TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2970c/lipN:

update plot	correlation	link to info on gene
Rv0413/mutT3	(cc=0.4756)	info on Rv0413/mutT3
Rv1624c/-	(cc=0.4444)	info on Rv1624c/-
Rv0804/-	(cc=0.4391)	info on Rv0804/-
Rv0925c/-	(cc=0.4232)	info on Rv0925c/-
Rv3237c/-	(cc=0.4087)	info on Rv3237c/-
Rv3406/-	(cc=0.4014)	info on Rv3406/-
Rv2675c/-	(cc=0.3931)	info on Rv2675c/-
Rv3329/-	(cc=0.3869)	info on Rv3329/-
Rv2061c/-	(cc=0.3855)	info on Rv2061c/-
Rv0131c/fadE1	(cc=0.3782)	info on Rv0131c/fadE1

Correlation of Rv2970c/lipN with Rv1624c/-

Normalized LFCs for Rv2970c/lipN:
(description and provenance of datasets)

	Rv2970c/lipN	Rv1624c/-
Fe_supp_jason_reseq	0.0	-1.34
low_pH_jason_reseq	0.507	-0.346
NO_jason_reseq	-0.585	-2.969
B6_jason_reseq	0.671	0.739
MHCII_jason_reseq	0.326	0.8
Isoniazid02	-1.244	-3.086
Rifampicin4	-0.236	0.617
Ethambutol3	-0.251	-2.706
Meropenem3	-0.286	-2.126
Vancomycin16	-0.098	-0.597
Rv2680_day32	0.781	1.524
H37Rv_KO_MarP	0.466	0.38
hypoxia_3wks	-0.359	-0.096
hypoxia_6wks	0.81	-2.76
glycerol	0.658	-0.111
cholesterol	-0.073	0.217
AJ	0.156	-0.721
Bibs02	0.233	-0.758
Bibs02c	-0.106	0.259
BL6	0.449	0.476
BL6a	0.296	-0.02
BXD01	0.512	0.038
BXD010	0.292	-1.535
BXD011	0.698	-0.555
BXD03	0.23	-2.204
BXD04	0.41	-0.081
BXD05	0.435	-0.283
BXD06	0.671	-0.592
BXD07	1.091	-0.534
BXD08	0.25	-0.476
BXD09	0.63	-0.71
CAST	0.432	0.325
CCcont	-0.089	-0.35
DS01	-0.299	-2.69
DS02	-0.369	-4.318
DS04	0.008	-0.178
DS0c	-0.325	-0.806
GP01	0.624	0.77
GP02	-0.064	0.821
GP0c	-0.424	-0.013
NOD	-0.223	-1.32
NZO	-0.572	-1.104
PWK	0.435	-0.635
H37Rv_KO_CtpC	-0.315	-0.913
H37Rv_KO_CtpD	-0.427	-1.662
H37Rv_KO_Rv1272	0.481	0.75
H37Rv_KO_SugABC	0.172	-0.41
H37Rv_KO_MbtN	0.239	-1.235
Trans05	0.506	0.781
macrophage_unactivated	-0.139	0.562
IL1	0.715	0.747
Rapamycin	0.519	-0.365
Tcell	0.525	-0.453
GMCSF	0.201	0.359
IFNab	0.145	0.197
IFNg	0.612	0.15
IFNg_GMCSF1	0.518	1.288
Rv1432_day32	0.837	0.688
Rv1565c_day32	0.25	-0.073
secA2_input	0.676	-0.357
delta_Rv3594	-1.256	-1.245
delta_Rv3717	-0.531	-0.736
delta_Rv3811	-0.198	-1.805
delta_Rv0954	-0.57	-0.898
PonA1	0.344	-1.874
EccD1_KO	0.536	1.036
EspI_KO	0.465	1.235
PE35_KO	0.475	0.604
PPE68_KO	0.093	1.465
glycerol2	0.395	0.454
lignocerate	0.583	0.298
oleate	1.365	1.344
phosphatidylcholine	0.59	0.611
acetate	-0.559	0.381
glucAc	-0.308	0.056
Rv0950ko	0.718	-0.893
Rv1096ko	1.004	-1.065
Rv3684ko	0.282	-1.156
delta_otsA_trehalose	0.676	-0.609