TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1847/-:

update plot	correlation	link to info on gene
Rv0844c/narL	(cc=0.4714)	info on Rv0844c/narL
Rv3840/-	(cc=0.4701)	info on Rv3840/-
Rv0072/-	(cc=0.4655)	info on Rv0072/-
Rv0872c/PE_PGRS15	(cc=0.4498)	info on Rv0872c/PE_PGRS15
Rv1892/-	(cc=0.4494)	info on Rv1892/-
Rv1373/-	(cc=0.4476)	info on Rv1373/-
Rv1831/-	(cc=0.4418)	info on Rv1831/-
Rv3487c/lipF	(cc=0.432)	info on Rv3487c/lipF
Rv2579/dhaA	(cc=0.4307)	info on Rv2579/dhaA
Rv1355c/moeY	(cc=0.4214)	info on Rv1355c/moeY

Correlation of Rv1847/- with Rv3840/-

Normalized LFCs for Rv1847/-:
(description and provenance of datasets)

	Rv1847/-	Rv3840/-
Fe_supp_jason_reseq	0.385	-0.158
low_pH_jason_reseq	-0.621	-1.121
NO_jason_reseq	0.575	0.129
B6_jason_reseq	0.324	-0.108
MHCII_jason_reseq	-0.272	-0.192
Isoniazid02	-0.575	-0.764
Rifampicin4	-0.038	-0.374
Ethambutol3	0.617	-0.652
Meropenem3	-0.918	0.43
Vancomycin16	-0.363	-0.584
Rv2680_day32	0.461	0.162
H37Rv_KO_MarP	0.61	0.182
hypoxia_3wks	-0.223	0.191
hypoxia_6wks	0.035	0.311
glycerol	0.154	-0.032
cholesterol	0.578	0.119
AJ	0.499	0.21
Bibs02	-0.495	0.123
Bibs02c	0.306	-0.69
BL6	-0.095	0.27
BL6a	0.06	-0.059
BXD01	0.223	0.375
BXD010	-0.04	0.567
BXD011	-0.029	0.188
BXD03	0.513	0.728
BXD04	0.263	0.453
BXD05	0.184	0.83
BXD06	0.256	0.55
BXD07	0.628	0.367
BXD08	0.782	0.353
BXD09	0.203	0.68
CAST	0.464	0.402
CCcont	-0.357	-0.058
DS01	0.058	0.05
DS02	-0.589	0.537
DS04	0.538	0.233
DS0c	0.253	0.167
GP01	0.187	0.636
GP02	1.485	1.625
GP0c	-0.213	0.811
NOD	-0.376	0.439
NZO	-0.269	-0.095
PWK	0.573	0.323
H37Rv_KO_CtpC	-0.182	0.238
H37Rv_KO_CtpD	-0.066	0.113
H37Rv_KO_Rv1272	1.354	0.542
H37Rv_KO_SugABC	1.056	0.935
H37Rv_KO_MbtN	1.013	0.526
Trans05	0.859	-0.102
macrophage_unactivated	0.275	-0.076
IL1	0.258	-0.208
Rapamycin	0.242	0.47
Tcell	0.502	0.166
GMCSF	0.349	0.111
IFNab	0.704	0.49
IFNg	0.604	0.2
IFNg_GMCSF1	0.474	0.101
Rv1432_day32	0.249	0.349
Rv1565c_day32	0.355	0.039
secA2_input	-0.199	0.377
delta_Rv3594	-0.229	-0.415
delta_Rv3717	-0.103	0.074
delta_Rv3811	-0.25	-0.164
delta_Rv0954	-0.353	-0.225
PonA1	-0.63	-0.421
EccD1_KO	-0.253	-0.431
EspI_KO	-0.431	-0.191
PE35_KO	0.009	-0.537
PPE68_KO	0.355	-0.576
glycerol2	0.504	0.314
lignocerate	0.785	-0.073
oleate	0.649	0.625
phosphatidylcholine	0.651	0.108
acetate	0.037	-0.487
glucAc	0.059	-0.564
Rv0950ko	0.302	0.697
Rv1096ko	0.808	0.0
Rv3684ko	0.275	0.049
delta_otsA_trehalose	-1.233	-1.073