TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1977/-:

update plot	correlation	link to info on gene
Rv2961/-	(cc=0.4584)	info on Rv2961/-
Rv2329c/narK1	(cc=0.4524)	info on Rv2329c/narK1
Rv2327/-	(cc=0.4454)	info on Rv2327/-
Rv3135/PPE50	(cc=0.4136)	info on Rv3135/PPE50
Rv1030/kdpB	(cc=0.4133)	info on Rv1030/kdpB
Rv2627c/-	(cc=0.3919)	info on Rv2627c/-
Rv2018/-	(cc=0.3851)	info on Rv2018/-
Rv1132/-	(cc=0.3846)	info on Rv1132/-
Rv1185c/fadD21	(cc=0.3805)	info on Rv1185c/fadD21
Rv0071/-	(cc=0.3792)	info on Rv0071/-

Correlation of Rv1977/- with Rv1132/-

Normalized LFCs for Rv1977/-:
(description and provenance of datasets)

	Rv1977/-	Rv1132/-
Fe_supp_jason_reseq	0.316	-0.077
low_pH_jason_reseq	0.027	-0.579
NO_jason_reseq	0.281	0.517
B6_jason_reseq	0.913	0.368
MHCII_jason_reseq	1.289	-0.653
Isoniazid02	-0.221	0.185
Rifampicin4	-0.046	0.06
Ethambutol3	0.444	-0.027
Meropenem3	0.232	1.06
Vancomycin16	-0.287	0.393
Rv2680_day32	2.328	1.473
H37Rv_KO_MarP	-0.085	0.868
hypoxia_3wks	-0.152	-0.056
hypoxia_6wks	-0.568	0.219
glycerol	0.477	0.158
cholesterol	0.184	-0.998
AJ	-0.018	0.35
Bibs02	0.564	-0.265
Bibs02c	-0.061	0.634
BL6	0.108	-0.422
BL6a	-0.564	0.755
BXD01	-0.316	-0.229
BXD010	-0.075	0.37
BXD011	0.11	0.428
BXD03	-0.4	-0.012
BXD04	-0.521	0.314
BXD05	-0.535	-0.181
BXD06	-0.096	0.431
BXD07	-0.372	0.545
BXD08	-0.497	0.2
BXD09	-0.21	-0.189
CAST	0.199	0.292
CCcont	-0.141	-0.041
DS01	-0.058	-0.176
DS02	0.137	-0.707
DS04	0.308	0.246
DS0c	0.596	0.31
GP01	-0.723	0.442
GP02	-0.237	-0.559
GP0c	-0.525	-0.648
NOD	0.53	0.267
NZO	0.231	-0.092
PWK	-0.406	0.053
H37Rv_KO_CtpC	0.14	-0.153
H37Rv_KO_CtpD	0.674	0.409
H37Rv_KO_Rv1272	0.127	0.234
H37Rv_KO_SugABC	-0.43	0.704
H37Rv_KO_MbtN	0.108	-0.658
Trans05	-0.559	-0.67
macrophage_unactivated	0.398	-0.789
IL1	1.528	0.875
Rapamycin	0.813	0.565
Tcell	0.642	-0.218
GMCSF	0.114	-0.209
IFNab	0.538	-0.345
IFNg	0.82	0.668
IFNg_GMCSF1	0.814	-0.471
Rv1432_day32	2.198	2.059
Rv1565c_day32	0.218	-0.368
secA2_input	-0.982	-0.867
delta_Rv3594	0.193	1.557
delta_Rv3717	0.604	1.165
delta_Rv3811	0.549	1.405
delta_Rv0954	0.258	1.043
PonA1	0.287	0.908
EccD1_KO	-0.122	0.125
EspI_KO	0.202	0.108
PE35_KO	-0.128	0.0
PPE68_KO	0.022	0.182
glycerol2	0.723	0.039
lignocerate	0.303	0.268
oleate	0.184	-0.299
phosphatidylcholine	0.342	0.258
acetate	0.71	0.446
glucAc	-0.062	0.468
Rv0950ko	-0.648	0.048
Rv1096ko	-0.446	0.048
Rv3684ko	-0.301	-0.223
delta_otsA_trehalose	-0.879	-0.126