TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2983/-:

update plot	correlation	link to info on gene
Rv3262/fbiB	(cc=0.7653)	info on Rv3262/fbiB
Rv1173/fbiC	(cc=0.745)	info on Rv1173/fbiC
Rv3624c/hpt	(cc=0.7214)	info on Rv3624c/hpt
Rv1324/-	(cc=0.7073)	info on Rv1324/-
Rv0860/fadB	(cc=0.6573)	info on Rv0860/fadB
Rv3228/-	(cc=0.63)	info on Rv3228/-
Rv2909c/rpsP	(cc=0.6228)	info on Rv2909c/rpsP
Rv0526/-	(cc=0.6198)	info on Rv0526/-
Rv3261/fbiA	(cc=0.6164)	info on Rv3261/fbiA
Rv1170/mshB	(cc=0.5863)	info on Rv1170/mshB

Correlation of Rv2983/- with Rv1173/fbiC

Normalized LFCs for Rv2983/-:
(description and provenance of datasets)

	Rv2983/-	Rv1173/fbiC
Fe_supp_jason_reseq	0.218	0.8
low_pH_jason_reseq	0.0	0.124
NO_jason_reseq	0.0	-0.42
B6_jason_reseq	0.292	0.16
MHCII_jason_reseq	0.135	0.27
Isoniazid02	2.89	2.424
Rifampicin4	2.142	0.931
Ethambutol3	1.249	1.147
Meropenem3	0.189	1.23
Vancomycin16	2.183	0.546
Rv2680_day32	0.0	-1.189
H37Rv_KO_MarP	1.112	-0.412
hypoxia_3wks	-0.502	-0.478
hypoxia_6wks	-0.549	-1.539
glycerol	0.856	1.128
cholesterol	1.504	0.583
AJ	0.232	0.513
Bibs02	0.0	0.0
Bibs02c	0.209	0.355
BL6	0.0	-0.456
BL6a	0.0	0.336
BXD01	0.0	0.151
BXD010	0.0	-0.168
BXD011	0.0	-0.167
BXD03	0.0	0.08
BXD04	0.0	-0.347
BXD05	0.135	-0.176
BXD06	0.133	0.155
BXD07	0.0	0.373
BXD08	0.0	-0.485
BXD09	0.0	0.163
CAST	0.0	-0.302
CCcont	1.082	1.832
DS01	1.947	1.783
DS02	0.0	1.134
DS04	0.194	1.834
DS0c	0.596	1.287
GP01	0.0	-0.548
GP02	0.0	-0.462
GP0c	0.0	-0.591
NOD	0.0	-0.295
NZO	0.0	-0.262
PWK	0.0	-0.398
H37Rv_KO_CtpC	0.0	0.785
H37Rv_KO_CtpD	0.127	1.374
H37Rv_KO_Rv1272	0.0	0.445
H37Rv_KO_SugABC	0.099	0.168
H37Rv_KO_MbtN	0.0	0.866
Trans05	0.0	0.631
macrophage_unactivated	0.0	0.783
IL1	0.0	0.258
Rapamycin	0.0	0.0
Tcell	0.0	0.554
GMCSF	0.0	1.035
IFNab	0.0	0.0
IFNg	0.0	-0.516
IFNg_GMCSF1	0.0	0.534
Rv1432_day32	0.0	-0.164
Rv1565c_day32	0.0	0.986
secA2_input	-0.485	-1.154
delta_Rv3594	1.811	0.422
delta_Rv3717	0.0	-1.688
delta_Rv3811	0.934	0.457
delta_Rv0954	0.811	1.388
PonA1	1.367	0.919
EccD1_KO	-0.664	-1.273
EspI_KO	-1.243	-0.516
PE35_KO	1.52	1.508
PPE68_KO	1.667	0.595
glycerol2	-1.297	-1.645
lignocerate	-2.345	-3.039
oleate	-2.358	-2.915
phosphatidylcholine	-2.697	-3.808
acetate	-1.102	0.203
glucAc	-1.49	-0.246
Rv0950ko	-1.294	-0.546
Rv1096ko	-0.256	-1.034
Rv3684ko	-0.727	-1.055
delta_otsA_trehalose	-0.111	0.414