TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2970c/lipN:

update plot	correlation	link to info on gene
Rv0413/mutT3	(cc=0.4756)	info on Rv0413/mutT3
Rv1624c/-	(cc=0.4444)	info on Rv1624c/-
Rv0804/-	(cc=0.4391)	info on Rv0804/-
Rv0925c/-	(cc=0.4232)	info on Rv0925c/-
Rv3237c/-	(cc=0.4087)	info on Rv3237c/-
Rv3406/-	(cc=0.4014)	info on Rv3406/-
Rv2675c/-	(cc=0.3931)	info on Rv2675c/-
Rv3329/-	(cc=0.3869)	info on Rv3329/-
Rv2061c/-	(cc=0.3855)	info on Rv2061c/-
Rv0131c/fadE1	(cc=0.3782)	info on Rv0131c/fadE1

Correlation of Rv2970c/lipN with Rv3329/-

Normalized LFCs for Rv2970c/lipN:
(description and provenance of datasets)

	Rv2970c/lipN	Rv3329/-
Fe_supp_jason_reseq	0.0	0.0
low_pH_jason_reseq	0.507	0.33
NO_jason_reseq	-0.585	0.257
B6_jason_reseq	0.671	0.714
MHCII_jason_reseq	0.326	0.049
Isoniazid02	-1.244	-2.423
Rifampicin4	-0.236	0.598
Ethambutol3	-0.251	-1.639
Meropenem3	-0.286	-2.211
Vancomycin16	-0.098	-0.947
Rv2680_day32	0.781	-0.046
H37Rv_KO_MarP	0.466	-0.354
hypoxia_3wks	-0.359	0.323
hypoxia_6wks	0.81	0.418
glycerol	0.658	0.294
cholesterol	-0.073	0.128
AJ	0.156	0.576
Bibs02	0.233	0.114
Bibs02c	-0.106	-0.471
BL6	0.449	-0.095
BL6a	0.296	-0.357
BXD01	0.512	0.024
BXD010	0.292	-0.183
BXD011	0.698	-0.136
BXD03	0.23	0.412
BXD04	0.41	-0.07
BXD05	0.435	0.47
BXD06	0.671	-0.013
BXD07	1.091	0.197
BXD08	0.25	0.321
BXD09	0.63	-0.079
CAST	0.432	0.28
CCcont	-0.089	-0.159
DS01	-0.299	0.137
DS02	-0.369	0.444
DS04	0.008	0.035
DS0c	-0.325	0.079
GP01	0.624	0.022
GP02	-0.064	-0.011
GP0c	-0.424	-0.716
NOD	-0.223	-0.063
NZO	-0.572	0.656
PWK	0.435	0.459
H37Rv_KO_CtpC	-0.315	-0.471
H37Rv_KO_CtpD	-0.427	-0.278
H37Rv_KO_Rv1272	0.481	-0.856
H37Rv_KO_SugABC	0.172	-0.375
H37Rv_KO_MbtN	0.239	-0.939
Trans05	0.506	-0.265
macrophage_unactivated	-0.139	-0.281
IL1	0.715	0.098
Rapamycin	0.519	0.199
Tcell	0.525	-0.042
GMCSF	0.201	0.069
IFNab	0.145	-0.375
IFNg	0.612	0.088
IFNg_GMCSF1	0.518	0.041
Rv1432_day32	0.837	-0.288
Rv1565c_day32	0.25	0.627
secA2_input	0.676	0.343
delta_Rv3594	-1.256	-0.314
delta_Rv3717	-0.531	-0.258
delta_Rv3811	-0.198	-0.421
delta_Rv0954	-0.57	0.094
PonA1	0.344	0.264
EccD1_KO	0.536	-0.428
EspI_KO	0.465	0.1
PE35_KO	0.475	-0.7
PPE68_KO	0.093	-0.115
glycerol2	0.395	0.113
lignocerate	0.583	0.244
oleate	1.365	0.658
phosphatidylcholine	0.59	0.314
acetate	-0.559	-0.07
glucAc	-0.308	-0.458
Rv0950ko	0.718	0.054
Rv1096ko	1.004	0.262
Rv3684ko	0.282	-0.118
delta_otsA_trehalose	0.676	0.232