TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2970c/lipN:

update plot	correlation	link to info on gene
Rv0413/mutT3	(cc=0.4756)	info on Rv0413/mutT3
Rv1624c/-	(cc=0.4444)	info on Rv1624c/-
Rv0804/-	(cc=0.4391)	info on Rv0804/-
Rv0925c/-	(cc=0.4232)	info on Rv0925c/-
Rv3237c/-	(cc=0.4087)	info on Rv3237c/-
Rv3406/-	(cc=0.4014)	info on Rv3406/-
Rv2675c/-	(cc=0.3931)	info on Rv2675c/-
Rv3329/-	(cc=0.3869)	info on Rv3329/-
Rv2061c/-	(cc=0.3855)	info on Rv2061c/-
Rv0131c/fadE1	(cc=0.3782)	info on Rv0131c/fadE1

Correlation of Rv2970c/lipN with Rv3406/-

Normalized LFCs for Rv2970c/lipN:
(description and provenance of datasets)

	Rv2970c/lipN	Rv3406/-
Fe_supp_jason_reseq	0.0	-0.343
low_pH_jason_reseq	0.507	-0.477
NO_jason_reseq	-0.585	-0.347
B6_jason_reseq	0.671	-0.298
MHCII_jason_reseq	0.326	0.298
Isoniazid02	-1.244	-1.986
Rifampicin4	-0.236	0.368
Ethambutol3	-0.251	-1.893
Meropenem3	-0.286	-0.167
Vancomycin16	-0.098	-0.748
Rv2680_day32	0.781	-0.062
H37Rv_KO_MarP	0.466	0.524
hypoxia_3wks	-0.359	-0.032
hypoxia_6wks	0.81	-0.386
glycerol	0.658	0.023
cholesterol	-0.073	-0.246
AJ	0.156	0.531
Bibs02	0.233	0.201
Bibs02c	-0.106	-0.662
BL6	0.449	1.034
BL6a	0.296	0.145
BXD01	0.512	-0.008
BXD010	0.292	0.811
BXD011	0.698	0.153
BXD03	0.23	-0.158
BXD04	0.41	0.425
BXD05	0.435	0.565
BXD06	0.671	0.274
BXD07	1.091	0.336
BXD08	0.25	0.023
BXD09	0.63	0.494
CAST	0.432	0.46
CCcont	-0.089	0.043
DS01	-0.299	0.31
DS02	-0.369	-0.05
DS04	0.008	0.077
DS0c	-0.325	-0.239
GP01	0.624	0.288
GP02	-0.064	1.221
GP0c	-0.424	-0.528
NOD	-0.223	0.809
NZO	-0.572	-0.194
PWK	0.435	0.512
H37Rv_KO_CtpC	-0.315	-0.067
H37Rv_KO_CtpD	-0.427	0.795
H37Rv_KO_Rv1272	0.481	-0.911
H37Rv_KO_SugABC	0.172	0.155
H37Rv_KO_MbtN	0.239	-0.211
Trans05	0.506	-0.565
macrophage_unactivated	-0.139	-0.331
IL1	0.715	0.039
Rapamycin	0.519	-0.04
Tcell	0.525	0.124
GMCSF	0.201	0.195
IFNab	0.145	-0.218
IFNg	0.612	0.449
IFNg_GMCSF1	0.518	0.251
Rv1432_day32	0.837	0.252
Rv1565c_day32	0.25	-0.24
secA2_input	0.676	-0.016
delta_Rv3594	-1.256	-0.465
delta_Rv3717	-0.531	-0.262
delta_Rv3811	-0.198	-0.149
delta_Rv0954	-0.57	0.419
PonA1	0.344	0.259
EccD1_KO	0.536	0.691
EspI_KO	0.465	0.046
PE35_KO	0.475	-0.047
PPE68_KO	0.093	-0.211
glycerol2	0.395	0.553
lignocerate	0.583	0.225
oleate	1.365	0.527
phosphatidylcholine	0.59	0.5
acetate	-0.559	0.219
glucAc	-0.308	0.06
Rv0950ko	0.718	0.573
Rv1096ko	1.004	0.694
Rv3684ko	0.282	0.151
delta_otsA_trehalose	0.676	1.329