TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1847/-:

update plot	correlation	link to info on gene
Rv0844c/narL	(cc=0.4714)	info on Rv0844c/narL
Rv3840/-	(cc=0.4701)	info on Rv3840/-
Rv0072/-	(cc=0.4655)	info on Rv0072/-
Rv0872c/PE_PGRS15	(cc=0.4498)	info on Rv0872c/PE_PGRS15
Rv1892/-	(cc=0.4494)	info on Rv1892/-
Rv1373/-	(cc=0.4476)	info on Rv1373/-
Rv1831/-	(cc=0.4418)	info on Rv1831/-
Rv3487c/lipF	(cc=0.432)	info on Rv3487c/lipF
Rv2579/dhaA	(cc=0.4307)	info on Rv2579/dhaA
Rv1355c/moeY	(cc=0.4214)	info on Rv1355c/moeY

Correlation of Rv1847/- with Rv1355c/moeY

Normalized LFCs for Rv1847/-:
(description and provenance of datasets)

	Rv1847/-	Rv1355c/moeY
Fe_supp_jason_reseq	0.385	-0.611
low_pH_jason_reseq	-0.621	0.586
NO_jason_reseq	0.575	-0.735
B6_jason_reseq	0.324	0.15
MHCII_jason_reseq	-0.272	0.525
Isoniazid02	-0.575	0.0
Rifampicin4	-0.038	-0.114
Ethambutol3	0.617	0.32
Meropenem3	-0.918	0.187
Vancomycin16	-0.363	0.414
Rv2680_day32	0.461	0.0
H37Rv_KO_MarP	0.61	-0.054
hypoxia_3wks	-0.223	0.626
hypoxia_6wks	0.035	-0.48
glycerol	0.154	-0.554
cholesterol	0.578	1.134
AJ	0.499	0.222
Bibs02	-0.495	0.175
Bibs02c	0.306	-0.268
BL6	-0.095	0.143
BL6a	0.06	-0.082
BXD01	0.223	0.443
BXD010	-0.04	0.889
BXD011	-0.029	0.146
BXD03	0.513	0.499
BXD04	0.263	-0.276
BXD05	0.184	0.177
BXD06	0.256	0.176
BXD07	0.628	0.301
BXD08	0.782	-0.055
BXD09	0.203	0.373
CAST	0.464	-0.953
CCcont	-0.357	-0.158
DS01	0.058	-0.469
DS02	-0.589	-0.135
DS04	0.538	-0.249
DS0c	0.253	0.207
GP01	0.187	-0.196
GP02	1.485	0.705
GP0c	-0.213	0.345
NOD	-0.376	-0.737
NZO	-0.269	-0.04
PWK	0.573	0.857
H37Rv_KO_CtpC	-0.182	-0.578
H37Rv_KO_CtpD	-0.066	-0.106
H37Rv_KO_Rv1272	1.354	0.028
H37Rv_KO_SugABC	1.056	1.047
H37Rv_KO_MbtN	1.013	0.726
Trans05	0.859	-0.706
macrophage_unactivated	0.275	-0.398
IL1	0.258	-0.181
Rapamycin	0.242	-0.092
Tcell	0.502	0.098
GMCSF	0.349	-0.079
IFNab	0.704	-0.281
IFNg	0.604	-0.425
IFNg_GMCSF1	0.474	-0.396
Rv1432_day32	0.249	0.329
Rv1565c_day32	0.355	-0.188
secA2_input	-0.199	-0.667
delta_Rv3594	-0.229	-1.563
delta_Rv3717	-0.103	-1.232
delta_Rv3811	-0.25	-0.761
delta_Rv0954	-0.353	-1.627
PonA1	-0.63	-1.577
EccD1_KO	-0.253	-1.273
EspI_KO	-0.431	-0.799
PE35_KO	0.009	-0.169
PPE68_KO	0.355	-0.186
glycerol2	0.504	0.297
lignocerate	0.785	0.068
oleate	0.649	0.829
phosphatidylcholine	0.651	0.514
acetate	0.037	-0.489
glucAc	0.059	-0.51
Rv0950ko	0.302	0.476
Rv1096ko	0.808	0.549
Rv3684ko	0.275	0.177
delta_otsA_trehalose	-1.233	-1.986