TnSeqCorr

• These are correlations of TnSeq responses across 82 experimental conditions.
• LFCs (log2-fold-changes) were computed for each gene in each condition relative to a relevant control condition (e.g. H37Rv grown on 7H9).
• The LFCs were normalized by dividing by the standard deviation for each condition. (so roughly, |LFC|>2 are the outliers, i.e. tails of the distribution)
• Note that essential genes often have LFCs around 0.
• Data for some genes is not available if they have less than 3 TA sites, or the dynamic range of LFCs is less than 2.0 across all conditions. (This is the case for many essential genes.)
• 'leverage' on each plot is a statistical score that indicates how much the regression is influenced by a few outlier points; the traditional threshold is indicated on the plots (3p/n, which is about 0.07 for this dataset), but in practice, cases with leverage > ~0.2 seem to be the least reliable (most misleading) correlation coefficients.

Top 10 genes with highest correlation to Rv1847/-:

update plot	correlation	link to info on gene
Rv0844c/narL	(cc=0.4714)	info on Rv0844c/narL
Rv3840/-	(cc=0.4701)	info on Rv3840/-
Rv0072/-	(cc=0.4655)	info on Rv0072/-
Rv0872c/PE_PGRS15	(cc=0.4498)	info on Rv0872c/PE_PGRS15
Rv1892/-	(cc=0.4494)	info on Rv1892/-
Rv1373/-	(cc=0.4476)	info on Rv1373/-
Rv1831/-	(cc=0.4418)	info on Rv1831/-
Rv3487c/lipF	(cc=0.432)	info on Rv3487c/lipF
Rv2579/dhaA	(cc=0.4307)	info on Rv2579/dhaA
Rv1355c/moeY	(cc=0.4214)	info on Rv1355c/moeY

Correlation of Rv1847/- with Rv0844c/narL

Normalized LFCs for Rv1847/-:
(description and provenance of datasets)

	Rv1847/-	Rv0844c/narL
Fe_supp_jason_reseq	0.385	-0.821
low_pH_jason_reseq	-0.621	-0.885
NO_jason_reseq	0.575	-0.798
B6_jason_reseq	0.324	-1.434
MHCII_jason_reseq	-0.272	-1.717
Isoniazid02	-0.575	-0.1
Rifampicin4	-0.038	0.208
Ethambutol3	0.617	1.001
Meropenem3	-0.918	0.189
Vancomycin16	-0.363	-0.342
Rv2680_day32	0.461	0.584
H37Rv_KO_MarP	0.61	0.126
hypoxia_3wks	-0.223	-0.167
hypoxia_6wks	0.035	-0.334
glycerol	0.154	1.508
cholesterol	0.578	0.542
AJ	0.499	0.509
Bibs02	-0.495	-0.719
Bibs02c	0.306	-0.943
BL6	-0.095	1.836
BL6a	0.06	1.204
BXD01	0.223	0.829
BXD010	-0.04	0.842
BXD011	-0.029	1.187
BXD03	0.513	1.108
BXD04	0.263	1.469
BXD05	0.184	0.771
BXD06	0.256	0.426
BXD07	0.628	0.737
BXD08	0.782	1.32
BXD09	0.203	1.096
CAST	0.464	0.282
CCcont	-0.357	1.334
DS01	0.058	0.224
DS02	-0.589	-0.191
DS04	0.538	-0.17
DS0c	0.253	-0.358
GP01	0.187	1.085
GP02	1.485	2.145
GP0c	-0.213	1.153
NOD	-0.376	-0.884
NZO	-0.269	0.337
PWK	0.573	-0.254
H37Rv_KO_CtpC	-0.182	1.893
H37Rv_KO_CtpD	-0.066	1.565
H37Rv_KO_Rv1272	1.354	2.107
H37Rv_KO_SugABC	1.056	1.083
H37Rv_KO_MbtN	1.013	1.304
Trans05	0.859	1.91
macrophage_unactivated	0.275	0.707
IL1	0.258	0.507
Rapamycin	0.242	0.319
Tcell	0.502	0.417
GMCSF	0.349	1.127
IFNab	0.704	0.753
IFNg	0.604	0.214
IFNg_GMCSF1	0.474	0.277
Rv1432_day32	0.249	0.675
Rv1565c_day32	0.355	0.215
secA2_input	-0.199	-0.549
delta_Rv3594	-0.229	-0.912
delta_Rv3717	-0.103	-0.745
delta_Rv3811	-0.25	-1.019
delta_Rv0954	-0.353	-0.574
PonA1	-0.63	-0.895
EccD1_KO	-0.253	-0.03
EspI_KO	-0.431	0.876
PE35_KO	0.009	0.528
PPE68_KO	0.355	0.627
glycerol2	0.504	0.659
lignocerate	0.785	0.951
oleate	0.649	1.168
phosphatidylcholine	0.651	0.808
acetate	0.037	-0.136
glucAc	0.059	0.086
Rv0950ko	0.302	-0.075
Rv1096ko	0.808	0.169
Rv3684ko	0.275	-0.429
delta_otsA_trehalose	-1.233	-1.055