.112	-0.242
PE35_KO	0.365	-1.205
PPE68_KO	0.49	-1.389
glycerol2	-0.376	-1.709
lignocerate	-1.436	-0.971
oleate	-0.451	-0.371
phosphatidylcholine	-0.784	-1.203
acetate	-2.018	0.012
glucAc	-2.881	-1.935
Rv0950ko	0.075	0.229
Rv1096ko	-0.178	0.823
Rv3684ko	0.285	0.167
delta_otsA_trehalose	0.786	0.906