TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2424c/-:

update plot	correlation	link to info on gene
Rv1367c/-	(cc=0.5961)	info on Rv1367c/-
Rv3055/-	(cc=0.5948)	info on Rv3055/-
Rv2786c/ribF	(cc=0.5633)	info on Rv2786c/ribF
Rv2177c/-	(cc=0.5495)	info on Rv2177c/-
Rv1250/-	(cc=0.5155)	info on Rv1250/-
Rv2980/-	(cc=0.5125)	info on Rv2980/-
Rv0520/-	(cc=0.5123)	info on Rv0520/-
Rv2915c/-	(cc=0.5113)	info on Rv2915c/-
Rv0895/-	(cc=0.5109)	info on Rv0895/-
Rv1735c/-	(cc=0.5061)	info on Rv1735c/-

Correlation of Rv2424c/- with Rv2915c/-

Normalized LFCs for Rv2424c/-:
(description and provenance of datasets)

	Rv2424c/-	Rv2915c/-
Fe_supp_jason_reseq	-0.701	0.384
low_pH_jason_reseq	-1.082	-0.564
NO_jason_reseq	0.349	0.612
B6_jason_reseq	0.996	0.963
MHCII_jason_reseq	-0.668	1.18
Isoniazid02	-0.18	-0.583
Rifampicin4	0.875	0.447
Ethambutol3	0.573	-0.488
Meropenem3	0.659	0.519
Vancomycin16	0.645	-0.255
Rv2680_day32	0.043	-0.528
H37Rv_KO_MarP	0.676	0.073
hypoxia_3wks	-0.167	0.742
hypoxia_6wks	0.121	0.651
glycerol	-1.287	0.138
cholesterol	-0.457	0.216
AJ	0.913	0.709
Bibs02	-0.148	-0.307
Bibs02c	0.196	0.365
BL6	0.455	-0.887
BL6a	-0.29	0.059
BXD01	-0.276	-0.79
BXD010	-0.559	-0.556
BXD011	-0.513	0.133
BXD03	-0.213	0.092
BXD04	0.063	-0.386
BXD05	-0.628	-0.014
BXD06	-0.469	-0.305
BXD07	-0.288	-0.828
BXD08	-0.209	-0.185
BXD09	-0.242	-0.375
CAST	0.295	0.24
CCcont	-1.203	-0.636
DS01	0.33	0.52
DS02	0.775	0.581
DS04	0.864	0.356
DS0c	0.412	0.63
GP01	0.121	-1.518
GP02	0.333	-0.406
GP0c	0.623	-1.971
NOD	0.413	0.099
NZO	0.909	0.144
PWK	0.645	-0.05
H37Rv_KO_CtpC	-0.184	-0.644
H37Rv_KO_CtpD	-0.777	-1.357
H37Rv_KO_Rv1272	-0.222	-0.287
H37Rv_KO_SugABC	-0.344	-0.264
H37Rv_KO_MbtN	-1.569	-1.728
Trans05	1.084	-0.481
macrophage_unactivated	-0.407	-0.578
IL1	-1.1	0.101
Rapamycin	-0.93	-0.681
Tcell	-0.479	-1.049
GMCSF	0.098	-0.483
IFNab	-0.937	-0.846
IFNg	-0.69	-0.326
IFNg_GMCSF1	0.148	-0.154
Rv1432_day32	-0.03	0.562
Rv1565c_day32	0.215	0.088
secA2_input	0.941	0.42
delta_Rv3594	-0.72	-1.623
delta_Rv3717	-0.865	-0.853
delta_Rv3811	-0.769	-0.355
delta_Rv0954	-1.039	-1.072
PonA1	-0.256	-0.479
EccD1_KO	2.559	0.674
EspI_KO	1.657	1.352
PE35_KO	1.173	1.21
PPE68_KO	1.654	1.03
glycerol2	0.184	-0.151
lignocerate	0.183	-0.574
oleate	0.604	0.349
phosphatidylcholine	0.794	-0.021
acetate	0.357	-0.331
glucAc	-0.149	-1.08
Rv0950ko	-0.069	-0.905
Rv1096ko	-0.187	-0.624
Rv3684ko	-0.334	-0.396
delta_otsA_trehalose	-0.098	-0.235