TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3181c/-:

update plot	correlation	link to info on gene
Rv3112/moaD1	(cc=0.4832)	info on Rv3112/moaD1
Rv2350c/plcB	(cc=0.4687)	info on Rv2350c/plcB
Rv2899c/fdhD	(cc=0.4679)	info on Rv2899c/fdhD
Rv2134c/-	(cc=0.4426)	info on Rv2134c/-
Rv2274c/mazF8	(cc=0.4248)	info on Rv2274c/mazF8
Rv1058/fadD14	(cc=0.4247)	info on Rv1058/fadD14
Rv0502/-	(cc=0.4207)	info on Rv0502/-
Rv2668/-	(cc=0.4201)	info on Rv2668/-
Rv1529/fadD24	(cc=0.4188)	info on Rv1529/fadD24
Rv1913/-	(cc=0.4134)	info on Rv1913/-

Correlation of Rv3181c/- with Rv2350c/plcB

Normalized LFCs for Rv3181c/-:
(description and provenance of datasets)

	Rv3181c/-	Rv2350c/plcB
Fe_supp_jason_reseq	-1.492	0.153
low_pH_jason_reseq	0.771	-0.32
NO_jason_reseq	1.452	-0.116
B6_jason_reseq	-3.268	-0.249
MHCII_jason_reseq	-1.586	-0.936
Isoniazid02	-1.368	-0.953
Rifampicin4	1.66	-0.022
Ethambutol3	-0.581	0.525
Meropenem3	-0.724	-0.677
Vancomycin16	-0.377	-0.501
Rv2680_day32	0.0	0.171
H37Rv_KO_MarP	0.195	0.286
hypoxia_3wks	2.484	2.285
hypoxia_6wks	2.754	2.076
glycerol	-0.521	-0.12
cholesterol	-0.435	0.923
AJ	2.689	0.445
Bibs02	-0.188	0.579
Bibs02c	-1.657	-0.38
BL6	0.0	0.747
BL6a	0.514	0.951
BXD01	2.382	0.845
BXD010	-0.928	1.313
BXD011	0.08	0.691
BXD03	1.596	1.102
BXD04	2.056	1.076
BXD05	0.861	1.051
BXD06	2.018	0.598
BXD07	1.154	0.931
BXD08	0.941	0.805
BXD09	1.84	0.694
CAST	-1.014	0.098
CCcont	1.411	0.588
DS01	0.075	-0.31
DS02	-1.438	-0.739
DS04	3.172	0.736
DS0c	1.056	-0.376
GP01	2.088	0.581
GP02	-0.056	-0.13
GP0c	0.494	0.257
NOD	0.747	1.66
NZO	0.663	0.153
PWK	0.124	0.364
H37Rv_KO_CtpC	0.724	0.853
H37Rv_KO_CtpD	1.369	1.379
H37Rv_KO_Rv1272	-0.424	0.921
H37Rv_KO_SugABC	-0.215	0.438
H37Rv_KO_MbtN	-0.62	0.495
Trans05	-0.134	1.562
macrophage_unactivated	1.938	0.041
IL1	0.086	0.454
Rapamycin	-0.279	0.021
Tcell	3.539	0.596
GMCSF	-1.624	-0.09
IFNab	-2.289	-0.103
IFNg	-1.408	0.358
IFNg_GMCSF1	-2.077	0.041
Rv1432_day32	-1.544	0.576
Rv1565c_day32	-0.218	-0.115
secA2_input	0.617	0.102
delta_Rv3594	1.066	0.225
delta_Rv3717	0.393	0.104
delta_Rv3811	1.081	0.677
delta_Rv0954	1.124	0.107
PonA1	-1.773	0.053
EccD1_KO	0.697	-0.408
EspI_KO	-0.838	-0.317
PE35_KO	-0.228	-0.458
PPE68_KO	0.678	-0.355
glycerol2	0.402	0.465
lignocerate	0.666	0.057
oleate	-0.163	0.435
phosphatidylcholine	0.508	0.29
acetate	-0.053	-0.186
glucAc	0.473	-0.038
Rv0950ko	-0.808	0.371
Rv1096ko	-1.336	-0.467
Rv3684ko	-0.567	0.386
delta_otsA_trehalose	1.574	0.081