TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3181c/-:

update plot	correlation	link to info on gene
Rv3112/moaD1	(cc=0.4832)	info on Rv3112/moaD1
Rv2350c/plcB	(cc=0.4687)	info on Rv2350c/plcB
Rv2899c/fdhD	(cc=0.4679)	info on Rv2899c/fdhD
Rv2134c/-	(cc=0.4426)	info on Rv2134c/-
Rv2274c/mazF8	(cc=0.4248)	info on Rv2274c/mazF8
Rv1058/fadD14	(cc=0.4247)	info on Rv1058/fadD14
Rv0502/-	(cc=0.4207)	info on Rv0502/-
Rv2668/-	(cc=0.4201)	info on Rv2668/-
Rv1529/fadD24	(cc=0.4188)	info on Rv1529/fadD24
Rv1913/-	(cc=0.4134)	info on Rv1913/-

Correlation of Rv3181c/- with Rv1058/fadD14

Normalized LFCs for Rv3181c/-:
(description and provenance of datasets)

	Rv3181c/-	Rv1058/fadD14
Fe_supp_jason_reseq	-1.492	0.845
low_pH_jason_reseq	0.771	2.618
NO_jason_reseq	1.452	-0.323
B6_jason_reseq	-3.268	-1.356
MHCII_jason_reseq	-1.586	-0.435
Isoniazid02	-1.368	-0.194
Rifampicin4	1.66	-0.116
Ethambutol3	-0.581	0.148
Meropenem3	-0.724	0.406
Vancomycin16	-0.377	-0.544
Rv2680_day32	0.0	1.435
H37Rv_KO_MarP	0.195	-0.653
hypoxia_3wks	2.484	1.535
hypoxia_6wks	2.754	3.247
glycerol	-0.521	1.09
cholesterol	-0.435	1.217
AJ	2.689	1.03
Bibs02	-0.188	0.262
Bibs02c	-1.657	1.816
BL6	0.0	3.092
BL6a	0.514	2.987
BXD01	2.382	3.11
BXD010	-0.928	2.481
BXD011	0.08	2.298
BXD03	1.596	1.948
BXD04	2.056	2.976
BXD05	0.861	2.087
BXD06	2.018	2.618
BXD07	1.154	2.642
BXD08	0.941	2.699
BXD09	1.84	2.228
CAST	-1.014	-0.222
CCcont	1.411	2.164
DS01	0.075	0.14
DS02	-1.438	0.83
DS04	3.172	0.975
DS0c	1.056	0.963
GP01	2.088	2.962
GP02	-0.056	2.733
GP0c	0.494	2.85
NOD	0.747	0.997
NZO	0.663	0.675
PWK	0.124	0.281
H37Rv_KO_CtpC	0.724	0.877
H37Rv_KO_CtpD	1.369	1.601
H37Rv_KO_Rv1272	-0.424	2.677
H37Rv_KO_SugABC	-0.215	3.098
H37Rv_KO_MbtN	-0.62	1.92
Trans05	-0.134	2.268
macrophage_unactivated	1.938	-0.123
IL1	0.086	-0.116
Rapamycin	-0.279	-0.371
Tcell	3.539	0.394
GMCSF	-1.624	-1.714
IFNab	-2.289	0.284
IFNg	-1.408	-2.913
IFNg_GMCSF1	-2.077	-2.599
Rv1432_day32	-1.544	2.88
Rv1565c_day32	-0.218	1.579
secA2_input	0.617	1.374
delta_Rv3594	1.066	1.779
delta_Rv3717	0.393	2.157
delta_Rv3811	1.081	1.756
delta_Rv0954	1.124	0.049
PonA1	-1.773	-0.851
EccD1_KO	0.697	-0.046
EspI_KO	-0.838	-0.365
PE35_KO	-0.228	-0.98
PPE68_KO	0.678	-0.41
glycerol2	0.402	1.219
lignocerate	0.666	1.649
oleate	-0.163	-1.157
phosphatidylcholine	0.508	0.655
acetate	-0.053	0.712
glucAc	0.473	0.682
Rv0950ko	-0.808	-0.648
Rv1096ko	-1.336	0.1
Rv3684ko	-0.567	-0.262
delta_otsA_trehalose	1.574	-0.009