TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2424c/-:

update plot	correlation	link to info on gene
Rv1367c/-	(cc=0.5961)	info on Rv1367c/-
Rv3055/-	(cc=0.5948)	info on Rv3055/-
Rv2786c/ribF	(cc=0.5633)	info on Rv2786c/ribF
Rv2177c/-	(cc=0.5495)	info on Rv2177c/-
Rv1250/-	(cc=0.5155)	info on Rv1250/-
Rv2980/-	(cc=0.5125)	info on Rv2980/-
Rv0520/-	(cc=0.5123)	info on Rv0520/-
Rv2915c/-	(cc=0.5113)	info on Rv2915c/-
Rv0895/-	(cc=0.5109)	info on Rv0895/-
Rv1735c/-	(cc=0.5061)	info on Rv1735c/-

Correlation of Rv2424c/- with Rv1367c/-

Normalized LFCs for Rv2424c/-:
(description and provenance of datasets)

	Rv2424c/-	Rv1367c/-
Fe_supp_jason_reseq	-0.701	-0.668
low_pH_jason_reseq	-1.082	-0.621
NO_jason_reseq	0.349	0.102
B6_jason_reseq	0.996	0.32
MHCII_jason_reseq	-0.668	0.499
Isoniazid02	-0.18	0.322
Rifampicin4	0.875	0.574
Ethambutol3	0.573	1.446
Meropenem3	0.659	0.0
Vancomycin16	0.645	0.265
Rv2680_day32	0.043	-0.364
H37Rv_KO_MarP	0.676	0.176
hypoxia_3wks	-0.167	0.136
hypoxia_6wks	0.121	-0.438
glycerol	-1.287	-0.073
cholesterol	-0.457	-0.132
AJ	0.913	-0.314
Bibs02	-0.148	-0.845
Bibs02c	0.196	-0.4
BL6	0.455	-1.556
BL6a	-0.29	-0.476
BXD01	-0.276	-0.868
BXD010	-0.559	-0.751
BXD011	-0.513	-0.447
BXD03	-0.213	-1.169
BXD04	0.063	-0.891
BXD05	-0.628	-0.533
BXD06	-0.469	-0.746
BXD07	-0.288	-0.944
BXD08	-0.209	-0.416
BXD09	-0.242	-1.607
CAST	0.295	-0.624
CCcont	-1.203	-1.029
DS01	0.33	-0.156
DS02	0.775	-0.044
DS04	0.864	-0.094
DS0c	0.412	0.035
GP01	0.121	-0.481
GP02	0.333	0.1
GP0c	0.623	-0.119
NOD	0.413	0.026
NZO	0.909	0.329
PWK	0.645	-0.655
H37Rv_KO_CtpC	-0.184	0.075
H37Rv_KO_CtpD	-0.777	-0.046
H37Rv_KO_Rv1272	-0.222	-0.075
H37Rv_KO_SugABC	-0.344	-0.189
H37Rv_KO_MbtN	-1.569	-1.426
Trans05	1.084	0.417
macrophage_unactivated	-0.407	-0.789
IL1	-1.1	-0.875
Rapamycin	-0.93	-1.154
Tcell	-0.479	-1.225
GMCSF	0.098	-0.929
IFNab	-0.937	-1.433
IFNg	-0.69	-1.443
IFNg_GMCSF1	0.148	-0.619
Rv1432_day32	-0.03	-0.593
Rv1565c_day32	0.215	0.485
secA2_input	0.941	0.842
delta_Rv3594	-0.72	-1.069
delta_Rv3717	-0.865	-0.668
delta_Rv3811	-0.769	-0.625
delta_Rv0954	-1.039	-0.756
PonA1	-0.256	-1.04
EccD1_KO	2.559	0.599
EspI_KO	1.657	0.345
PE35_KO	1.173	0.554
PPE68_KO	1.654	0.211
glycerol2	0.184	0.448
lignocerate	0.183	-0.057
oleate	0.604	0.595
phosphatidylcholine	0.794	0.682
acetate	0.357	-0.344
glucAc	-0.149	0.346
Rv0950ko	-0.069	-0.081
Rv1096ko	-0.187	0.106
Rv3684ko	-0.334	0.085
delta_otsA_trehalose	-0.098	-0.511