TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2970c/lipN:

update plot	correlation	link to info on gene
Rv0413/mutT3	(cc=0.4756)	info on Rv0413/mutT3
Rv1624c/-	(cc=0.4444)	info on Rv1624c/-
Rv0804/-	(cc=0.4391)	info on Rv0804/-
Rv0925c/-	(cc=0.4232)	info on Rv0925c/-
Rv3237c/-	(cc=0.4087)	info on Rv3237c/-
Rv3406/-	(cc=0.4014)	info on Rv3406/-
Rv2675c/-	(cc=0.3931)	info on Rv2675c/-
Rv3329/-	(cc=0.3869)	info on Rv3329/-
Rv2061c/-	(cc=0.3855)	info on Rv2061c/-
Rv0131c/fadE1	(cc=0.3782)	info on Rv0131c/fadE1

Correlation of Rv2970c/lipN with Rv0925c/-

Normalized LFCs for Rv2970c/lipN:
(description and provenance of datasets)

	Rv2970c/lipN	Rv0925c/-
Fe_supp_jason_reseq	0.0	-0.339
low_pH_jason_reseq	0.507	0.445
NO_jason_reseq	-0.585	0.045
B6_jason_reseq	0.671	0.55
MHCII_jason_reseq	0.326	-0.339
Isoniazid02	-1.244	-1.323
Rifampicin4	-0.236	-0.06
Ethambutol3	-0.251	-1.096
Meropenem3	-0.286	-1.051
Vancomycin16	-0.098	-0.692
Rv2680_day32	0.781	0.141
H37Rv_KO_MarP	0.466	0.514
hypoxia_3wks	-0.359	-0.574
hypoxia_6wks	0.81	-0.365
glycerol	0.658	-0.696
cholesterol	-0.073	-0.09
AJ	0.156	-0.166
Bibs02	0.233	0.195
Bibs02c	-0.106	0.062
BL6	0.449	0.686
BL6a	0.296	0.125
BXD01	0.512	0.082
BXD010	0.292	-0.529
BXD011	0.698	-0.221
BXD03	0.23	-0.22
BXD04	0.41	-0.171
BXD05	0.435	-0.283
BXD06	0.671	-0.205
BXD07	1.091	-0.024
BXD08	0.25	-0.272
BXD09	0.63	-0.451
CAST	0.432	-0.153
CCcont	-0.089	-0.229
DS01	-0.299	-0.051
DS02	-0.369	0.29
DS04	0.008	0.153
DS0c	-0.325	-0.126
GP01	0.624	-0.795
GP02	-0.064	-0.952
GP0c	-0.424	-0.942
NOD	-0.223	0.465
NZO	-0.572	0.051
PWK	0.435	0.661
H37Rv_KO_CtpC	-0.315	-1.017
H37Rv_KO_CtpD	-0.427	-0.548
H37Rv_KO_Rv1272	0.481	0.965
H37Rv_KO_SugABC	0.172	0.709
H37Rv_KO_MbtN	0.239	-0.018
Trans05	0.506	0.512
macrophage_unactivated	-0.139	0.167
IL1	0.715	-0.021
Rapamycin	0.519	-0.083
Tcell	0.525	-0.179
GMCSF	0.201	0.259
IFNab	0.145	-0.541
IFNg	0.612	0.227
IFNg_GMCSF1	0.518	0.308
Rv1432_day32	0.837	-0.113
Rv1565c_day32	0.25	0.417
secA2_input	0.676	0.473
delta_Rv3594	-1.256	-0.413
delta_Rv3717	-0.531	-0.613
delta_Rv3811	-0.198	-0.706
delta_Rv0954	-0.57	-0.178
PonA1	0.344	-0.105
EccD1_KO	0.536	0.408
EspI_KO	0.465	0.431
PE35_KO	0.475	0.84
PPE68_KO	0.093	0.595
glycerol2	0.395	-0.439
lignocerate	0.583	-0.028
oleate	1.365	-0.197
phosphatidylcholine	0.59	-0.399
acetate	-0.559	-0.618
glucAc	-0.308	-0.504
Rv0950ko	0.718	0.202
Rv1096ko	1.004	1.782
Rv3684ko	0.282	1.179
delta_otsA_trehalose	0.676	0.202