TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3181c/-:

update plot	correlation	link to info on gene
Rv3112/moaD1	(cc=0.4832)	info on Rv3112/moaD1
Rv2350c/plcB	(cc=0.4687)	info on Rv2350c/plcB
Rv2899c/fdhD	(cc=0.4679)	info on Rv2899c/fdhD
Rv2134c/-	(cc=0.4426)	info on Rv2134c/-
Rv2274c/mazF8	(cc=0.4248)	info on Rv2274c/mazF8
Rv1058/fadD14	(cc=0.4247)	info on Rv1058/fadD14
Rv0502/-	(cc=0.4207)	info on Rv0502/-
Rv2668/-	(cc=0.4201)	info on Rv2668/-
Rv1529/fadD24	(cc=0.4188)	info on Rv1529/fadD24
Rv1913/-	(cc=0.4134)	info on Rv1913/-

Correlation of Rv3181c/- with Rv0502/-

Normalized LFCs for Rv3181c/-:
(description and provenance of datasets)

	Rv3181c/-	Rv0502/-
Fe_supp_jason_reseq	-1.492	0.696
low_pH_jason_reseq	0.771	1.318
NO_jason_reseq	1.452	1.78
B6_jason_reseq	-3.268	-0.709
MHCII_jason_reseq	-1.586	0.086
Isoniazid02	-1.368	-0.332
Rifampicin4	1.66	0.623
Ethambutol3	-0.581	0.023
Meropenem3	-0.724	0.289
Vancomycin16	-0.377	-0.767
Rv2680_day32	0.0	0.065
H37Rv_KO_MarP	0.195	0.608
hypoxia_3wks	2.484	2.544
hypoxia_6wks	2.754	1.639
glycerol	-0.521	1.066
cholesterol	-0.435	0.715
AJ	2.689	0.904
Bibs02	-0.188	0.199
Bibs02c	-1.657	0.059
BL6	0.0	1.258
BL6a	0.514	2.429
BXD01	2.382	2.883
BXD010	-0.928	2.113
BXD011	0.08	2.075
BXD03	1.596	1.244
BXD04	2.056	2.334
BXD05	0.861	2.061
BXD06	2.018	2.32
BXD07	1.154	2.325
BXD08	0.941	1.898
BXD09	1.84	2.995
CAST	-1.014	-0.771
CCcont	1.411	2.029
DS01	0.075	0.489
DS02	-1.438	0.55
DS04	3.172	1.216
DS0c	1.056	0.823
GP01	2.088	1.933
GP02	-0.056	1.699
GP0c	0.494	1.132
NOD	0.747	-0.236
NZO	0.663	0.267
PWK	0.124	-1.037
H37Rv_KO_CtpC	0.724	0.198
H37Rv_KO_CtpD	1.369	1.721
H37Rv_KO_Rv1272	-0.424	2.664
H37Rv_KO_SugABC	-0.215	1.635
H37Rv_KO_MbtN	-0.62	2.769
Trans05	-0.134	3.129
macrophage_unactivated	1.938	1.49
IL1	0.086	-1.797
Rapamycin	-0.279	-0.166
Tcell	3.539	1.411
GMCSF	-1.624	-0.23
IFNab	-2.289	0.623
IFNg	-1.408	-0.676
IFNg_GMCSF1	-2.077	-0.38
Rv1432_day32	-1.544	2.034
Rv1565c_day32	-0.218	-1.219
secA2_input	0.617	-0.471
delta_Rv3594	1.066	0.74
delta_Rv3717	0.393	1.886
delta_Rv3811	1.081	1.108
delta_Rv0954	1.124	-1.868
PonA1	-1.773	-1.487
EccD1_KO	0.697	-1.075
EspI_KO	-0.838	-0.613
PE35_KO	-0.228	-1.654
PPE68_KO	0.678	-1.494
glycerol2	0.402	0.551
lignocerate	0.666	-0.111
oleate	-0.163	0.801
phosphatidylcholine	0.508	-0.419
acetate	-0.053	0.284
glucAc	0.473	0.006
Rv0950ko	-0.808	-1.01
Rv1096ko	-1.336	-1.439
Rv3684ko	-0.567	-1.061
delta_otsA_trehalose	1.574	-0.207