TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv2034/-:

update plot	correlation	link to info on gene
Rv0628c/-	(cc=0.4255)	info on Rv0628c/-
Rv1457c/-	(cc=0.4236)	info on Rv1457c/-
Rv2965c/kdtB	(cc=0.4164)	info on Rv2965c/kdtB
Rv3456c/rplQ	(cc=0.4074)	info on Rv3456c/rplQ
Rv0651/rplJ	(cc=0.4066)	info on Rv0651/rplJ
Rv0812/-	(cc=0.3873)	info on Rv0812/-
Rv2609c/-	(cc=0.3773)	info on Rv2609c/-
Rv0681/-	(cc=0.3751)	info on Rv0681/-
Rv1636/TB15.3	(cc=0.371)	info on Rv1636/TB15.3
Rv0791c/-	(cc=0.3666)	info on Rv0791c/-

Correlation of Rv2034/- with Rv1636/TB15.3

Normalized LFCs for Rv2034/-:
(description and provenance of datasets)

	Rv2034/-	Rv1636/TB15.3
Fe_supp_jason_reseq	0.38	0.0
low_pH_jason_reseq	-0.925	0.0
NO_jason_reseq	1.536	0.0
B6_jason_reseq	-0.723	0.0
MHCII_jason_reseq	-1.112	0.0
Isoniazid02	0.311	0.0
Rifampicin4	1.424	0.0
Ethambutol3	-0.146	0.0
Meropenem3	0.426	0.0
Vancomycin16	0.0	0.0
Rv2680_day32	0.0	0.0
H37Rv_KO_MarP	3.236	0.0
hypoxia_3wks	-0.195	0.0
hypoxia_6wks	-0.933	0.0
glycerol	-0.976	0.0
cholesterol	-1.504	0.0
AJ	-1.593	0.0
Bibs02	0.751	0.0
Bibs02c	-2.172	0.0
BL6	0.725	0.0
BL6a	0.0	0.198
BXD01	-0.8	0.13
BXD010	-1.329	0.128
BXD011	-0.272	0.35
BXD03	1.5	0.0
BXD04	-0.048	0.124
BXD05	1.87	0.0
BXD06	0.05	0.133
BXD07	-1.174	0.851
BXD08	0.236	0.133
BXD09	0.422	0.0
CAST	0.0	0.0
CCcont	1.193	0.0
DS01	1.571	0.0
DS02	0.893	0.0
DS04	2.753	0.0
DS0c	-0.174	0.0
GP01	-1.025	0.0
GP02	-0.864	0.0
GP0c	-1.35	0.0
NOD	0.399	0.0
NZO	-1.691	0.548
PWK	-0.948	0.0
H37Rv_KO_CtpC	0.625	0.0
H37Rv_KO_CtpD	0.452	0.0
H37Rv_KO_Rv1272	-1.464	0.0
H37Rv_KO_SugABC	-0.756	0.0
H37Rv_KO_MbtN	-0.967	0.0
Trans05	1.282	0.0
macrophage_unactivated	-1.398	0.0
IL1	1.13	0.0
Rapamycin	2.296	0.0
Tcell	0.661	0.0
GMCSF	0.776	0.0
IFNab	2.5	0.0
IFNg	0.604	0.0
IFNg_GMCSF1	-1.163	0.0
Rv1432_day32	0.0	0.0
Rv1565c_day32	0.0	0.0
secA2_input	5.28	6.0
delta_Rv3594	2.885	0.0
delta_Rv3717	2.146	0.0
delta_Rv3811	1.392	0.0
delta_Rv0954	-0.357	0.0
PonA1	-0.233	0.0
EccD1_KO	2.773	0.0
EspI_KO	0.0	0.0
PE35_KO	-2.234	0.0
PPE68_KO	-0.426	0.0
glycerol2	0.0	0.0
lignocerate	1.128	0.0
oleate	0.0	0.0
phosphatidylcholine	0.193	0.0
acetate	1.998	0.0
glucAc	1.638	0.0
Rv0950ko	1.276	0.0
Rv1096ko	1.342	0.0
Rv3684ko	-1.261	0.0
delta_otsA_trehalose	0.0	0.0