TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2970c/lipN:

update plot	correlation	link to info on gene
Rv0413/mutT3	(cc=0.4756)	info on Rv0413/mutT3
Rv1624c/-	(cc=0.4444)	info on Rv1624c/-
Rv0804/-	(cc=0.4391)	info on Rv0804/-
Rv0925c/-	(cc=0.4232)	info on Rv0925c/-
Rv3237c/-	(cc=0.4087)	info on Rv3237c/-
Rv3406/-	(cc=0.4014)	info on Rv3406/-
Rv2675c/-	(cc=0.3931)	info on Rv2675c/-
Rv3329/-	(cc=0.3869)	info on Rv3329/-
Rv2061c/-	(cc=0.3855)	info on Rv2061c/-
Rv0131c/fadE1	(cc=0.3782)	info on Rv0131c/fadE1

Correlation of Rv2970c/lipN with Rv2675c/-

Normalized LFCs for Rv2970c/lipN:
(description and provenance of datasets)

	Rv2970c/lipN	Rv2675c/-
Fe_supp_jason_reseq	0.0	-0.175
low_pH_jason_reseq	0.507	-1.365
NO_jason_reseq	-0.585	-0.328
B6_jason_reseq	0.671	0.019
MHCII_jason_reseq	0.326	0.626
Isoniazid02	-1.244	-1.043
Rifampicin4	-0.236	-0.225
Ethambutol3	-0.251	-0.699
Meropenem3	-0.286	-1.433
Vancomycin16	-0.098	-1.082
Rv2680_day32	0.781	0.135
H37Rv_KO_MarP	0.466	0.024
hypoxia_3wks	-0.359	0.171
hypoxia_6wks	0.81	1.038
glycerol	0.658	0.443
cholesterol	-0.073	-0.016
AJ	0.156	-0.361
Bibs02	0.233	-0.029
Bibs02c	-0.106	0.023
BL6	0.449	0.213
BL6a	0.296	0.278
BXD01	0.512	0.092
BXD010	0.292	-0.175
BXD011	0.698	0.054
BXD03	0.23	-0.113
BXD04	0.41	0.284
BXD05	0.435	0.426
BXD06	0.671	0.275
BXD07	1.091	0.27
BXD08	0.25	0.052
BXD09	0.63	0.177
CAST	0.432	0.207
CCcont	-0.089	0.067
DS01	-0.299	0.241
DS02	-0.369	0.269
DS04	0.008	0.015
DS0c	-0.325	0.168
GP01	0.624	-0.24
GP02	-0.064	0.066
GP0c	-0.424	-0.004
NOD	-0.223	0.397
NZO	-0.572	-0.237
PWK	0.435	-0.053
H37Rv_KO_CtpC	-0.315	-0.32
H37Rv_KO_CtpD	-0.427	-0.578
H37Rv_KO_Rv1272	0.481	0.284
H37Rv_KO_SugABC	0.172	0.62
H37Rv_KO_MbtN	0.239	-0.47
Trans05	0.506	0.202
macrophage_unactivated	-0.139	-0.104
IL1	0.715	-0.098
Rapamycin	0.519	-0.11
Tcell	0.525	-0.117
GMCSF	0.201	0.597
IFNab	0.145	-0.091
IFNg	0.612	0.35
IFNg_GMCSF1	0.518	0.277
Rv1432_day32	0.837	0.108
Rv1565c_day32	0.25	-0.032
secA2_input	0.676	-0.177
delta_Rv3594	-1.256	0.251
delta_Rv3717	-0.531	-0.103
delta_Rv3811	-0.198	-0.406
delta_Rv0954	-0.57	-0.337
PonA1	0.344	0.121
EccD1_KO	0.536	0.266
EspI_KO	0.465	0.528
PE35_KO	0.475	0.163
PPE68_KO	0.093	0.032
glycerol2	0.395	0.657
lignocerate	0.583	0.979
oleate	1.365	0.464
phosphatidylcholine	0.59	0.819
acetate	-0.559	0.233
glucAc	-0.308	0.485
Rv0950ko	0.718	0.887
Rv1096ko	1.004	0.124
Rv3684ko	0.282	0.737
delta_otsA_trehalose	0.676	0.353