TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv3181c/-:

update plot	correlation	link to info on gene
Rv3112/moaD1	(cc=0.4832)	info on Rv3112/moaD1
Rv2350c/plcB	(cc=0.4687)	info on Rv2350c/plcB
Rv2899c/fdhD	(cc=0.4679)	info on Rv2899c/fdhD
Rv2134c/-	(cc=0.4426)	info on Rv2134c/-
Rv2274c/mazF8	(cc=0.4248)	info on Rv2274c/mazF8
Rv1058/fadD14	(cc=0.4247)	info on Rv1058/fadD14
Rv0502/-	(cc=0.4207)	info on Rv0502/-
Rv2668/-	(cc=0.4201)	info on Rv2668/-
Rv1529/fadD24	(cc=0.4188)	info on Rv1529/fadD24
Rv1913/-	(cc=0.4134)	info on Rv1913/-

Correlation of Rv3181c/- with Rv1529/fadD24

Normalized LFCs for Rv3181c/-:
(description and provenance of datasets)

	Rv3181c/-	Rv1529/fadD24
Fe_supp_jason_reseq	-1.492	-0.196
low_pH_jason_reseq	0.771	0.463
NO_jason_reseq	1.452	0.045
B6_jason_reseq	-3.268	-0.222
MHCII_jason_reseq	-1.586	-0.033
Isoniazid02	-1.368	-0.233
Rifampicin4	1.66	-0.103
Ethambutol3	-0.581	-0.275
Meropenem3	-0.724	-0.117
Vancomycin16	-0.377	-0.207
Rv2680_day32	0.0	-0.571
H37Rv_KO_MarP	0.195	-0.183
hypoxia_3wks	2.484	0.128
hypoxia_6wks	2.754	0.033
glycerol	-0.521	0.282
cholesterol	-0.435	0.0
AJ	2.689	0.55
Bibs02	-0.188	0.03
Bibs02c	-1.657	0.411
BL6	0.0	0.655
BL6a	0.514	0.571
BXD01	2.382	0.656
BXD010	-0.928	0.684
BXD011	0.08	0.43
BXD03	1.596	0.265
BXD04	2.056	0.531
BXD05	0.861	0.168
BXD06	2.018	0.528
BXD07	1.154	0.309
BXD08	0.941	0.261
BXD09	1.84	0.765
CAST	-1.014	0.484
CCcont	1.411	0.705
DS01	0.075	0.559
DS02	-1.438	0.0
DS04	3.172	0.485
DS0c	1.056	-0.616
GP01	2.088	1.106
GP02	-0.056	0.32
GP0c	0.494	0.573
NOD	0.747	0.703
NZO	0.663	0.857
PWK	0.124	-0.394
H37Rv_KO_CtpC	0.724	1.021
H37Rv_KO_CtpD	1.369	0.969
H37Rv_KO_Rv1272	-0.424	0.781
H37Rv_KO_SugABC	-0.215	1.559
H37Rv_KO_MbtN	-0.62	0.217
Trans05	-0.134	0.456
macrophage_unactivated	1.938	0.473
IL1	0.086	-0.303
Rapamycin	-0.279	0.35
Tcell	3.539	0.43
GMCSF	-1.624	-0.747
IFNab	-2.289	-0.505
IFNg	-1.408	-0.569
IFNg_GMCSF1	-2.077	-0.063
Rv1432_day32	-1.544	-0.999
Rv1565c_day32	-0.218	0.25
secA2_input	0.617	-1.212
delta_Rv3594	1.066	0.295
delta_Rv3717	0.393	-0.097
delta_Rv3811	1.081	0.055
delta_Rv0954	1.124	1.018
PonA1	-1.773	0.043
EccD1_KO	0.697	-0.25
EspI_KO	-0.838	0.125
PE35_KO	-0.228	0.169
PPE68_KO	0.678	0.624
glycerol2	0.402	0.195
lignocerate	0.666	0.132
oleate	-0.163	0.078
phosphatidylcholine	0.508	0.332
acetate	-0.053	-0.296
glucAc	0.473	0.132
Rv0950ko	-0.808	0.112
Rv1096ko	-1.336	-0.609
Rv3684ko	-0.567	-1.002
delta_otsA_trehalose	1.574	0.677